[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Products” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”20px||11px||false|false”][et_pb_row _builder_version=”4.5.1″ custom_padding=”8px||17px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.6″ text_font=”|500|||||||” text_text_color=”#000000″ quote_font=”||||||||” header_font=”||||||||” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.4em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||12px|||”]<\/p>\n
Gra\u00e7as a isso criamos os medicamentos que nos ajudam a curar os nossos sintomas e doen\u00e7as. Sabias que uma droga consiste em duas partes? A primeira \u00e9 a droga que \u00e9 a subst\u00e2ncia ativa<\/strong> que ir\u00e1 agir sobre o objetivo terap\u00eautico. A outra parte \u00e9 composta por excipientes que \u00e9 tudo o que rodeia a droga e ajuda-o a viajar pelo nosso corpo at\u00e9 chegar ao alvo terap\u00eautico. Um exemplo de excipientes s\u00e3o as c\u00e1psulas sol\u00faveis contidas nos f\u00e1rmacos. S\u00e3o lentamente desfeitos nos nossos est\u00f4magos libertando gradualmente a subst\u00e2ncia ativa para que seja absorvida de uma forma ideal. Gra\u00e7as a isso criamos os medicamentos que nos ajudam a curar os nossos sintomas e doen\u00e7as. Sabias que uma droga consiste em duas partes? A primeira \u00e9 a droga que \u00e9 a subst\u00e2ncia ativa que ir\u00e1 agir sobre o objetivo terap\u00eautico. A outra parte \u00e9 composta por excipientes que \u00e9 tudo o que rodeia a droga e ajuda-o a viajar pelo nosso corpo at\u00e9 chegar ao alvo terap\u00eautico. Um exemplo de excipientes s\u00e3o as c\u00e1psulas sol\u00faveis contidas nos f\u00e1rmacos. S\u00e3o lentamente desfeitos nos nossos est\u00f4magos libertando gradualmente a subst\u00e2ncia ativa para que seja absorvida de uma forma ideal. <\/p>\n Na farmacologia, antes de estudar o mecanismo de a\u00e7\u00e3o dos f\u00e1rmacos \u00e9 muito importante compreender dois conceitos principais:<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Produtos” _builder_version=”4.7.7″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_module=”16824″][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default” background_enable_color=”off”][et_pb_shop type=”best_selling” posts_number=”8″ show_pagination=”on” module_class=”custom-shop” _builder_version=”4.8.1″ _module_preset=”default” title_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false”][\/et_pb_shop][et_pb_signup mailchimp_list=”higeacbd|5b4d14cf0e” first_name_field=”off” last_name_field=”off” title=”Inscreva-se e receba um desconto de 10%” _builder_version=”4.8.1″ header_level=”h4″ header_font=”|800|||||||” header_text_align=”center” header_text_color=”#000000″ header_font_size=”35px” header_line_height=”1.2em” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” button_custom_padding=”18px|0px|18px|0px|true|true” button_custom_padding_tablet=”14px||14px||true|true” button_custom_padding_phone=”12px||12px||true|true” button_custom_padding_last_edited=”on|phone” background_layout=”light” header_font_size_tablet=”25px” header_font_size_phone=”20px” header_font_size_last_edited=”on|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style_button=”preset4″ box_shadow_horizontal_button=”0px” box_shadow_vertical_button=”2px” box_shadow_color_button=”#00a88d” button_text_color__hover=”#28221d” button_text_color__hover_enabled=”on|hover” box_shadow_color_button__hover=”#000000″ box_shadow_color_button__hover_enabled=”on|desktop”][\/et_pb_signup][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” background_color=”#f3f3f1″ custom_padding=”14px||27px|||”][et_pb_row _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”12px||13px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.6.6″ _module_preset=”default” header_2_font=”|800|||||||” header_2_text_align=”center” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_font=”|800|||||||” header_3_text_align=”center” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||-5px|||” custom_padding=”||0px|||”]<\/p>\n A sua etimologia prov\u00e9m do grego e refere-se ao movimento das drogas. Em termos gerais, a farmacocin\u00e9tica \u00e9 o que o corpo faz com as drogas.<\/strong> Descreve a absor\u00e7\u00e3o, distribui\u00e7\u00e3o, metabolismo e excre\u00e7\u00e3o de compostos. \u00c9 por isso que muitas vezes quando vamos ao m\u00e9dico e nos \u00e9 prescrito um medicamento sempre nos fazem algumas perguntas que visam detetar se h\u00e1 algum dos nossos funcionamentos internos que pode afetar a farmacocin\u00e9tica do medicamento que vamos tomar. Por exemplo, se tivermos problemas renais, hep\u00e1ticos ou de circula\u00e7\u00e3o que interfiram com a circula\u00e7\u00e3o normal do f\u00e1rmaco atrav\u00e9s do nosso corpo.<\/p>\n Portanto, quando falamos de farmacocin\u00e9tica, focamo-nos no estudo da entrada e sa\u00edda da droga no nosso corpo.<\/p>\n Quando uma subst\u00e2ncia entra \u00e9 importante saber para que lado entra e a que velocidade. As vias de administra\u00e7\u00e3o mais comuns s\u00e3o orais e intravenosas. Depois de sabermos para que lado o f\u00e1rmaco entrou e qu\u00e3o r\u00e1pido, ou seja, sabemos a sua biodisponibilidade,<\/a>podemos prosseguir com o estudo da sua absor\u00e7\u00e3o. A absor\u00e7\u00e3o compreende o processo durante o qual o composto viaja da rota da administra\u00e7\u00e3o para o plasma. Como \u00faltimo processo de entrada \u00e9 importante saber como a droga \u00e9 distribu\u00edda pelo nosso corpo.<\/p>\n Uma vez que o f\u00e1rmaco tenha sido absorvido e distribu\u00eddo estamos interessados em saber como sai do corpo. A elimina\u00e7\u00e3o dos compostos pode ser por biotransforma\u00e7\u00e3o, ou seja, pelo corpo que os transforma ou por excre\u00e7\u00e3o.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/10\/farmacodinamica.jpg” alt=”farmacodin\u00e2mica” title_text=”farmacodin\u00e2mica” force_fullwidth=”on” _builder_version=”4.6.6″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”O que \u00e9 farmacodin\u00e2mica ou farmacodin\u00e2mica?” button_url=”#top” _builder_version=”4.6.6″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n Para a sua etimologia tamb\u00e9m o grego refere-se \u00e0 pot\u00eancia das drogas. Ou seja, o estudo do que a droga faz ao nosso corpo.<\/strong> Uma vez que o f\u00e1rmaco atinge o alvo terap\u00eautico, ter\u00e1 que interagir com recetores celulares para causar um efeito nas c\u00e9lulas.<\/p>\n Cada indiv\u00edduo tem uma resposta diferente \u00e0s drogas. No entanto, a distribui\u00e7\u00e3o estat\u00edstica da resposta aos f\u00e1rmacos da popula\u00e7\u00e3o \u00e9 normal (ou sino gaussiano). Nesta distribui\u00e7\u00e3o vamos encontrar uma m\u00e9dia no centro do capot, casos extremos de hiporeatividade ou hiperreactividade nas extremidades da curva e tamb\u00e9m casos idiossincr\u00e1ticos que est\u00e3o fora da curva.<\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” background_color=”#f3f3f1″ custom_padding=”14px||27px|||”][et_pb_row _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”12px||13px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.9.1″ _module_preset=”default” header_2_font=”|800|||||||” header_2_text_align=”center” header_2_font_size=”35px” header_2_line_height=”1.2em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||-5px|||” custom_padding=”||0px|||” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n Al\u00e9m disso, se o f\u00e1rmaco for administrado repetidamente e for necess\u00e1rio aumentar a dose, fala-se em gerar toler\u00e2ncia.<\/a> <\/strong> Quanto mais tivermos de aumentar a dosagem para obter os efeitos desejados, mais tolerante e dependente a droga torna-se o indiv\u00edduo.<\/p>\n O estudo dos efeitos secund\u00e1rios dos f\u00e1rmacos corresponde ao<\/strong> ramo da farmacodin\u00e2mica. Mesmo que os efeitos secund\u00e1rios n\u00e3o sejam adversos, \u00e9 crucial conhec\u00ea-los. Por exemplo, se vamos conduzir \u00e9 melhor n\u00e3o tomar anti-histam\u00ednicos que tenham um efeito sonol\u00eancia. Este n\u00e3o seria adverso se em vez de dirigir queremos dormir \u00e0 noite.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”40px||40px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.4.4″ locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.4.4″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cbd-aceite-comprar.jpg” alt=”toler\u00e2ncia farmacodin\u00e2mica” title_text=”toler\u00e2ncia farmacodin\u00e2mica” _builder_version=”4.6.6″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.6.6″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.6.6″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n A farmacodin\u00e2mica tamb\u00e9m estuda as intera\u00e7\u00f5es de f\u00e1rmacos.<\/strong> Existem rela\u00e7\u00f5es de sinergia em que os efeitos de um ou ambos os f\u00e1rmacos aumentam ou aumentam. O efeito de facilita\u00e7\u00e3o de f\u00e1rmacos tamb\u00e9m \u00e9 amplamente utilizado na farmacologia. Nestes casos, os efeitos de um dos f\u00e1rmacos facilitam a a\u00e7\u00e3o do outro. Por exemplo, o \u00e1cido clabul\u00e2mico \u00e9 usado em conjunto com a penicilina para evitar que as bact\u00e9rias geram resist\u00eancia antibi\u00f3tica.<\/p>\n O estudo da dose em farmacodin\u00e2mica \u00e9 importante para determinar as margens terap\u00eauticas e de seguran\u00e7a de cada f\u00e1rmaco,<\/strong>para saber a partir de que dose o f\u00e1rmaco ter\u00e1 efeito no indiv\u00edduo e a partir de que dose pode ser letal. Gra\u00e7as \u00e0s curvas da dose – resposta podemos saber como cada dose se comporta.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/10\/interaccion-farmacodinamica.jpg” alt=”intera\u00e7\u00e3o farmacodin\u00e2mica” title_text=”intera\u00e7\u00e3o farmacodin\u00e2mica” force_fullwidth=”on” _builder_version=”4.6.6″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”Intera\u00e7\u00e3o farmacodin\u00e2mica” button_url=”#top” _builder_version=”4.6.6″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n A farmacodin\u00e2mica inclui tamb\u00e9m a an\u00e1lise dos mecanismos pelos quais as drogas atuam no nosso corpo.<\/strong> Os f\u00e1rmacos podem atuar em mol\u00e9culas-alvo tais como prote\u00ednas (enzimas, canais de i\u00f5es, mol\u00e9culas de transporte ou recetores); O ADN; ou articula\u00e7\u00f5es silenciosas (prote\u00ednas plasm\u00e1ticas ou liga\u00e7\u00e3o espec\u00edfica). Al\u00e9m disso, h\u00e1 drogas que n\u00e3o atuam em mol\u00e9culas-alvo. Por exemplo, quando sentimos acidez e tomamos um anti\u00e1cido, n\u00e3o agir\u00e1 sobre uma mol\u00e9cula-alvo, mas mudar\u00e1 diretamente o PH do nosso est\u00f4mago para neutralizar os \u00e1cidos.<\/p>\n As intera\u00e7\u00f5es mais comuns na farmacodin\u00e2mica s\u00e3o com recetores.<\/strong> Estas s\u00e3o macromol\u00e9culas que recebem est\u00edmulos e transmitem-nas \u00e0s c\u00e9lulas para gerar um efeito. As drogas podem agir seletivamente para modificar uma fun\u00e7\u00e3o espec\u00edfica da c\u00e9lula onde est\u00e3o a agir. Na farmacologia, a analogia do bloqueio (o recetor) e a chave (o f\u00e1rmaco) s\u00e3o amplamente utilizadas. Se o ligando \u00e9 agonista significa que a fechadura abrir\u00e1 a porta a hormonas ou neurotransmissor. Se for antag\u00f3nico, agir\u00e1 fechando e trancando a porta.<\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.5.1″ custom_margin=”|auto|-2px|auto||” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.5.1″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cual-es-el-mejor-aceite-de-cbd.jpg” alt=”farmacodin\u00e2mica e farmacocin\u00e9tica” title_text=”farmacodin\u00e2mica e farmacocin\u00e9tica” align=”center” _builder_version=”4.6.6″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.6.6″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n Dependendo do tipo de liga\u00e7\u00e3o qu\u00edmica entre o recetor e o ligando (o f\u00e1rmaco) haver\u00e1 passageiros ou efeitos mais duradouros. Quanto mais fraca for a liga\u00e7\u00e3o (por exemplo, uma ponte Van der Waal), mais transit\u00f3rio ser\u00e1 o efeito do f\u00e1rmaco. No entanto, se ocorrem articula\u00e7\u00f5es tipo covalentes (n\u00e3o comuns) s\u00e3o liga\u00e7\u00f5es permanentes com altera\u00e7\u00f5es irrevers\u00edveis das c\u00e9lulas. Neste caso, o recetor n\u00e3o seria reutilizado para a vida e for\u00e7aria o corpo a produzir um novo recetor.<\/p>\n Ao introduzir uma droga ou subst\u00e2ncia no nosso corpo \u00e9 essencial saber como o nosso corpo ir\u00e1 trat\u00e1-lo (farmacocin\u00e9tica) e tamb\u00e9m quais os efeitos que ter\u00e1 no nosso corpo (farmacodin\u00e2mica). Embora o estudo populacional conclua numa distribui\u00e7\u00e3o normal, cada indiv\u00edduo \u00e9 um mundo e \u00e9 por isso que as nossas caracter\u00edsticas idiossincr\u00e1ticas podem afetar a dosagem que devemos tomar para alcan\u00e7ar os efeitos colaterais menos adversos e a maior efic\u00e1cia terap\u00eautica. 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