{"id":10798,"date":"2020-09-14T12:56:24","date_gmt":"2020-09-14T12:56:24","guid":{"rendered":"https:\/\/higeacbd.com\/oleos\/sistema-endocanabinoide\/"},"modified":"2025-03-24T12:00:46","modified_gmt":"2025-03-24T12:00:46","slug":"sistema-endocanabinoide","status":"publish","type":"post","link":"https:\/\/higeacbd.com\/pt-pt\/datos\/sistema-endocanabinoide","title":{"rendered":"Sistema endocanabin\u00f3ide"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Hero&#8221; _builder_version=&#8221;4.6.1&#8243; background_color=&#8221;rgba(255,255,255,0.65)&#8221; background_image=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/09\/cannabinoide.jpg&#8221; background_blend=&#8221;soft-light&#8221; custom_padding=&#8221;3vw||1vw|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_cta title=&#8221;Sistema endocanabin\u00f3ide&#8221; _builder_version=&#8221;4.6.1&#8243; header_level=&#8221;h1&#8243; header_font=&#8221;|800|||||||&#8221; header_font_size=&#8221;45px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;|800|||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;20px&#8221; body_line_height=&#8221;1.6em&#8221; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#00a88d&#8221; button_border_width=&#8221;8px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;60px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;light&#8221; animation_direction=&#8221;bottom&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;50px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; button_text_color_hover=&#8221;#ffffff&#8221; button_border_radius_hover=&#8221;66px&#8221; button_letter_spacing_hover=&#8221;1px&#8221; button_bg_color_hover=&#8221;rgba(47,56,84,0.9)&#8221; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;on&#8221; button_text_color__hover=&#8221;#ffffff&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;on&#8221; button_border_radius__hover=&#8221;66px&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;on&#8221; button_letter_spacing__hover=&#8221;1px&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;on&#8221; button_bg_color__hover=&#8221;rgba(47,56,84,0.9)&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;]O que \u00e9 o <strong>sistema endocanabin\u00f3ide e como<\/strong> funciona?[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Products&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;20px||11px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.5.1&#8243; custom_padding=&#8221;8px||17px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.14.5&#8243; text_font=&#8221;|500|||||||&#8221; text_text_color=&#8221;#000000&#8243; quote_font=&#8221;||||||||&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.4em&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||12px|||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p>Em 1988, durante um  <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2848184\/\" target=\"_blank\" rel=\"noopener noreferrer\">subsidiado pelo governo americano do St. Louis. Faculdade de Medicina da Universidade de Louis<\/a>Allyn Howlett e William Devane determinaram que o c\u00e9rebro dos mam\u00edferos tem certos <a href=\"https:\/\/higeacbd.com\/pt-pt?p=86725\" title=\"Receptores cannabinoides\">receptores canabin\u00f3ides<\/a> (CB1R) que reagem a compostos encontrados em plantas de can\u00e1bis. Na verdade, estes recetores s\u00e3o o tipo de neurotransmissor que mais abunda no c\u00e9rebro.<\/p>\n<p>Esta descoberta cient\u00edfica impulsionou o investimento na investiga\u00e7\u00e3o sobre o potencial da can\u00e1bis. Em 1990, <a href=\"https:\/\/www.nature.com\/articles\/346561a0\" target=\"_blank\" rel=\"noopener noreferrer\">uma equipa cient\u00edfica liderada por Lisa Matsuda conseguiu mapear a sequ\u00eancia de ADN de<\/a> um destes recetores canabin\u00f3ides no c\u00e9rebro. As experi\u00eancias foram conduzidas com ratinhos geneticamente modificados que careciam do recetor acoplado pela prote\u00edna G: Efetivamente, o canabidiol THC que foi administrado a estes ratos n\u00e3o teve efeito, provando assim que o THC ativa <a href=\"https:\/\/higeacbd.com\/pt-pt\/beneficios-pt-pt\/o-efeito-do-cbd-no-cerebro\" title=\"Efecto CBD cerebro\">recetores canabin\u00f3ides no c\u00e9rebro.<\/a> Durante este mesmo estudo foi identificado outro recetor canabin\u00f3ide que foi enfeitizado como CB2R e est\u00e1 presente em diferentes tecidos em todo o nosso corpo predominando no sistema imunit\u00e1rio e no sistema nervoso.<\/p>\n<p>Com v\u00e1rios receptores canabinoides CB1R e CB2R j\u00e1 identificados, ficou claro que <strong>em cada mam\u00edfero existe uma complexa teia de receptores canabinoides que reagem com <a href=\"https:\/\/higeacbd.com\/pt-pt?p=86736\" title=\"Endocannabinoides qu\u00e9 son\">endocanabinoides<\/a><\/strong> produzidos naturalmente em nosso corpo. Este \u00e9 o sistema endocanabin\u00f3ide e est\u00e1 localizado n\u00e3o s\u00f3 no sistema nervoso e no c\u00e9rebro, mas <a href=\"https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/09\/Human-CB1-Receptor-Isoforms-present-in-Hepatocytes-and-%CE%B2-cells-are-Involved-in-Regulating-Metabolism.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">tamb\u00e9m h\u00e1 evid\u00eancias cient\u00edficas de que os mam\u00edferos t\u00eam recetores canabin\u00f3ides em outros tecidos org\u00e2nicos, como o f\u00edgado e o p\u00e2ncreas.<\/a><\/p>\n<p>Neste artigo falaremos sobre <strong>o recetor canabin\u00f3ide <\/strong>e tamb\u00e9m sobre o <strong>sistema endocanabin\u00f3ide.<\/strong> De facto, a ECS \u00e9 considerada um complexo sistema de sinaliza\u00e7\u00e3o celular, que foi descoberto no in\u00edcio da d\u00e9cada de 1990 por cientistas que pesquisavam o THC.<\/p>\n<p>Como sabemos, o THC \u00e9 um canabin\u00f3ide bem conhecido, uma vez que \u00e9 um composto que est\u00e1 presente na can\u00e1bis. \u00c9 importante notar que os investigadores ainda est\u00e3o a tentar compreender completamente o sistema endocanabin\u00f3ide, bem <strong>como os recetores canabin\u00f3ides,<\/strong>incluindo o recetor cb1. O que se sabe at\u00e9 \u00e0 data \u00e9 que tem um papel fundamental na regula\u00e7\u00e3o de um vasto leque de fun\u00e7\u00f5es e processos nas nossas ag\u00eancias, incluindo:<\/p>\n<ul>\n<li>O clima<\/li>\n<li>Reprodu\u00e7\u00e3o e fertilidade<\/li>\n<li>Qualidade do sono<\/li>\n<li>Apetite<\/li>\n<li>Mem\u00f3ria<\/li>\n<\/ul>\n<p>\u00c9 interessante mencionar que o sistema endocanabin\u00f3ide (ECS) existe, e est\u00e1 ativo no nosso corpo, mesmo sem a necessidade de usar can\u00e1bis. Aqui est\u00e1 um pouco mais de conversa sobre este sistema, e a fun\u00e7\u00e3o dos recetores.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=&#8221;Produtos&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_module=&#8221;16824&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_shop type=&#8221;best_selling&#8221; posts_number=&#8221;8&#8243; show_pagination=&#8221;on&#8221; module_class=&#8221;custom-shop&#8221; _builder_version=&#8221;4.13.0&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|700|||||||&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_shop][et_pb_signup mailchimp_list=&#8221;higeacbd|5b4d14cf0e&#8221; first_name_field=&#8221;off&#8221; last_name_field=&#8221;off&#8221; title=&#8221;Inscreva-se e receba um desconto de 10%&#8221; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.13.0&#8243; header_level=&#8221;h4&#8243; header_font=&#8221;|800|||||||&#8221; header_text_align=&#8221;center&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;35px&#8221; header_line_height=&#8221;1.2em&#8221; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#00a88d&#8221; button_bg_color=&#8221;rgba(0,0,0,0)&#8221; button_border_width=&#8221;0px&#8221; button_border_radius=&#8221;0px&#8221; button_letter_spacing=&#8221;2px&#8221; button_font=&#8221;|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; button_custom_padding=&#8221;18px|0px|18px|0px|true|true&#8221; button_custom_padding_tablet=&#8221;14px||14px||true|true&#8221; button_custom_padding_phone=&#8221;12px||12px||true|true&#8221; button_custom_padding_last_edited=&#8221;on|phone&#8221; background_layout=&#8221;light&#8221; header_font_size_tablet=&#8221;25px&#8221; header_font_size_phone=&#8221;20px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; button_text_size_tablet=&#8221;14px&#8221; button_text_size_phone=&#8221;12px&#8221; button_text_size_last_edited=&#8221;on|phone&#8221; box_shadow_style_button=&#8221;preset4&#8243; box_shadow_horizontal_button=&#8221;0px&#8221; box_shadow_vertical_button=&#8221;2px&#8221; box_shadow_color_button=&#8221;#00a88d&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover=&#8221;#28221d&#8221; button_text_color__hover_enabled=&#8221;on|hover&#8221; box_shadow_color_button__hover=&#8221;#000000&#8243; box_shadow_color_button__hover_enabled=&#8221;on|desktop&#8221;][\/et_pb_signup][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;14px||27px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;12px||13px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;35px&#8221; header_2_line_height=&#8221;1.2em&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||-5px|||&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Passaram-se 30 anos desde estas descobertas e ainda h\u00e1 muitas quest\u00f5es a resolver relativamente ao sistema endocanabin\u00f3ide. Por um lado, a legisla\u00e7\u00e3o em vigor nas \u00faltimas d\u00e9cadas estigmatizou a can\u00e1bis devido aos seus efeitos psicotr\u00f3picos e, consequentemente, tem abrandado o investimento em estudos cient\u00edficos relacionados. No entanto, por outro lado, aplica\u00e7\u00f5es e experi\u00eancias emp\u00edricas nos \u00faltimos anos conseguiram quebrar estas barreiras para que a ci\u00eancia possa <a title=\"Estudios cient\u00edficos sobre los beneficios del CBD\" href=\"https:\/\/higeacbd.com\/pt-pt\/estudos-cientificos-sobre-os-beneficios-da-cdb\">decifrar por que tais efeitos positivos s\u00e3o descritos ao consumir certos canabin\u00f3ides.<\/a> O <a title=\"Crecimiento del mercado de aceites CBD\" href=\"https:\/\/higeacbd.com\/pt-pt\/datos\/crescimento-do-mercado-petrolifero-do-cbd\">mercado de derivados da can\u00e1bis est\u00e1 em expans\u00e3o e<\/a> dever\u00e1 subir para 22 mil milh\u00f5es de d\u00f3lares nos pr\u00f3ximos anos.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10392859\/\" target=\"_blank\" rel=\"noopener noreferrer\">Recetores cannab\u00f4\u00f3ides foram encontrados no g\u00e9nero Hydra,<\/a>um organismo muito primitivo, por isso os cientistas sentem que <strong>o sistema endocanabin\u00f3ide tem mais de 500 milh\u00f5es<\/strong> de anos na hist\u00f3ria da evolu\u00e7\u00e3o.<\/p>\n<h2>Como funciona o sistema endocanabin\u00f3ide (ECS) ? Recetores endocanabin\u00f3ides<\/h2>\n<p>O sistema endocanabin\u00f3ide \u00e9 composto por tr\u00eas componentes centrais, que s\u00e3o: <strong>endocanabin\u00f3ides,<\/strong> <strong>recetores<\/strong>canabin\u00f3ides <strong> e <strong>enzimas.<\/strong><\/strong> Vamos ver mais de perto o que cada um destes componentes consiste.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;12px||13px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.13.1&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;35px&#8221; header_2_line_height=&#8221;1.2em&#8221; header_3_font=&#8221;|800|||||||&#8221; header_3_text_align=&#8221;center&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||-5px|||&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Endocanabin\u00f3ides<\/h3>\n<p>Os endocanabin\u00f3ides tamb\u00e9m s\u00e3o conhecidos como canabin\u00f3ides end\u00f3genos. Estas s\u00e3o basicamente mol\u00e9culas que o nosso corpo produz, e que s\u00e3o muito semelhantes aos canabin\u00f3ides encontrados na can\u00e1bis. At\u00e9 \u00e0 data, os investigadores conseguiram identificar dois endocanabin\u00f3ides-chave, que s\u00e3o:<\/p>\n<ul>\n<li><a href=\"https:\/\/higeacbd.com\/pt-pt\/dados\/cdb-e-anandamida\" title=\"Anandamida\">Anandamida<\/a> (AEA)<\/li>\n<li>2-araquidonoilglycerol (2-AG)<\/li>\n<\/ul>\n<p>Ambas as mol\u00e9culas visam ajudar a manter as fun\u00e7\u00f5es internas dos nossos organismos sem conflitos. Uma coisa importante a notar \u00e9 que o nosso corpo produz endocanabin\u00f3ides conforme necess\u00e1rio. Por causa disso, \u00e9 muitas vezes muito dif\u00edcil determinar quais s\u00e3o os n\u00edveis t\u00edpicos de cada mol\u00e9cula.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.14.2&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;35px&#8221; header_2_line_height=&#8221;1.2em&#8221; header_3_font=&#8221;|800|||||||&#8221; header_3_text_align=&#8221;center&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||-5px|||&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Recetores endocanabin\u00f3ides<\/h3>\n<p>Estes recetores tamb\u00e9m s\u00e3o produzidos pelo nosso corpo. Na verdade, s\u00e3o encontrados em todos os nossos corpos. A fun\u00e7\u00e3o dos recetores \u00e9<strong> ligar-se aos endocanabin\u00f3ides para dizer ao sistema endocanabin\u00f3ide para agir.<\/strong> Neste caso, foram identificados dois principais recetores canabin\u00f3ides:<\/p>\n<ul>\n<li>O primeiro deles \u00e9 o <strong>recetor cb1,<\/strong>que podemos encontrar particularmente no sistema nervoso central do nosso corpo.<\/li>\n<li>O segundo \u00e9 o <strong>receptor cb2<\/strong>, que neste caso est\u00e1 localizado principalmente no <a href=\"https:\/\/higeacbd.com\/pt-pt\/doencas\/tiques-nervosos-e-cdb\" title=\"Tics nerviosos CBD\">sistema nervoso<\/a> perif\u00e9rico do nosso corpo, mais especificamente nas c\u00e9lulas imunit\u00e1rias.<\/li>\n<\/ul>\n<p>Aqui vale a pena<strong> notar que os endocanabin\u00f3ides podem ligar-se a qualquer um destes dois recetores canabin\u00f3ides.<\/strong> No entanto, os efeitos resultantes dependem do local onde o recetor est\u00e1 localizado, bem como do tipo de endocanabin\u00f3ide que une.<\/p>\n<p>Por outras palavras, os endocanabin\u00f3ides podem ligar-se aos recetores canabin\u00f3ides cb1 num nervo espinhal, com o objetivo de proporcionar al\u00edvio da dor. Tamb\u00e9m \u00e9 poss\u00edvel que outros endocanabin\u00f3ides possam ligar-se aos recetores canabin\u00f3ides cb2 nas suas c\u00e9lulas imunit\u00e1rias, o que indica que o corpo est\u00e1 a sofrer inflama\u00e7\u00e3o.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;12px||13px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;35px&#8221; header_2_line_height=&#8221;1.2em&#8221; header_3_font=&#8221;|800|||||||&#8221; header_3_text_align=&#8221;center&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||-5px|||&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Enzimas<\/h3>\n<p>Quanto \u00e0s enzimas,<strong> s\u00e3o mol\u00e9culas org\u00e2nicas respons\u00e1veis pela decompor os endocanabin\u00f3ides<\/strong>uma vez que tenham desempenhado a sua fun\u00e7\u00e3o. Dentro do sistema endocanabin\u00f3ide encontramos principalmente dois tipos de enzimas que s\u00e3o respons\u00e1veis pela realiza\u00e7\u00e3o desta tarefa:<\/p>\n<ul>\n<li>O \u00e1cido gordo hidrolase amide enzima, que decomp\u00f5e o anandamida (AEA).<\/li>\n<li>A lipase \u00e1cido monoacilglicerol enzim\u00e1tico, que neste caso decomp\u00f5e 2-aracydonoylglicerol (2-AG).<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;35px&#8221; header_2_line_height=&#8221;1.2em&#8221; header_3_font=&#8221;|800|||||||&#8221; header_3_text_align=&#8221;center&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||-5px|||&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Agonista inversa e antagonista invertido<\/h3>\n<p>O agonista \u00e9 um f\u00e1rmaco que tem a capacidade de imitar os efeitos dos neurotransmissor end\u00f3genos. Por seu lado, o agonista inverso \u00e9 tamb\u00e9m uma droga, s\u00f3 que neste caso produz a a\u00e7\u00e3o oposta ao agonista. Ou seja, produz efeitos opostos aos de um neurotransmissor.<\/p>\n<p>Deve tamb\u00e9m dizer-se que os antagonistas s\u00e3o respons\u00e1veis por bloquear os efeitos dos agonistas e reverter os agonistas.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;0px|0px|0px|0px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; make_equal=&#8221;on&#8221; admin_label=&#8221;CTA Row&#8221; module_class=&#8221; et_pb_row_fullwidth&#8221; _builder_version=&#8221;4.5.1&#8243; width=&#8221;100%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;&#8221; width_last_edited=&#8221;on|desktop&#8221; max_width=&#8221;100%&#8221; max_width_tablet=&#8221;100%&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px|0px|0px|0px&#8221; make_fullwidth=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/09\/sistema-endocannabinoide.jpg&#8221; alt=&#8221;sistema endocanabin\u00f3ide&#8221; title_text=&#8221;sistema endocanabin\u00f3ide&#8221; force_fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.6.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_cta title=&#8221;O sistema endocanabin\u00f3ide em geral&#8221; button_url=&#8221;#top&#8221; _builder_version=&#8221;4.6.1&#8243; header_font=&#8221;|800|||||||&#8221; header_text_color=&#8221;#ffffff&#8221; body_font=&#8221;Montserrat|500|||||||&#8221; body_text_color=&#8221;#ffffff&#8221; body_link_text_color=&#8221;#000000&#8243; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#2f3854&#8243; button_border_width=&#8221;10px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;60px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; button_alignment=&#8221;left&#8221; text_orientation=&#8221;left&#8221; max_width=&#8221;580px&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; module_alignment=&#8221;left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;40px|60px|2px|60px||&#8221; button_text_color_hover=&#8221;#2f3854&#8243; button_border_radius_hover=&#8221;66px&#8221; button_letter_spacing_hover=&#8221;1px&#8221; button_bg_color_hover=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;on&#8221; button_text_color__hover=&#8221;#2f3854&#8243; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;on&#8221; button_border_radius__hover=&#8221;66px&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;on&#8221; button_letter_spacing__hover=&#8221;1px&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;on&#8221; button_bg_color__hover=&#8221;#ffffff&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;]<\/p>\n<p>Todos os humanos e mam\u00edferos t\u00eam um sistema endocanabin\u00f3ide. \u00c9 <strong>uma teia de recetores e neurotransmissor que regula as rea\u00e7\u00f5es fisiol\u00f3gicas em resposta ao nosso ambiente<\/strong> e est\u00e1 presente em diferentes \u00f3rg\u00e3os do nosso corpo, mas acima de tudo no nosso c\u00e9rebro e atrav\u00e9s do nosso sistema nervoso. Em termos gerais, podemos dizer que o sistema endocanabin\u00f3ide \u00e9 respons\u00e1vel por fazer com que <strong>todos os sistemas funcionem harmoniosamente no nosso corpo para manter a homeostase.<\/strong> \u00c9 um sistema <strong>de neurotransmiss\u00e3o<\/strong> que \u00e9 composto por endocanabin\u00f3ides, enzimas que ajudam a sintetiz\u00e1-los, e os recetores canabin\u00f3ides com os quais se conectam e ativam.<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;14px||27px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;12px||13px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.6.1&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;35px&#8221; header_2_line_height=&#8221;1.2em&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||-5px|||&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>O que s\u00e3o endocanabin\u00f3ides?<\/h2>\n<p>S\u00e3o os canabin\u00f3ides que o seu corpo \u00e9 capaz de produzir e agir <strong>como neuromoduladores presipticamente para sintetizar ou libertar um neurotransmissor na fenda sin\u00e1ptica.<\/strong><\/p>\n<p>At\u00e9 agora foram identificados dois endocanabin\u00f3ides:<\/p>\n<ul>\n<li><strong>Anandamida (AEA)<\/strong>\u00e9 um neurotransmissor derivado de um \u00f3mega \u00f3mega 6 do \u00e1cido gordo essencial. Assim como glutamato, adrenalina ou dopamina aracydonoylethanolamide (AEA) passa pelo sistema nervoso e faz com que os neur\u00f3nios se comuniquem uns com os outros. O seu nome prov\u00e9m do s\u00e2nscrito &#8220;ananda&#8221; que significa felicidade e paz porque \u00e9 respons\u00e1vel por relaxar e tranquilizar. Pode ser encontrado em alguns alimentos, como cacau e em alguns peixes, ouri\u00e7os-do-mar e ovas.<\/li>\n<li><strong>2-araquidonilglicerol (2-AG)<\/strong><\/li>\n<\/ul>\n<p>Embora estes dois endocanabin\u00f3ides tenham sido determinados apenas atualmente, a probabilidade de a lista crescer \u00e9 muito elevada \u00e0 medida que a ci\u00eancia avan\u00e7a no campo. <strong>Os endocanabin\u00f3ides s\u00e3o feitos de fosfol\u00edpidos da membrana,<\/strong>a maioria deles s\u00e3o a combina\u00e7\u00e3o de um \u00e1cido gordo com uma amina t\u00e3o natural combina\u00e7\u00f5es s\u00e3o imensas, uma vez que no nosso corpo existem muitos tipos diferentes de \u00e1cidos gordos e aminas presentes. <\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;40px||40px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.4.4&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.4.4&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/09\/receptores-cannabinoides.jpg&#8221; alt=&#8221;recetores canabin\u00f3ides&#8221; title_text=&#8221;recetores canabin\u00f3ides&#8221; _builder_version=&#8221;4.6.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.4.4&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.6.1&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>O que s\u00e3o recetores canabin\u00f3ides?<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.6.1&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Est\u00e3o espalhados por todo o nosso organismo e os endocanabin\u00f3ides transmitem sinais para que o Sistema Endocanabin\u00f3ide tome medidas.<\/p>\n<p>At\u00e9 agora <strong>s\u00e3o conhecidos dois recetores canabin\u00f3ides:<\/strong><\/p>\n<ul>\n<li><strong>CB1R<\/strong>: <strong>S\u00e3o recetores metab\u00f3licos<\/strong> que predominam no sistema nervoso central, no c\u00e9rebro humano (em outros mam\u00edferos os recetores CB1 est\u00e3o localizados noutros tecidos dos seus organismos). Durante as sinapses neurais, os recetores CB1 <strong>moderam a neurotransmiss\u00e3o excessiva<\/strong> quando os neur\u00f3nios segregam demasiados qu\u00edmicos. Os endocanabin\u00f3ides atuam ent\u00e3o <strong>como inibidores do neurotransmissor, tais como o glutamato (neurotransmissor excitante)<\/strong> para restaurar o equil\u00edbrio. Quando um neurotransmissor excitado \u00e9 segregado da c\u00e9lula pr\u00e9-sin\u00e1ptica, o neurotransmissor conecta-se e ativa o recetor no neur\u00f3nio p\u00f3s-sin\u00e1ptico. Esta estimula\u00e7\u00e3o causa a s\u00edntese e a liberta\u00e7\u00e3o de endocanabin\u00f3ides que viajam de volta atrav\u00e9s da sinapse neural onde se ligam aos recetores CB1 localizados na membrana da c\u00e9lula pr\u00e9-sin\u00e1ptica. Uma vez ativado, o recetor CB1 come\u00e7a a inibir a liberta\u00e7\u00e3o do neurotransmissor estimulante (tal como o glutamato) causando um efeito de relaxamento.<\/li>\n<li><strong>CB2R:<\/strong>Estes recetores canabin\u00f3ides s\u00e3o encontrados no sistema nervoso perif\u00e9rico especialmente em c\u00e9lulas imunit\u00e1rias e no trato intestinal. Os endocanabin\u00f3ides ativam recetores CB2 localizados em membranas celulares. Uma vez ativados, <strong>os recetores CB2 causam rea\u00e7\u00f5es imunes que dependem do tipo de pilha e do seu ambiente.<\/strong> A ativa\u00e7\u00e3o do recetor CB2 inibe a produ\u00e7\u00e3o de citosina inflamat\u00f3ria que gera, entre outros, um efeito anti-inflamat\u00f3rio.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;14px||27px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;12px||13px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;35px&#8221; header_2_line_height=&#8221;1.2em&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||-5px|||&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Quais s\u00e3o as fun\u00e7\u00f5es do sistema endocanabin\u00f3ide?<\/h2>\n<p>Como mencionado no in\u00edcio, ainda n\u00e3o \u00e9 poss\u00edvel determinar com precis\u00e3o como funciona ou quais as fun\u00e7\u00f5es que o sistema endocanabin\u00f3ide (ECS) desempenha. Apesar disso, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5877694\/\" target=\"_blank\" rel=\"noopener\">um estudo publicado em 2018,<\/a>relacionou este sistema com uma s\u00e9rie de processos no nosso corpo. Entre elas est\u00e3o as seguintes:<\/p>\n<ul>\n<li>Metabolismo<\/li>\n<li>Dor cr\u00f3nica<\/li>\n<li>Apetite e digest\u00e3o<\/li>\n<li>Humor<\/li>\n<li>Inflama\u00e7\u00e3o e outras respostas do sistema imunol\u00f3gico<\/li>\n<li>Controlo motor<\/li>\n<li>Aprendizagem e mem\u00f3ria<\/li>\n<li>Forma\u00e7\u00e3o muscular, remodela\u00e7\u00e3o e crescimento \u00f3sseo<\/li>\n<li>Fun\u00e7\u00e3o do sistema cardiovascular<\/li>\n<li>Stress e nervos<\/li>\n<li>A fun\u00e7\u00e3o do sistema reprodutivo<\/li>\n<\/ul>\n<p>O interessante sobre estas fun\u00e7\u00f5es e processos no corpo \u00e9 <strong>que todos contribuem para a homeostase,<\/strong>o que permite ao corpo manter uma condi\u00e7\u00e3o interna est\u00e1vel. Por outras palavras, se uma condi\u00e7\u00e3o externa, como a dor causada por les\u00f5es, alterar a homeostase do corpo, o sistema endocanabin\u00f3ide \u00e9 ativado para que o corpo regresse ao seu funcionamento normal.<\/p>\n<p>Por isso, muitos cientistas e investigadores consideram que o principal papel do sistema endocanabin\u00f3ide \u00e9 manter a homeostase.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;0px|0px|0px|0px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; make_equal=&#8221;on&#8221; admin_label=&#8221;CTA Row&#8221; module_class=&#8221; et_pb_row_fullwidth&#8221; _builder_version=&#8221;4.5.1&#8243; width=&#8221;100%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;&#8221; width_last_edited=&#8221;on|desktop&#8221; max_width=&#8221;100%&#8221; max_width_tablet=&#8221;100%&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px|0px|0px|0px&#8221; make_fullwidth=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/09\/anandamida.jpg&#8221; alt=&#8221;anandamida&#8221; title_text=&#8221;anandamida&#8221; force_fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.6.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_cta title=&#8221;Onde est\u00e3o os recetores canabin\u00f3ides presentes?&#8221; button_url=&#8221;#top&#8221; _builder_version=&#8221;4.6.1&#8243; header_font=&#8221;|800|||||||&#8221; header_text_color=&#8221;#ffffff&#8221; body_font=&#8221;Montserrat|500|||||||&#8221; body_text_color=&#8221;#ffffff&#8221; body_link_text_color=&#8221;#000000&#8243; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#2f3854&#8243; button_border_width=&#8221;10px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;60px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; button_alignment=&#8221;left&#8221; text_orientation=&#8221;left&#8221; max_width=&#8221;580px&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; module_alignment=&#8221;left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;40px|60px|2px|60px||&#8221; button_text_color_hover=&#8221;#2f3854&#8243; button_border_radius_hover=&#8221;66px&#8221; button_letter_spacing_hover=&#8221;1px&#8221; button_bg_color_hover=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;on&#8221; button_text_color__hover=&#8221;#2f3854&#8243; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;on&#8221; button_border_radius__hover=&#8221;66px&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;on&#8221; button_letter_spacing__hover=&#8221;1px&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;on&#8221; button_bg_color__hover=&#8221;#ffffff&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;]<\/p>\n<p><strong>CB1R<\/strong><\/p>\n<ul>\n<li>C\u00e9rebro<\/li>\n<li>Pulm\u00f5es<\/li>\n<li>Sistema vascular<\/li>\n<li>M\u00fasculos<\/li>\n<li>Trato Gastrointestinal<\/li>\n<li>\u00d3rg\u00e3os reprodutivos<\/li>\n<\/ul>\n<p><strong>CB2R<\/strong><\/p>\n<ul>\n<li>Ba\u00e7o<\/li>\n<li>Ossos<\/li>\n<li>Pele<\/li>\n<\/ul>\n<p><strong>CB1R e CB2R<\/strong><\/p>\n<ul>\n<li>Sistema imunit\u00e1rio<\/li>\n<li>F\u00edgado<\/li>\n<li>Medula \u00f3ssea<\/li>\n<li>P\u00e2ncreas<\/li>\n<\/ul>\n<p>Os endocanabin\u00f3ides podem ligar-se a qualquer um destes recetores e os seus efeitos depender\u00e3o do local onde o recetor est\u00e1 localizado e de qual canabin\u00f3ide se liga.<\/p>\n<p>Por exemplo, existem canabin\u00f3ides que visam recetores CB1 num nervo espinhal para aliviar a dor. Outros endocanabin\u00f3ides podem ligar-se com o recetor CB2 em c\u00e9lulas imunit\u00e1rias para fazer com que o corpo acredite que est\u00e1 a sofrer de inflama\u00e7\u00e3o, um sinal de defici\u00eancia imunit\u00e1ria.<\/p>\n<p>Os endocanabin\u00f3ides <strong>podem interagir n\u00e3o s\u00f3 com recetores canabin\u00f3ides, mas tamb\u00e9m com enzimas e canais de i\u00f5es.<\/strong> Por exemplo, <strong>a anandamida ativa e dessensibiliza um canal de i\u00f5es chamado TRPV1, reduzindo a perce\u00e7\u00e3o da dor.<\/strong><\/p>\n<p>[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;21px||18px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.5.1&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.5.1&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/09\/receptores-de-los-neurotransmisores.jpg&#8221; alt=&#8221;recetores neurotransmissor&#8221; title_text=&#8221;recetores neurotransmissor&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.6.1&#8243; background_enable_image=&#8221;off&#8221; background_size=&#8221;contain&#8221; max_width_phone=&#8221;300px&#8221; max_width_last_edited=&#8221;off|tablet&#8221; custom_margin=&#8221;|||-30%|false|false&#8221; custom_margin_tablet=&#8221;|||-15%|false|false&#8221; custom_margin_phone=&#8221;|||-10%|false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.4.4&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.6.1&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;off|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Como \u00e9 que os endocanabin\u00f3ides se avariam?<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Sua vida no corpo \u00e9 muito curta. Uma vez exercidas, s\u00e3o as enzimas respons\u00e1veis pela sua decomposi\u00e7\u00e3o:<\/p>\n<ul>\n<li>A hidrolasse que decomp\u00f5e a AEA<\/li>\n<li>O monoaciglycerol que decomp\u00f5e 2-AG<\/li>\n<\/ul>\n<p>Os n\u00edveis endocanabin\u00f3ides s\u00e3o determinados <strong>pelo equil\u00edbrio da<\/strong> s\u00edntese e desagrega\u00e7\u00e3o destes tratamentos de modo que a maioria dos tratamentos que procuram nivelar os endocanabin\u00f3ides no corpo atacam um destes dois processos.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;0px|0px|0px|0px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; make_equal=&#8221;on&#8221; admin_label=&#8221;CTA Row&#8221; module_class=&#8221; et_pb_row_fullwidth&#8221; _builder_version=&#8221;4.5.1&#8243; width=&#8221;100%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;&#8221; width_last_edited=&#8221;on|desktop&#8221; max_width=&#8221;100%&#8221; max_width_tablet=&#8221;100%&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px|0px|0px|0px&#8221; make_fullwidth=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/09\/hendidura-sinaptica.jpg&#8221; alt=&#8221;fenda sin\u00e1ptica&#8221; title_text=&#8221;fenda sin\u00e1ptica&#8221; force_fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.6.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_cta title=&#8221;Como manter a sa\u00fade do nosso sistema endocanabin\u00f3ide?&#8221; button_url=&#8221;#top&#8221; _builder_version=&#8221;4.6.6&#8243; header_font=&#8221;|800|||||||&#8221; header_text_color=&#8221;#ffffff&#8221; body_font=&#8221;Montserrat|500|||||||&#8221; body_text_color=&#8221;#ffffff&#8221; body_link_text_color=&#8221;#000000&#8243; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#2f3854&#8243; button_border_width=&#8221;10px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;60px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; button_alignment=&#8221;left&#8221; text_orientation=&#8221;left&#8221; max_width=&#8221;580px&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; module_alignment=&#8221;left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;40px|60px|2px|60px||&#8221; button_text_color_hover=&#8221;#2f3854&#8243; button_border_radius_hover=&#8221;66px&#8221; button_letter_spacing_hover=&#8221;1px&#8221; button_bg_color_hover=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;on&#8221; button_text_color__hover=&#8221;#2f3854&#8243; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;on&#8221; button_border_radius__hover=&#8221;66px&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;on&#8221; button_letter_spacing__hover=&#8221;1px&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;on&#8221; button_bg_color__hover=&#8221;#ffffff&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;]<\/p>\n<p>A falta de exerc\u00edcio, excesso de peso e stress podem afetar negativamente o equil\u00edbrio do nosso sistema endocanabin\u00f3ide e, portanto, <a href=\"https:\/\/higeacbd.com\/pt-pt\/datos\/homeostase\" title=\"Homeostasis CBD\">a homeostase<\/a> do nosso corpo. Para restaurar o equil\u00edbrio no nosso corpo podemos beneficiar de canabin\u00f3ides ex\u00f3genos, aqueles que n\u00e3o s\u00e3o produzidos pelo nosso corpo. Mais de 100 canabin\u00f3ides s\u00e3o encontrados apenas na planta da can\u00e1bis, embora a maioria esteja pendente de estudo cient\u00edfico. Os canabin\u00f3ides dos quais j\u00e1 sabemos um pouco mais gra\u00e7as \u00e0 ci\u00eancia s\u00e3o o CBD e o THC. CBD e THC interagem de forma diferente com recetores canabin\u00f3ides e \u00e9 por isso que o CBD carece de efeitos psicotr\u00f3picos. Em troca, o CBD liga-se a outros alvos moleculares, tais como recetores, enzimas e canais de i\u00f5es.<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;21px||18px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.5.1&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.5.1&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/02\/thc-receptores-cannabinoides.jpg&#8221; alt=&#8221;recetores thc canabin\u00f3ides&#8221; title_text=&#8221;Recetores canabin\u00f3ides THC&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.9.0&#8243; background_enable_image=&#8221;off&#8221; background_size=&#8221;contain&#8221; max_width_phone=&#8221;300px&#8221; max_width_last_edited=&#8221;off|tablet&#8221; custom_margin=&#8221;|||-30%|false|false&#8221; custom_margin_tablet=&#8221;|||-15%|false|false&#8221; custom_margin_phone=&#8221;|||-10%|false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.4.4&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;off|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Como \u00e9 que o THC interage com recetores canabin\u00f3ides?<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>ThC \u00e9 conhecido por ser um dos principais canabin\u00f3ides encontrados na can\u00e1bis. Quando o tetrahidrocanabinol (THC) entra no nosso corpo, <strong>interage diretamente com o sistema endocanabin\u00f3ide,<\/strong>porque une recetores canabin\u00f3ides, tal como os endocanabin\u00f3ides.<\/p>\n<p>O seu efeito potente deve-se, em parte, aos seus recetores de canabin\u00f3ides cb1 e cb2. Como resultado, o THC <strong>pode gerar uma grande variedade de efeitos no nosso corpo e<\/strong>mente, alguns n\u00e3o t\u00e3o desej\u00e1veis. Ou seja, enquanto, por um lado, pode ajudar-nos a reduzir a dor e a estimular o apetite, por outro pode causar ansiedade, e em alguns casos paranoia.<\/p>\n<p>Por isso, os cientistas est\u00e3o atualmente \u00e0 procura de formas de produzir canabin\u00f3ides sint\u00e9ticos de THC, que interagem com o sistema endocanabin\u00f3ide, mas apenas positivamente para a sa\u00fade.<\/p>\n<p>E enquanto o sistema endocanabin\u00f3ide desempenha um papel importante na manuten\u00e7\u00e3o dos processos internos do corpo est\u00e1veis, ainda falta muita pesquisa para uma melhor compreens\u00e3o das suas fun\u00e7\u00f5es e benef\u00edcios potenciais.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;21px||18px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.5.1&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.5.1&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cual-es-el-mejor-aceite-de-cbd.jpg&#8221; alt=&#8221;CBD e sistema endocanabin\u00f3ide&#8221; title_text=&#8221;CBD e sistema endocanabin\u00f3ide&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.6.1&#8243; background_enable_image=&#8221;off&#8221; background_size=&#8221;contain&#8221; max_width_phone=&#8221;300px&#8221; max_width_last_edited=&#8221;off|tablet&#8221; custom_margin=&#8221;|||-30%|false|false&#8221; custom_margin_tablet=&#8221;|||-15%|false|false&#8221; custom_margin_phone=&#8221;|||-10%|false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.4.4&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.6.1&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;off|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Como \u00e9 que o CBD afeta o nosso sistema endocanabin\u00f3ide?<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.6.1&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]O CBD aumenta os n\u00edveis de endocanabin\u00f3ide de anandamida inibindo a sua rece\u00e7\u00e3o e degrada\u00e7\u00e3o. Como resultado, h\u00e1 mais anandamida dispon\u00edvel para ativar recetores canabin\u00f3ides pr\u00e9-sin\u00e1pticos.<\/p>\n<p>Se quiser saber mais <a href=\"https:\/\/higeacbd.com\/pt-pt\/beneficios-do-cbd\" title=\"Benef\u00edcios da CDB\">sobre os benef\u00edcios do<\/a> consumo de CBD, recomendamos que leia o nosso artigo relacionado.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Art\u00edculos relacionados blog&#8221; _builder_version=&#8221;4.7.0&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;21px||9px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.5.1&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; custom_padding=&#8221;11px||7px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.7.0&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; header_4_font=&#8221;|800|||||||&#8221; header_4_text_align=&#8221;center&#8221; header_4_font_size=&#8221;45px&#8221; custom_margin=&#8221;||6px||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;off|desktop&#8221; header_4_font_size_tablet=&#8221;40px&#8221; header_4_font_size_phone=&#8221;25px&#8221; header_4_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Itens relacionados<\/h4>\n<p>[\/et_pb_text][et_pb_blog fullwidth=&#8221;off&#8221; posts_number=&#8221;6&#8243; include_categories=&#8221;current&#8221; show_more=&#8221;on&#8221; show_author=&#8221;off&#8221; show_date=&#8221;off&#8221; _builder_version=&#8221;4.7.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blog][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Subscribe&#8221; _builder_version=&#8221;4.5.1&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#f3f3f1&#8243; background_color_gradient_end=&#8221;rgba(255,255,255,0)&#8221; background_color_gradient_end_position=&#8221;30%&#8221; background_color_gradient_overlays_image=&#8221;on&#8221; background_image=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/aceite-de-cannabis-cbd.jpg&#8221; custom_padding=&#8221;100px|0px|30vw|0px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_duration=&#8221;1250ms&#8221; animation_intensity_slide=&#8221;1%&#8221; saved_tabs=&#8221;all&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;3.25&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.5.1&#8243; text_font=&#8221;|500|||||||&#8221; text_text_color=&#8221;rgba(47,56,84,0.5)&#8221; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;|700|||||||&#8221; header_2_font_size=&#8221;50px&#8221; header_2_line_height=&#8221;1.3em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;700px&#8221; module_alignment=&#8221;center&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Subscreva a nossa newsletter<\/h2>\n<p>Inscreva-se e receba um desconto de 10% na sua compra.  <\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_2,1_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;19px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_signup mailchimp_list=&#8221;higeacbd|5b4d14cf0e&#8221; first_name_field=&#8221;off&#8221; last_name_field=&#8221;off&#8221; _builder_version=&#8221;4.5.1&#8243; header_font=&#8221;||||||||&#8221; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#00a88d&#8221; button_border_width=&#8221;10px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;89px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; border_radii_fields=&#8221;on|30px|30px|30px|30px&#8221; 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button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;off&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;][\/et_pb_signup][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Footer&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; background_image=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cannabis-medicinal.jpg&#8221; background_size=&#8221;contain&#8221; background_position=&#8221;bottom_center&#8221; global_module=&#8221;452&#8243; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.5.1&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#000000&#8243; custom_padding=&#8221;4%|5%|4%|4%|true|false&#8221; custom_padding_tablet=&#8221;50px|30px|50px|30px|true|true&#8221; custom_padding_phone=&#8221;30px|20px|30px|20px|true|true&#8221; custom_padding_last_edited=&#8221;off|desktop&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.5.1&#8243; text_font=&#8221;Montserrat|800|||||||&#8221; text_font_size=&#8221;30px&#8221; text_line_height=&#8221;1.2em&#8221; link_text_color=&#8221;#000000&#8243; header_3_font=&#8221;|700||on|||||&#8221; header_3_text_color=&#8221;#96bf00&#8243; header_3_font_size=&#8221;16px&#8221; header_3_letter_spacing=&#8221;2px&#8221; header_3_line_height=&#8221;1.8em&#8221; header_4_font=&#8221;|700||on|||||&#8221; header_4_text_color=&#8221;#00a88d&#8221; header_4_font_size=&#8221;14px&#8221; header_4_letter_spacing=&#8221;2px&#8221; header_4_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;10px||10px||true|false&#8221; text_font_size_tablet=&#8221;22px&#8221; text_font_size_phone=&#8221;16px&#8221; text_font_size_last_edited=&#8221;on|desktop&#8221; header_3_font_size_tablet=&#8221;14px&#8221; header_3_font_size_phone=&#8221;12px&#8221; header_3_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Loja<\/h4>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png&#8221; alt=&#8221;s\u00edmbolo do higea&#8221; title_text=&#8221;s\u00edmbolo do higea&#8221; _builder_version=&#8221;4.5.1&#8243; custom_margin_tablet=&#8221;0px||||false|false&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_blurb use_icon=&#8221;on&#8221; 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header_4_font=&#8221;|700|||||||&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;10px||10px||true|false&#8221; text_font_size_tablet=&#8221;22px&#8221; text_font_size_phone=&#8221;16px&#8221; text_font_size_last_edited=&#8221;on|desktop&#8221; header_3_font_size_tablet=&#8221;14px&#8221; header_3_font_size_phone=&#8221;12px&#8221; header_3_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Aviso legal e pol\u00edtica de privacidade<\/h4>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png&#8221; alt=&#8221;s\u00edmbolo do higea&#8221; title_text=&#8221;s\u00edmbolo do higea&#8221; _builder_version=&#8221;4.5.1&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_blurb url_new_window=&#8221;on&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#000000&#8243; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.13.0&#8243; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; body_font=&#8221;|700||on|||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_letter_spacing=&#8221;2px&#8221; body_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; link_option_url_new_window=&#8221;on&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; body_font_size_tablet=&#8221;14px&#8221; body_font_size_phone=&#8221;12px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/higeacbd.com\/pt-pt\/isencao-de-responsabilidade-e-condicoes-gerais\" target=\"_blank\" rel=\"noopener nofollow\">AVISO LEGAL<\/a><\/p>\n<p>[\/et_pb_blurb][et_pb_blurb url_new_window=&#8221;on&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#000000&#8243; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.13.0&#8243; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; body_font=&#8221;|700||on|||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_letter_spacing=&#8221;2px&#8221; body_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; link_option_url_new_window=&#8221;on&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; body_font_size_tablet=&#8221;14px&#8221; body_font_size_phone=&#8221;12px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"https:\/\/higeacbd.com\/pt-pt\/politica-de-privacidade-e-aviso-de-cookies\" target=\"_blank\" rel=\"noopener nofollow\">PRIVACIDADE E COOKIES<\/a>[\/et_pb_blurb][et_pb_blurb url_new_window=&#8221;on&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#000000&#8243; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.13.0&#8243; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; body_font=&#8221;|700||on|||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_letter_spacing=&#8221;2px&#8221; body_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; link_option_url_new_window=&#8221;on&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; body_font_size_tablet=&#8221;14px&#8221; body_font_size_phone=&#8221;12px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/higeacbd.com\/pt-pt\/politica-de-devolucoes\" target=\"_blank\" rel=\"noopener nofollow\">POL\u00cdTICA DE DEVOLU\u00c7\u00c3O<\/a><\/p>\n<p>[\/et_pb_blurb][et_pb_blurb url_new_window=&#8221;on&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#000000&#8243; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.13.0&#8243; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; body_font=&#8221;|700||on|||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_letter_spacing=&#8221;2px&#8221; body_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; link_option_url_new_window=&#8221;on&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; body_font_size_tablet=&#8221;14px&#8221; body_font_size_phone=&#8221;12px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"https:\/\/higeacbd.com\/pt-pt\/contacto\" target=\"_blank\" rel=\"noopener nofollow\">contato<\/a>[\/et_pb_blurb][et_pb_text _builder_version=&#8221;4.6.5&#8243; 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url=&#8221;https:\/\/www.pinterest.es\/higeacbd\/&#8221; _builder_version=&#8221;4.6.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#cb2027&#8243; global_colors_info=&#8221;{}&#8221; follow_button=&#8221;off&#8221; url_new_window=&#8221;on&#8221;]pinterest[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=&#8221;twitter&#8221; url=&#8221;https:\/\/twitter.com\/higeacbd&#8221; _builder_version=&#8221;4.6.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#00aced&#8221; global_colors_info=&#8221;{}&#8221; follow_button=&#8221;off&#8221; url_new_window=&#8221;on&#8221;]twitter[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n<span class=\"et_bloom_bottom_trigger\"><\/span>","protected":false},"excerpt":{"rendered":"<p>O sistema endocanabin\u00f3ide est\u00e1 no nosso corpo e \u00e9 um conjunto de recetores que se encaixam com can\u00e1bis. 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