No primeiro momento vamos definir alguns termos farmacol\u00f3gicos que nos ajudar\u00e3o ao longo do texto a compreender muito melhor os conceitos complexos que nos ajudar\u00e3o a escolher a dose ideal.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Produtos” _builder_version=”4.7.7″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_module=”16824″][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default” background_enable_color=”off”][et_pb_shop type=”best_selling” posts_number=”8″ show_pagination=”on” module_class=”custom-shop” _builder_version=”4.8.1″ _module_preset=”default” title_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false”][\/et_pb_shop][et_pb_signup mailchimp_list=”higeacbd|5b4d14cf0e” first_name_field=”off” last_name_field=”off” title=”Inscreva-se e receba um desconto de 10%” _builder_version=”4.8.1″ header_level=”h4″ header_font=”|800|||||||” header_text_align=”center” header_text_color=”#000000″ header_font_size=”35px” header_line_height=”1.2em” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” button_custom_padding=”18px|0px|18px|0px|true|true” button_custom_padding_tablet=”14px||14px||true|true” button_custom_padding_phone=”12px||12px||true|true” button_custom_padding_last_edited=”on|phone” background_layout=”light” header_font_size_tablet=”25px” header_font_size_phone=”20px” header_font_size_last_edited=”on|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style_button=”preset4″ box_shadow_horizontal_button=”0px” box_shadow_vertical_button=”2px” box_shadow_color_button=”#00a88d” button_text_color__hover=”#28221d” button_text_color__hover_enabled=”on|hover” box_shadow_color_button__hover=”#000000″ box_shadow_color_button__hover_enabled=”on|desktop”][\/et_pb_signup][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” background_color=”#f3f3f1″ custom_padding=”14px||27px|||”][et_pb_row _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”12px||13px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.6.6″ _module_preset=”default” header_2_font=”|800|||||||” header_2_text_align=”center” header_2_font_size=”35px” header_2_line_height=”1.2em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||-5px|||” custom_padding=”||0px|||”]<\/p>\n
Farmacocin\u00e9tica<\/h2>\n
A sua etimologia j\u00e1 nos d\u00e1 uma pista do que este ramo da ci\u00eancia pode tratar. Por um lado, “Farmaco” diz-nos que est\u00e1 relacionado com a Farmacologia<\/a> e a “Cin\u00e9tica” podemos inferir que tem a ver com algo que est\u00e1 em movimento. Na verdade, a Farmacocin\u00e9tica estuda como as drogas se movem atrav\u00e9s do nosso corpo, desde a entrada at\u00e9 \u00e0 sa\u00edda do nosso corpo.<\/p>\n Refere-se a onde uma subst\u00e2ncia entra no nosso organismo. Pode ser intravenoso, oral, t\u00f3pico, retal, etc…<\/p>\n \u00c9 o organismo-alvo em que os f\u00e1rmacos funcionam. S\u00e3o geralmente prote\u00ednas, l\u00edpidos e \u00e1cidos nucleicos.<\/p>\n Na Farmacocin\u00e9tica, a absor\u00e7\u00e3o do processo de penetra\u00e7\u00e3o do f\u00e1rmaco por membranas celulares para chegar ao sangue \u00e9 chamada de absor\u00e7\u00e3o. A administra\u00e7\u00e3o intravenosa ignora diretamente o processo de absor\u00e7\u00e3o.<\/p>\n Refere-se \u00e0 forma como a droga viaja atrav\u00e9s do sangue para os diferentes tecidos do corpo.<\/p>\n O nosso corpo transforma drogas em sub-produtos para facilitar a sua elimina\u00e7\u00e3o. Um f\u00e1rmaco que \u00e9 fornecido oralmente passar\u00e1 sempre pelo filtro metab\u00f3lico que o quebrar\u00e1 em sub-produtos e n\u00e3o passar\u00e1 para a corrente sangu\u00ednea a 100%<\/p>\n \u00c9 o processo pelo qual o nosso corpo acaba por remover as drogas.<\/p>\n \u00c9 a quantidade de droga que passa para a corrente sangu\u00ednea e est\u00e1 dispon\u00edvel para o nosso corpo.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-cbd.jpg” alt=”cbd de biodisponibilidade” title_text=”cbd de biodisponibilidade” force_fullwidth=”on” _builder_version=”4.5.8″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”Ent\u00e3o, o que \u00e9 biodisponibilidade?” button_url=”#top” _builder_version=”4.5.8″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n Na Farmacocin\u00e9tica, a Biodisponibilidade de um f\u00e1rmaco<\/strong> faz parte do estudo da absor\u00e7\u00e3o e \u00e9 a percentagem e taxa a que o composto atinge o plasma na nossa circula\u00e7\u00e3o sist\u00e9mica. Portanto, se um medicamento for entregue intravenosamente (IV), por defini\u00e7\u00e3o, a sua Biodisponibilidade \u00e9 de 100%.<\/strong> O nosso corpo teria ent\u00e3o 100% do composto dispon\u00edvel no sistema circulat\u00f3rio para atingir o objetivo terap\u00eautico.<\/p>\n Por conseguinte, podemos inferir que para calcular a biodisponibilidade de um f\u00e1rmaco<\/strong> \u00e9 essencial diferenciar as vias de administra\u00e7\u00e3o. O quadro seguinte detalha a biodisponibilidade para cada via:<\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” background_color=”#f3f3f1″ custom_padding=”14px||27px|||”][et_pb_row _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”12px||13px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.5.8″ _module_preset=”default” header_2_font=”|800|||||||” header_2_text_align=”center” header_2_font_size=”35px” header_2_line_height=”1.2em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||-5px|||” custom_padding=”||0px|||”]<\/p>\n A forma mais comum e segura de tomar qualquer droga em casa \u00e9 oral. Quando ingerimos um medicamento \u00e9 absorvido pelo f\u00edgado que \u00e9 respons\u00e1vel por pass\u00e1-lo para a corrente sangu\u00ednea. No entanto, nem toda a droga atinge a nossa circula\u00e7\u00e3o sist\u00e9mica, uma vez que o metabolismo do f\u00edgado decomp\u00f5e algumas das subst\u00e2ncias ativas que nunca circular\u00e3o pelo nosso corpo. Por conseguinte, quando queremos calcular a biodisponibilidade de um f\u00e1rmaco administrado oralmente, devemos tamb\u00e9m ter em conta este efeito do metabolismo do primeiro passo hep\u00e1tico.<\/p>\n Alguns compostos (como o CBD que discutiremos mais tarde) t\u00eam um grande efeito de primeira etapa para que administrado oralmente n\u00e3o obtenham concentra\u00e7\u00e3o plasm\u00e1tica suficiente para atingir o objetivo terap\u00eautico. Nestes casos, \u00e9 indicado procurar uma via de administra\u00e7\u00e3o alternativa. A forma mais comum e segura de tomar qualquer droga em casa \u00e9 oral. Quando ingerimos um medicamento \u00e9 absorvido pelo f\u00edgado que \u00e9 respons\u00e1vel por pass\u00e1-lo para a corrente sangu\u00ednea. No entanto, nem toda a droga atinge a nossa circula\u00e7\u00e3o sist\u00e9mica, uma vez que o metabolismo do f\u00edgado decomp\u00f5e algumas das subst\u00e2ncias ativas que nunca circular\u00e3o pelo nosso corpo.<\/p>\n Por conseguinte, quando queremos calcular a biodisponibilidade de um f\u00e1rmaco administrado oralmente, devemos tamb\u00e9m ter em conta este efeito do metabolismo do primeiro passo hep\u00e1tico. Alguns compostos (como o CBD que discutiremos mais tarde) t\u00eam um grande efeito de primeira etapa para que administrado oralmente n\u00e3o obtenham concentra\u00e7\u00e3o plasm\u00e1tica suficiente para atingir o objetivo terap\u00eautico. Nestes casos, \u00e9 indicado procurar uma via de administra\u00e7\u00e3o alternativa.<\/p>\n A administra\u00e7\u00e3o sublingual,<\/a>por exemplo, aumenta a biodisponibilidade do f\u00e1rmaco, uma vez que sob a l\u00edngua temos in\u00fameros capilares e o tecido \u00e9 perme\u00e1vel o suficiente para que a subst\u00e2ncia passe diretamente para a corrente sangu\u00ednea. Alguns exemplos de biodisponibilidade de algumas drogas que conhecemos mais:<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”40px||40px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.4.4″ locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.4.4″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-en-alimentos.jpg” alt=”biodisponibilidade nos alimentos” title_text=”biodisponibilidade nos alimentos” _builder_version=”4.5.8″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.8″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.9.2″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n Estudar a biodisponibilidade dos nutrientes nos alimentos \u00e9 fundamental<\/a> <\/strong> para entender como alimentar toda a popula\u00e7\u00e3o com recursos dispon\u00edveis. \u00c9 por isso que est\u00e3o a ser feitos enormes esfor\u00e7os para compreender a biodisponibilidade dos nutrientes em cada alimento e quais os fatores do indiv\u00edduo que podem influenci\u00e1-lo.<\/p>\n Os macronutrientes (prote\u00ednas, hidratos de carbono e gorduras) conseguem uma biodisponibilidade de at\u00e9 90%. Uma vez que os macronutrientes gozam de uma biodisponibilidade t\u00e3o elevada, o valor biol\u00f3gico \u00e9 dado grande import\u00e2ncia, por exemplo, preferimos gorduras insaturadas ricas em \u00e1cidos \u00f3mega 3, 6 e 9 e prote\u00ednas que cont\u00eam a maior quantidade de amino\u00e1cidos essenciais que o nosso corpo n\u00e3o \u00e9 capaz de sintetizar.<\/p>\n No entanto, o estudo da biodisponibilidade de micronutrientes como vitaminas e minerais \u00e9 muito mais complicado, uma vez que o seu processo digestivo \u00e9 mais complexo e envolve muito mais fatores que alteram a biodisponibilidade destes em cada indiv\u00edduo.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-en-el-cbd.jpg” alt=”biodisponibilidade em cbd” title_text=”biodisponibilidade em cbd” force_fullwidth=”on” _builder_version=”4.5.8″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”Qual \u00e9 a biodisponibilidade do \u00f3leo de CBD? Qual \u00e9 a rota ideal de administra\u00e7\u00e3o?” button_url=”#top” _builder_version=”4.5.8″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n Muitas vezes olhamos para a concentra\u00e7\u00e3o de \u00f3leos<\/a> antes de pararmos para pensar exatamente no quanto precisamos para tratar o nosso problema. \u00c9 por isso que, a seguir, vamos tentar entender como o nosso corpo absorve o CBD. Lembre-se que a rota pela qual a administramos determinar\u00e1 a sua absor\u00e7\u00e3o e biodisponibilidade.<\/p>\n Uma das vias de administra\u00e7\u00e3o mais comuns \u00e9 em c\u00e1psulas comest\u00edveis que passar\u00e3o pelo nosso sistema digestivo e o CBD ser\u00e1 absorvido pelo f\u00edgado. O CBD tem um efeito metabolismo de primeira etapa do f\u00edgado bastante alto, por isso o nosso f\u00edgado ir\u00e1 decomp\u00f4-lo deixando uma biodisponibilidade de 4% – 20% (de acordo com estudos recentes). \u00c9 claro que a ind\u00fastria est\u00e1 a tentar responder a este problema de biodisponibilidade do CBD oralmente e ao investigar emuls\u00f5es sol\u00faveis em \u00e1gua que aumentam a absor\u00e7\u00e3o e a biodisponibilidade em cerca de 50%. Se optarmos por esta via de administra\u00e7\u00e3o, devemos tamb\u00e9m ter em conta se o nosso est\u00f4mago est\u00e1 vazio ou cheio antes de consumir as c\u00e1psulas. O CBD \u00e9 sol\u00favel em gordura que, se o acompanharmos com refei\u00e7\u00f5es ricas em gordura, podemos aumentar a sua biodisponibilidade oral.<\/p>\n <\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.5.1″ custom_margin=”|auto|-2px|auto||” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.5.1″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/farmacodinamia-cannabinoides.jpg” alt=”canabin\u00f3ides farmacodin\u00e2micos” title_text=”canabin\u00f3ides farmacodin\u00e2micos” align=”center” _builder_version=”4.5.8″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.9.0″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n A administra\u00e7\u00e3o sublingual de qualquer f\u00e1rmaco aumentar\u00e1 automaticamente a biodisponibilidade do f\u00e1rmaco, uma vez que as membranas mucosas absorver\u00e3o parte da subst\u00e2ncia ativa diretamente na corrente sangu\u00ednea. Para isso, ter\u00e1 de manter as got\u00edculas de \u00f3leo durante 90 segundos debaixo da l\u00edngua antes de as engolir. Com a administra\u00e7\u00e3o sublingual pode atingir 12% a 35% de biodisponibilidade de CBD.<\/p>\n Ao vaping \u00f3leos de CBD, inalamos o composto que atinge o nosso pulm\u00e3o. Os alv\u00e9olos pulmonares ser\u00e3o respons\u00e1veis pelo transporte da subst\u00e2ncia ativa muito rapidamente para a corrente sangu\u00ednea, de modo a que a absor\u00e7\u00e3o seja quase instant\u00e2nea e uma biodisponibilidade superior a 50% possa ser alcan\u00e7ada.<\/p>\n Existem in\u00fameros cremes e b\u00e1lsamos com CBD como subst\u00e2ncia ativa. A pele \u00e9 uma membrana muito densa e baixa permeabilidade que afeta diretamente a absor\u00e7\u00e3o. \u00c9 por esta raz\u00e3o que, se escolhermos a via t\u00f3pica para usufruir dos benef\u00edcios do CBD, teremos de olhar muito para a concentra\u00e7\u00e3o de Canabidiol desses produtos. Esta \u00e9 a melhor maneira de aliviar as dores localizadas, as camadas densas do produto devem ser aplicadas \u00e0 pele e deix\u00e1-la trabalhar at\u00e9 que a pele termine de absorver. Em todo o caso, a aplica\u00e7\u00e3o de qualquer concentra\u00e7\u00e3o de CBD na pele<\/a> n\u00e3o far\u00e1 com que atinja a corrente sangu\u00ednea, pelo que a sua biodisponibilidade \u00e9 nula. Existem manchas transd\u00e9rmicas de CBD que s\u00e3o absorvidas na corrente sangu\u00ednea, mas a sua biodisponibilidade exata ainda n\u00e3o \u00e9 conhecida.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.5.1″ custom_margin=”|auto|-2px|auto||” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.5.1″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/porque-tenemos-receptores-cannabinoides.jpg” alt=”porque temos recetores canabin\u00f3ides” title_text=”porque temos recetores canabin\u00f3ides” align=”center” _builder_version=”4.5.8″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.8″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”off|desktop”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.9.3″ hover_enabled=”0″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” sticky_enabled=”0″]<\/p>\n At\u00e9 agora, s\u00f3 fal\u00e1mos sobre a biodisponibilidade do canabin\u00f3ide cbd isolado. 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background_color_gradient_end=”rgba(255,255,255,0)” background_color_gradient_end_position=”30%” background_color_gradient_overlays_image=”on” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/aceite-de-cannabis-cbd.jpg” custom_padding=”100px|0px|30vw|0px” animation_style=”slide” animation_direction=”bottom” animation_duration=”1250ms” animation_intensity_slide=”1%” saved_tabs=”all”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ text_font=”|500|||||||” text_text_color=”rgba(47,56,84,0.5)” text_font_size=”16px” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”|700|||||||” header_2_font_size=”50px” header_2_line_height=”1.3em” text_orientation=”center” max_width=”700px” module_alignment=”center”]<\/p>\n Inscreva-se e receba um desconto de 10% na sua compra. <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row 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_dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_text_color=”#000000″ custom_margin=”||0px||false|false” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_text _builder_version=”4.6.5″ _module_preset=”default” text_font_size=”15px”]pedidos@higeacbd.com<\/a>[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/formas-de-pago.png” alt=”op\u00e7\u00f5es de pagamento” title_text=”op\u00e7\u00f5es de pagamento” _builder_version=”4.6.5″ _module_preset=”default” custom_margin=”10px||10px||false|false”][\/et_pb_image][et_pb_text admin_label=”DMCA protected” _builder_version=”4.6.5″ _module_preset=”default” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false”] Rota da Administra\u00e7\u00e3o<\/h2>\n
Diana Terap\u00eautica<\/h2>\n
Absor\u00e7\u00e3o<\/h2>\n
Distribui\u00e7\u00e3o<\/h2>\n
Metabolismo<\/h2>\n
Excre\u00e7\u00e3o<\/h2>\n
Concentra\u00e7\u00e3o de Plasma<\/h2>\n
![\"Biodisponibilidade\"](\"https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad.jpg\")
<\/p>\n![\"curva](\"https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/curva-de-concentracion-plasmatica.jpg\")
<\/p>\n\n
Outros fatores que influenciam a biodisponibilidade de um f\u00e1rmaco incluem:<\/h3>\n
\n
A biodisponibilidade dos nutrientes nos alimentos<\/h2>\n
C\u00e1psulas orais<\/h3>\n
CBD concentra-se sublinguicamente<\/h3>\n
Vaping e-l\u00edquido (inala\u00e7\u00e3o)<\/h3>\n
Uso t\u00f3pico<\/h3>\n
Sinergias que aumentam a biodisponibilidade: Terpenes, Flavonoides e outros Canabin\u00f3ides<\/h2>\n
\n
Quanto tempo leva para o nosso corpo eliminar completamente o CBD?<\/h2>\n
Itens relacionados<\/h4>\n
Subscreva a nossa newsletter<\/h2>\n
Loja<\/h4>\n
Guias<\/h4>\n
Saiba mais<\/h4>\n
Aviso legal e pol\u00edtica de privacidade<\/h4>\n
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<\/a><\/p>\n