{"id":57526,"date":"2021-07-09T13:12:16","date_gmt":"2021-07-09T13:12:16","guid":{"rendered":"https:\/\/higeacbd.com\/?p=57526"},"modified":"2021-12-03T13:32:30","modified_gmt":"2021-12-03T13:32:30","slug":"recetores-vanyloides","status":"publish","type":"post","link":"https:\/\/higeacbd.com\/pt-pt\/datos\/recetores-vanyloides","title":{"rendered":"Recetores vanyl\u00f3ides"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Hero” _builder_version=”4.9.7″ background_color=”rgba(255,255,255,0.65)” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/07\/los-receptores-vaniloides-1.jpg” background_blend=”soft-light” custom_padding=”3vw||1vw|||” global_colors_info=”{}”][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_cta title=”Recetores vanyl\u00f3ides” _builder_version=”4.9.7″ header_level=”h1″ header_font=”|800|||||||” header_font_size=”45px” header_line_height=”1.3em” body_font=”|800|||||||” body_text_color=”#000000″ body_font_size=”20px” body_line_height=”1.6em” use_background_color=”off” custom_button=”on” button_text_size=”14px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_width=”8px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” background_layout=”light” animation_direction=”bottom” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” button_text_color_hover=”#ffffff” button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”rgba(47,56,84,0.9)” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”rgba(47,56,84,0.9)” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Products” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”20px||11px||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.5.1″ custom_padding=”8px||17px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.14.2″ text_font=”|500|||||||” text_text_color=”#000000″ quote_font=”||||||||” header_font=”||||||||” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.4em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||12px|||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Neste artigo falaremos sobre recetores vanyl\u00f3ides,<\/strong>cuja ativa\u00e7\u00e3o pode ter um papel importante numa variedade de fun\u00e7\u00f5es fisiol\u00f3gicas. Estes incluem a liberta\u00e7\u00e3o de mediadores inflamat\u00f3rios no corpo, mobilidade gastrointestinal e regula\u00e7\u00e3o da temperatura.<\/p>\n

Na verdade, o recetor potencial transit\u00f3rio V1, conhecido simplesmente como TRPV1 tem uma fun\u00e7\u00e3o vital nos estados fisiol\u00f3gicos e patol\u00f3gicos do aparelho digestivo.<\/strong> \u00c9 tamb\u00e9m importante para o sistema cardiovascular e respirat\u00f3rio, de acordo com um grande n\u00famero de pesquisas publicadas nos \u00faltimos anos.<\/p>\n

O objetivo deste artigo \u00e9 explicar a fun\u00e7\u00e3o e os efeitos dos receptores vanil\u00f3ides <\/strong>em doen\u00e7as espec\u00edficas, como a s\u00edndrome do intestino irrit\u00e1vel<\/a>, hipertens\u00e3o<\/a> e asma<\/a>.<\/p>\n

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O que s\u00e3o recetores vanyl\u00f3ides?<\/h2>\n

TRPV1\/TRPV2, TRPV3, TRPV4 e TRPV5\/TRPV6 s\u00e3o membros da subfam\u00edia do Recetor Potencial Transit\u00f3rio (TRPV), que est\u00e1 classificada em quatro grupos de acordo com a homologia. Os membros da subfam\u00edia TRPV atuam como complexos tetram\u00e9ricos com seis repeti\u00e7\u00f5es de anquiloso terminal N em cada subunidade.<\/p>\n

Todos estes recetores vanyloid podem desempenhar diferentes fun\u00e7\u00f5es no corpo, gra\u00e7as \u00e0s suas diferen\u00e7as de estrutura e distribui\u00e7\u00e3o.<\/strong> Por exemplo, o recetor TRPV1 funciona como um recetor multissensorial para sinais de danos potenciais, e participa em muitas fun\u00e7\u00f5es essenciais, como a contra\u00e7\u00e3o de c\u00e9lulas musculares.<\/p>\n

Por seu lado, o recetor TRPV3, \u00e9 fundamental para m\u00faltiplas fun\u00e7\u00f5es da pele, incluindo a barreira cut\u00e2nea, e a morfog\u00e9nese capilar.<\/a> Mas comparado com os outros, o recetor TRPV1 \u00e9 o principal canal para a dete\u00e7\u00e3o e integra\u00e7\u00e3o de est\u00edmulos nociceptivos t\u00e9rmicos e qu\u00edmicos em fibras sensoriais do nervo.<\/p>\n

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Os recetores vanyloid t\u00eam uma estrutura tetr\u00f3pica composta por seis regi\u00f5es transmembranas,<\/strong>bem como um grupo hidrof\u00f3bico que se situa entre a quinta e a sexta regi\u00f5es transmembranas.<\/p>\n

Os investigadores analisaram a estrutura do TRPV1 usando microscopia crioeletr\u00f3nica numa resolu\u00e7\u00e3o de 19\u00c5. Durante esta investiga\u00e7\u00e3o, a estrutura global dos recetores vanyloid foi dividida em partes superiores e inferiores, correspondentes \u00e0s regi\u00f5es transmembrana e intracelular do canal.<\/p>\n

Tamb\u00e9m foi descoberto que a estrutura dos recetores vaniloides tem dimens\u00f5es de comprimento, largura e altura, correspondentes a 100 \u00c5 \u00d7 110 \u00c5 \u00d7 110 \u00c5, respectivamente. O estudo revelou ainda a exist\u00eancia de um mecanismo regulador de dois port\u00f5es para estes recetores.<\/p>\n

Neste caso, descobriu-se que as quinta e sexta regi\u00f5es de prote\u00edna transmembrana de cada subunidade TRPV1 combinam para formar uma regi\u00e3o porosa no canal.<\/p>\n

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Caracter\u00edsticas biol\u00f3gicas e distribui\u00e7\u00e3o de TRPV1<\/h2>\n

Nos mam\u00edferos, os recetores vanyloid s\u00e3o amplamente distribu\u00eddos em fibras nervosas sensoriais do tipo C amiel\u00ednicas,<\/strong>e parcialmente, em fibras nervosas sensoriais do tipo A\u03b4 menos mielinizadas.<\/p>\n

No nosso sistema neuronal perif\u00e9rico, estas fibras s\u00e3o encontradas no g\u00e2nglio dorsal, no g\u00e2nglio trigeminal, bem como no g\u00e2nglio vago, e em outros pequenos neur\u00f3nios. Entretanto, no sistema nervoso central, s\u00e3o expressas no t\u00e1lamo, am\u00edgdala, corpo estriatal, e outras regi\u00f5es.<\/p>\n

A import\u00e2ncia dos recetores vanyl\u00f3ides \u00e9 que eles est\u00e3o presentes no p\u00e2ncreas, cora\u00e7\u00e3o, f\u00edgado, pulm\u00f5es e outros \u00f3rg\u00e3os vitais do corpo humano.<\/strong> Por outro lado, no trato intestinal, o recetor transit\u00f3rio V1, \u00e9 distribu\u00eddo principalmente no plexo nervoso submucosal do trato intestinal.<\/p>\n

Tamb\u00e9m \u00e9 encontrado no plexo do nervo mioenterico, na mucosa do m\u00fasculo gastrointestinal, e al\u00e9m disso, em alguns tecidos n\u00e3o nervosos, como o caso das c\u00e9lulas mucosas g\u00e1stricas.<\/p>\n

Gra\u00e7as \u00e0 pesquisa, sabe-se que os recetores de vanil\u00f3ide s\u00e3o amplamente distribu\u00eddos nas fibras nervosas sensoriais respirat\u00f3rias do nosso sistema respirat\u00f3rio. Neste caso, estamos a falar especificamente de fibras sensoriais do tipo C.<\/p>\n

Al\u00e9m disso, o TRPV1 tamb\u00e9m \u00e9 expresso em c\u00e9lulas musculares lisas, bem como em c\u00e9lulas endoteliais vasculares, e c\u00e9lulas inflamat\u00f3rias do sistema respirat\u00f3rio.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”40px||40px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.4.4″ locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.4.4″ global_colors_info=”{}”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cbd-aceite-comprar.jpg” alt=”s\u00edndrome do intestino irrit\u00e1vel dos recetores vanyloid” title_text=”S\u00edndrome do intestino irrit\u00e1vel dos recetores vanyloid” _builder_version=”4.9.7″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.9.7″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”35px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”25px” header_2_font_size_phone=”20px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

Recetores vanyl\u00f3ides e s\u00edndrome do intestino irrit\u00e1vel<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.7″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n

A s\u00edndrome do intestino irrit\u00e1vel \u00e9 uma desordem intestinal que aparece sem altera\u00e7\u00f5es estruturais ou bioqu\u00edmicas.<\/strong> \u00c9 uma doen\u00e7a que se caracteriza por dor abdominal, incha\u00e7o, bem como altera\u00e7\u00f5es nos h\u00e1bitos intestinais.<\/p>\n

Tamb\u00e9m \u00e9 comum que ocorram altera\u00e7\u00f5es nas caracter\u00edsticas dos movimentos intestinais. Mas, neste momento, a patog\u00e9nese desta s\u00edndrome n\u00e3o \u00e9 inteiramente clara. A informa\u00e7\u00e3o que temos sobre isso indica que a hipersensibilidade visceral \u00e9 um fator chave na gera\u00e7\u00e3o da dor.<\/p>\n

Pesquisas a este respeito revelaram que a express\u00e3o de TRPV1 em fibras nervosas, apresentou um aumento significativo no tecido do c\u00f3lon em<\/strong> pessoas que sofrem de s\u00edndrome do intestino irrit\u00e1vel. O interessante \u00e9 que este regulamento ascendente est\u00e1 positivamente relacionado com a gravidade da dor no abd\u00f3men.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.8.2″ background_color=”#00a88d” width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/07\/receptores-vaniloides-pancreatitis.jpg” alt=”pancreatite dos recetores vanyl\u00f3ides” title_text=”pancreatite dos recetores vanyl\u00f3ides” force_fullwidth=”on” _builder_version=”4.9.7″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.8.2″ background_enable_color=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_cta button_url=”#top” _builder_version=”4.10.8″ header_font=”|800|||||||” header_text_color=”#ffffff” header_font_size=”35px” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” header_font_size_tablet=”25px” header_font_size_phone=”20px” header_font_size_last_edited=”on|desktop” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n

pancreatite<\/h3>\n

A pancreatite ocorre quando a inflama\u00e7\u00e3o ocorre no p\u00e2ncreas.<\/strong> Este \u00e9 um \u00f3rg\u00e3o que tem fun\u00e7\u00f5es ex\u00f3crinas e end\u00f3crinas. A s\u00edntese normal, o armazenamento e a secre\u00e7\u00e3o das enzimas digestivas s\u00e3o fundamentais para manter o p\u00e2ncreas saud\u00e1vel.<\/p>\n

Estudos indicam que recetores de vaniloide s\u00e3o encontrados em fibras nervosas perto do acino do p\u00e2ncreas.<\/strong> Estas s\u00e3o as c\u00e9lulas encontradas no p\u00e2ncreas, respons\u00e1veis pela produ\u00e7\u00e3o do suco pancre\u00e1tico, utilizado para a digest\u00e3o dos alimentos<\/a>.<\/p>\n

Estas investiga\u00e7\u00f5es constataram que a express\u00e3o e a fun\u00e7\u00e3o do TRPV1 s\u00e3o reguladas de forma positiva na redu\u00e7\u00e3o da dor visceral. Estudos anteriores demonstraram que os danos inflamat\u00f3rios podem libertar agonistas end\u00f3genos de TRPV1 no p\u00e2ncreas.<\/p>\n

Tamb\u00e9m foi descoberto que a ativa\u00e7\u00e3o do recetor trpv1 est\u00e1 relacionada com a produ\u00e7\u00e3o de inflama\u00e7\u00e3o e dor pancre\u00e1tica.<\/strong><\/p>\n

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Hipertens\u00e3o<\/h3>\n

\u00c9 uma doen\u00e7a causada por intera\u00e7\u00f5es gen\u00e9ticas e ambientais,<\/strong>que produzem mudan\u00e7as na fun\u00e7\u00e3o e estrutura do cora\u00e7\u00e3o, bem como no sistema cardiovascular.<\/p>\n

Estudos a este respeito revelam que os recetores de vaniloide est\u00e3o fortemente envolvidos na dete\u00e7\u00e3o de flutua\u00e7\u00f5es da tens\u00e3o arterial. Verificou-se que o recetor TRPV1 \u00e9 expresso nas fibras nervosas e terminais na camada de tecido conjuntivo da aorta ascendente,<\/strong>do arco a\u00f3rtico e das fibras aferentes nos n\u00f3dulos.<\/p>\n

Al\u00e9m disso, estes receptores podem ser considerados como mecanosensores intravasculares que podem regular a press\u00e3o sangu\u00ednea<\/a> detectando altera\u00e7\u00f5es na press\u00e3o mec\u00e2nica.<\/p>\n

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Itens relacionados<\/h4>\n

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5% CDB<\/a><\/p>\n

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20% CDB<\/a><\/p>\n

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B\u00e1lsamo de Cura<\/a><\/p>\n

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Crema dolor muscular<\/a><\/p>\n

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Creme de m\u00e3os<\/a><\/p>\n

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Creme noturno<\/a><\/p>\n

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box_shadow_color__hover=”#e14a00″][\/et_pb_button][et_pb_button button_url=”https:\/\/higeacbd.com\/pt-pt\/loja\/oleos” button_text=”\u00d3leos” _builder_version=”4.13.1″ _dynamic_attributes=”button_url” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” custom_margin_phone=”||60px||false|false” custom_margin_last_edited=”off|tablet” custom_padding=”1px|0px|1px|0px|true|true” custom_padding_tablet=”14px||14px||true|true” custom_padding_phone=”1px||1px||true|true” custom_padding_last_edited=”off|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#00a88d” locked=”off” global_colors_info=”{}” button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#ffffff” box_shadow_color__hover_enabled=”off|hover” box_shadow_color__hover=”#e14a00″][\/et_pb_button][et_pb_button button_url=”https:\/\/higeacbd.com\/pt-pt\/loja\/cremes” button_text=”Cremes” _builder_version=”4.13.1″ _dynamic_attributes=”button_url” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” custom_margin_phone=”||60px||false|false” custom_margin_last_edited=”off|tablet” custom_padding=”1px|0px|1px|0px|true|true” custom_padding_tablet=”14px||14px||true|true” custom_padding_phone=”1px||1px||true|true” custom_padding_last_edited=”off|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#00a88d” locked=”off” global_colors_info=”{}” button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#ffffff” box_shadow_color__hover_enabled=”off|hover” box_shadow_color__hover=”#e14a00″][\/et_pb_button][et_pb_blurb title=”A minha conta” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE0In19@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Plano de amigo” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE1NjE0In19@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”CBD por grosso” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjUyMDEifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Sexta-feira Negra” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjEyODY0In19@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.5.1″ background_color=”#00205c” custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop” global_colors_info=”{}”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#ffffff” header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”1.8em” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Guias<\/h4>\n

[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07-2.png” alt=”s\u00edmbolo do higea” title_text=”spice-shop-07″ _builder_version=”4.5.1″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb title=”Combate \u00e0 ansiedade” url=”https:\/\/higeacbd.com\/pt-pt\/combate-a-ansiedade” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Como tomar \u00f3leo de CDB” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjUzMiJ9fQ==@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”O que \u00e9 a CDB” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjU4NyJ9fQ==@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Benef\u00edcios da CDB” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjY1OSJ9fQ==@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”CBD e CBDA” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE5NjgifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Melhor CDB” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIxNDgifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Estudos cient\u00edficos” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTgifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Antidepressivos” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjM3MTQxIn19@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop” global_colors_info=”{}”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#ffffff” header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”1.8em” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Saiba mais<\/h4>\n

[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07-2.png” alt=”s\u00edmbolo do higea” title_text=”spice-shop-07″ _builder_version=”4.5.1″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb title=”Blog” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6Ijc3NyJ9fQ==@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Animais de estima\u00e7\u00e3o da CDB” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE4OTgifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Citoquinas” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE5OTkifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Terpenos” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI3NDEifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Extrac\u00e7\u00e3o da CDB” url=”https:\/\/higeacbd.com\/pt-pt\/aceites\/metodos-de-extracao-cbd” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”\u00d3leos veiculares” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIzNzcifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”O que s\u00e3o flavon\u00f3ides” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIyOTMifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.4.9″ global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.4.4″ background_color=”#ffffff” custom_padding=”80px|60px|80px|60px|true|true” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#000000″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Aviso legal e pol\u00edtica de privacidade<\/h4>\n

[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png” alt=”s\u00edmbolo do higea” title_text=”s\u00edmbolo do higea” _builder_version=”4.5.1″ locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#000000″ icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

AVISO LEGAL<\/a><\/p>\n

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POL\u00cdTICA DE DEVOLU\u00c7\u00c3O<\/a><\/p>\n

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