[et_pb_section fb_built=”1″ admin_label=”Anuncio superior” _builder_version=”4.9.4″ z_index=”999″ custom_margin=”0px||0px||true|false” custom_padding=”0px||0px||true|false” animation_direction=”top” custom_css_main_element=”position: relative;” global_module=”33910″ custom_css_main_element_last_edited=”on|desktop” custom_css_main_element_tablet=”position: relative;”][et_pb_row use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.9.0″ background_color=”#20a082″ background_color_gradient_direction=”90deg” width=”100%” max_width=”100%” custom_margin=”0px||0px||true|false” custom_padding=”0px||0px||true|false”][et_pb_column type=”4_4″ _builder_version=”4.0.6″ custom_css_main_element=”display:flex;||align-items: center;||justify-content: center;”][et_pb_blurb title=”Envio gratuito em Espanha e Portugal!” use_icon=”on” font_icon=”%%379%%” icon_color=”#FFFFFF” icon_placement=”left” use_icon_font_size=”on” icon_font_size=”16px” _builder_version=”4.9.0″ header_text_color=”#ffffff” header_font_size=”16px” header_line_height=”1.3em” max_width_tablet=”” max_width_phone=”230px” max_width_last_edited=”on|phone” custom_padding=”10px||||false|false” animation_direction=”left” header_font_size_tablet=”” header_font_size_phone=”14px” header_font_size_last_edited=”on|phone” icon_font_size__hover_enabled=”off|desktop”][\/et_pb_blurb][et_pb_button button_url=”https:\/\/higeacbd.com\/tienda” button_text=”Comprar CBD” _builder_version=”4.9.0″ custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#0b5b44″ button_bg_color_gradient_start=”#ff4ac2″ button_bg_color_gradient_end=”#ff4a9e” button_bg_color_gradient_direction=”90deg” button_border_width=”0px” button_border_radius=”20px” button_font=”|600|||||||” button_icon=”%%242%%” custom_margin=”|||20px|false|false” custom_margin_tablet=”” custom_margin_phone=”|||10px|false|false” custom_margin_last_edited=”on|desktop” custom_padding=”0px||0px||false|false” custom_padding_tablet=”” custom_padding_phone=”2px|8px|2px|8px|true|true” custom_padding_last_edited=”on|desktop” button_text_size_tablet=”” button_text_size_phone=”13px” button_text_size_last_edited=”on|phone”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Hero” _builder_version=”4.5.1″ background_color=”rgba(255,255,255,0.65)” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/marihuana-cbd.jpg” background_blend=”soft-light” custom_padding=”3vw||1vw|||”][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”O que s\u00e3o citocinas” _builder_version=”4.5.1″ header_level=”h1″ header_font=”|800|||||||” header_font_size=”45px” header_line_height=”1.3em” body_font=”|800|||||||” body_text_color=”#000000″ body_font_size=”20px” body_line_height=”1.6em” use_background_color=”off” custom_button=”on” button_text_size=”14px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_width=”8px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” background_layout=”light” animation_direction=”bottom” header_font_size_tablet=”” header_font_size_phone=”50px” header_font_size_last_edited=”on|phone” button_text_color_hover=”#ffffff” button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”rgba(47,56,84,0.9)” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”rgba(47,56,84,0.9)” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n
Explicamos o que s\u00e3o citocinas<\/strong> e as suas fun\u00e7\u00f5es.<\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Products” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”20px||11px||false|false”][et_pb_row _builder_version=”4.5.1″ custom_padding=”8px||17px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.6″ text_font=”|500|||||||” text_text_color=”#000000″ quote_font=”||||||||” header_font=”||||||||” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.4em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||12px|||”]<\/p>\n Citocinas ou citocinas<\/strong> s\u00e3o pequenas prote\u00ednas que fazem com que as c\u00e9lulas se comuniquem entre si, desencadeando diferentes respostas dependendo do que o corpo precisa.<\/p>\n Estas prote\u00ednas fazem parte do sistema imunit\u00e1rio inato e s\u00e3o respons\u00e1veis pela media\u00e7\u00e3o entre as c\u00e9lulas que o comp\u00f5em como linf\u00f3ides, inflamat\u00f3rios e hematopoi\u00e9ticos.<\/p>\n A comunica\u00e7\u00e3o intercelular ocorre ligando citocinas a recetores espec\u00edficos presentes na membrana celular, ativando certos genes que gerar\u00e3o uma resposta biol\u00f3gica espec\u00edfica.<\/p>\n Mais simplesmente, quando um elemento antig\u00e9nio como bact\u00e9rias, v\u00edrus ou c\u00e9lulas tumorais entram no corpo, as c\u00e9lulas ativam e atacam esses elementos para tentar destru\u00ed-los.<\/p>\n Se n\u00e3o for poss\u00edvel, v\u00e3o “chamar” outras c\u00e9lulas para as ajudar e atacar o agente que causa o mal.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_column type=”1_4″ _builder_version=”4.5.1″ 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custom_margin=”0em|0em|0.6em|0em|false|false” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwNSJ9fQ==@”][\/et_pb_wc_rating][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”2px||10px|||”]<\/p>\n Higea CBD 5% \u00f3leo ajuda a recuperar rapidamente dos seus treinos desportivos<\/p>\n [\/et_pb_text][et_pb_wc_add_to_cart product=”205″ show_quantity=”off” _builder_version=”4.5.1″ _module_preset=”default” custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_color=”#00a88d” button_border_radius=”0px” button_icon=”%%114%%”][\/et_pb_wc_add_to_cart][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_wc_images product=”207″ _builder_version=”4.5.1″ 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link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwNyJ9fQ==@”][\/et_pb_wc_rating][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”2px||10px|||”]<\/p>\n Higea CBD a 10% \u00e9 recomendado para tomar antes de dormir ou reduzir situa\u00e7\u00f5es de stress<\/p>\n [\/et_pb_text][et_pb_wc_add_to_cart product=”207″ show_quantity=”off” _builder_version=”4.5.1″ _module_preset=”default” custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_color=”#00a88d” button_border_radius=”0px” button_icon=”%%114%%”][\/et_pb_wc_add_to_cart][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default” 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link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwOCJ9fQ==@”][\/et_pb_wc_rating][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”2px||10px|||”]<\/p>\n Higea CBD 20% \u00e9 indicado para pessoas com problemas de ansiedade e doen\u00e7as em curso<\/p>\n [\/et_pb_text][et_pb_wc_add_to_cart product=”208″ show_quantity=”off” _builder_version=”4.5.1″ _module_preset=”default” custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_color=”#00a88d” button_border_radius=”0px” button_icon=”%%114%%”][\/et_pb_wc_add_to_cart][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_wc_images product=”211″ _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_wc_title product=”211″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” custom_margin=”||9px|||” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIxMSJ9fQ==@” border_color_all=”#00a88d” border_width_bottom=”2px” border_color_bottom=”#00205c”][\/et_pb_wc_title][et_pb_wc_price product=”211″ _builder_version=”4.5.1″ _module_preset=”default” body_font_size=”16px” custom_margin=”||10px|||”][\/et_pb_wc_price][et_pb_wc_rating product=”211″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” body_font_size=”10px” custom_margin=”0em|0em|0.6em|0em|false|false” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIxMSJ9fQ==@”][\/et_pb_wc_rating][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”2px||10px|||”]<\/p>\n Higea CBD 30% \u00e9 eficaz para pessoas com doen\u00e7as cr\u00f3nicas, dores severas. \u00c9 antiem\u00e9tico.<\/p>\n [\/et_pb_text][et_pb_wc_add_to_cart product=”211″ show_quantity=”off” _builder_version=”4.5.1″ _module_preset=”default” custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_color=”#00a88d” button_border_radius=”0px” button_icon=”%%114%%”][\/et_pb_wc_add_to_cart][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.5.1″ custom_padding=”8px||17px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.6″ text_font=”|500|||||||” text_text_color=”#000000″ quote_font=”||||||||” header_font=”||||||||” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.4em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||12px|||”]<\/p>\n Dependendo do tipo de citocinas e com as c\u00e9lulas com as quais interage, a mensagem ser\u00e1 diferente.<\/strong><\/p>\n Podem emitir sinais a outra c\u00e9lula imunit\u00e1ria para aumentar ou diminuir a sua produ\u00e7\u00e3o enzim\u00e1tica ou aumentar as suas fun\u00e7\u00f5es de efeito e combater a doen\u00e7a.<\/p>\n Tamb\u00e9m pode instruir uma c\u00e9lula para parar de trabalhar e morrer.<\/p>\n As citocinas s\u00e3o segregadas por linf\u00f3citos B e T (linf\u00f3citos ou linf\u00ednas), macr\u00f3fagos (monocinas) e granulocytes neutr\u00f3filos, entre outras c\u00e9lulas que tamb\u00e9m est\u00e3o envolvidas em p\u00f4r o sistema imunit\u00e1rio a funcionar.<\/p>\n Esta segrega\u00e7\u00e3o ocorre momentaneamente e est\u00e1 sujeita a um curto per\u00edodo de tempo.<\/p>\n Existem diferentes tipos de citocinas com m\u00faltiplas fun\u00e7\u00f5es biol\u00f3gicas. Alguns podem ter a mesma estrutura, mas com fun\u00e7\u00f5es diferentes ou simplesmente t\u00eam a capacidade de usar diferentes recetores.<\/p>\n Na verdade, a mesma citocina pode ter uma fun\u00e7\u00e3o espec\u00edfica sobre uma determinada c\u00e9lula, e ter outra fun\u00e7\u00e3o que \u00e9 completamente contr\u00e1ria a outra.<\/p>\n Devido \u00e0 sua complexidade, as citocinas podem ser divididas em v\u00e1rios grupos dependendo da sua estrutura, recetores ou funcionalidade. Ligam-se a terpenos,<\/a> flavonoides<\/a> e CBD para criar o chamado efeito de comitiva.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px”][et_pb_row _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”28px|40px|18px|40px||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n Quanto \u00e0 resposta inflamat\u00f3ria, as citocinas podem agir de duas formas totalmente opostas.<\/strong><\/p>\n Por um lado, favorecendo o desenvolvimento da referida resposta inflamat\u00f3ria, as chamadas citocinas pr\u00f3-inflamat\u00f3rias,<\/strong>e por outro, eliminando a inflama\u00e7\u00e3o, citocinas imunossupressoras.<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”40px||40px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.4.4″ custom_padding=”||18px|||” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.4.4″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/citocinas.jpg” alt=”Citocinas” title_text=”Citoquinas” _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n S\u00e3o ativados quando as c\u00e9lulas envolvidas na resposta imunol\u00f3gica entram em contacto com um agente patog\u00e9nico.<\/p>\n O que fazem \u00e9 ativar uma resposta inflamat\u00f3ria nas c\u00e9lulas, bem o oposto das citocinas anti-inflamat\u00f3rias.<\/p>\n S\u00e3o principalmente segregados por mon\u00f3citos, macr\u00f3fagos e linf\u00f3citos.<\/strong><\/p>\n O mais importante s\u00e3o os seguintes:<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.4.4″ custom_padding=”||18px|||” locked=”off”][et_pb_column type=”1_2″ _builder_version=”4.4.4″][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.9.2″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n A sua principal fun\u00e7\u00e3o \u00e9 regular a resposta inflamat\u00f3ria.<\/p>\n Pertence ao grupo de prote\u00ednas relacionadas com a produ\u00e7\u00e3o de leuc\u00f3citos (gl\u00f3bulos brancos) e outras c\u00e9lulas do corpo.<\/p>\n Existem duas formas, alfa interleukin (IL-1 alfa) e beta interleukin (IL-1 beta). Ambos agem no mesmo recetor.<\/p>\n Os principais produtores de IL-1 s\u00e3o macr\u00f3fagos, embora tamb\u00e9m seja sintetizado por queratin\u00f3citos, microglia, c\u00e9lulas endoteliais, fibroblastos e c\u00e9lulas epiteliais.<\/p>\n Ocorrem em grandes quantidades quando o corpo sofre uma infe\u00e7\u00e3o ou ferimento.<\/p>\n Os seus efeitos pr\u00f3-inflamat\u00f3rios s\u00e3o o resultado da liberta\u00e7\u00e3o de histamina por c\u00e9lulas mastros, causando vasodilata\u00e7\u00e3o e inflama\u00e7\u00e3o da \u00e1rea afetada.<\/p>\n Outro efeito \u00e9 a febre, como resultado da liberta\u00e7\u00e3o de prostaglandinas. Tamb\u00e9m atua no sistema nervoso central, causando sono e anorexia<\/a> t\u00edpicas de processos infeciosos.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n S\u00e3o citocinas produzidas por mon\u00f3citos, macr\u00f3fagos, linf\u00f3citos T e B, c\u00e9lulas assassinas naturais (NK), fibroblastos e c\u00e9lulas de mastro.<\/p>\n TNF, juntamente com IL-1, est\u00e1 envolvido no aparecimento de febre, cachexia (estado associado \u00e0 perda de peso, anemia ou anorexia) e sono, sintomas que normalmente se manifestam numa imagem infeciosa.<\/p>\n O fator de necrose tumoral tem a capacidade de induzir a morte de alguns tipos de c\u00e9lulas tumorais, bem como o aumento da resposta imune antitumor.<\/p>\n Estas s\u00e3o, portanto, citocinas que mediam nos processos de inflama\u00e7\u00e3o e morte celular.<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.4.4″ custom_padding=”||18px|||” locked=”off”][et_pb_column type=”1_2″ _builder_version=”4.4.4″][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n S\u00e3o citocinas que o corpo fabrica para lidar com a presen\u00e7a de diferentes agentes patog\u00e9nicos.<\/p>\n S\u00e3o classificados em dois tipos:<\/p>\n IFN-alpha \u00e9 uma prote\u00edna produzida principalmente por macr\u00f3fagos e linf\u00f3citos B.<\/p>\n \u00c9 usado no tratamento de alguns cancros devido ao seu poder de aumentar a capacidade de certas c\u00e9lulas imunit\u00e1rias e atacar as c\u00e9lulas cancer\u00edgenas.<\/p>\n A IFN-beta \u00e9 produzida por fibroblastos e c\u00e9lulas epiteliais.<\/p>\n IFN-gama \u00e9 segregado por c\u00e9lulas T ativadas e c\u00e9lulas NK.<\/p>\n A sua produ\u00e7\u00e3o \u00e9 aumentada pela a\u00e7\u00e3o de outras citocinas que, por sua vez, aumentam os efeitos hemodin\u00e2micos adversos destas citocinas na s\u00e9psis e no choque s\u00e9pstico.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n S\u00e3o fatores de crescimento e as suas fun\u00e7\u00f5es est\u00e3o associadas \u00e0 inflama\u00e7\u00e3o e \u00e0 produ\u00e7\u00e3o de outras citocinas.<\/p>\n Existem tr\u00eas tipos de fatores CSF:<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.4.4″ custom_padding=”||18px|||” locked=”off”][et_pb_column type=”4_4″ _builder_version=”4.4.4″][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n S\u00e3o assim definidas para um grupo muito espec\u00edfico de citocinas, que estimulam a mobilidade das c\u00e9lulas do sistema imunit\u00e1rio para um alvo.<\/p>\n A quimioquina pertence \u00e0 classe de mol\u00e9culas chamadas quimioatrasiantes, capazes de atrair e direcionar outras c\u00e9lulas de um \u00f3rg\u00e3o para outro.<\/p>\n Existem v\u00e1rios tipos de quimioterapia, incluindo interleukins, interfer\u00f5es, fatores de necrose tumoral e fatores de crescimento.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px”][et_pb_row _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”46px|40px|15px|40px||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n Corresponde a um grupo de citocinas que inibem o crescimento celular e suprimem ou bloqueiam a secre\u00e7\u00e3o de outras citocinas.<\/p>\n Citocinas que fazem parte deste grupo:<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”29px|40px|12px|40px||”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”30px” z_index=”2″ background_layout=”dark” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”off|desktop” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n Tem um efeito anti-inflamat\u00f3rio, pois reduz a produ\u00e7\u00e3o dos diferentes mediadores inflamat\u00f3rios de macr\u00f3fagos e bloqueia a a\u00e7\u00e3o da CYTOkine IL-1.<\/p>\n Ao mesmo tempo, desenvolve uma resposta imune humor\u00edstica para promover a indu\u00e7\u00e3o de c\u00e9lulas T em c\u00e9lulas do tipo Th2.<\/p>\n Est\u00e1 relacionado com a prolifera\u00e7\u00e3o de linf\u00f3citos B, mast\u00f3citos e linf\u00f3citos T.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”30px” z_index=”2″ background_layout=”dark” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”off|desktop” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n \u00c9 a citocina anti-inflamat\u00f3ria mais importante na resposta imunit\u00e1ria, agindo que exerce atrav\u00e9s da inibi\u00e7\u00e3o de outras citocinas como TNF-alfa, IL-2, IL-3, IL-12 e GM-CSF, entre outros.<\/p>\n \u00c9 segregado proporcionalmente \u00e0 intensidade do est\u00edmulo inflamat\u00f3rio.<\/p>\n O IL-10 exerce a sua a\u00e7\u00e3o anti-inflamat\u00f3ria em mon\u00f3citos, macr\u00f3fagos, neutr\u00f3filos e c\u00e9lulas T.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”19px|40px|41px|40px||”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”30px” z_index=”2″ background_layout=”dark” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”off|desktop” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n IL-13 \u00e9 uma citocina produzida por c\u00e9lulas T. \u00c9 consistente com o IL-2 no regulamento da s\u00edntese IFN-gama.<\/p>\n Al\u00e9m disso, inibe, juntamente com il-4 e IL-10, a produ\u00e7\u00e3o de citocinas inflamat\u00f3rias.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”30px” z_index=”2″ background_layout=”dark” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”off|desktop” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n S\u00e3o de dois tipos: alfa e beta, e n\u00e3o t\u00eam semelhan\u00e7a estrutural ou funcional entre eles.<\/p>\n V\u00e1rios tipos de c\u00e9lulas tais como linf\u00f3citos, macr\u00f3fagos e c\u00e9lulas dendr\u00edticas sintetizam tGF-beta.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.5.1″ custom_margin=”|auto|-2px|auto||” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.5.1″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/citocinas-proinflamatorias-y-antiinflamatorias.jpg” alt=”Citocinas pr\u00f3-inflamat\u00f3rias e anti-inflamat\u00f3rias” title_text=”Citocinas pr\u00f3-inflamat\u00f3rias e anti-inflamat\u00f3rias” align=”center” _builder_version=”4.5.1″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”off|desktop”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.9.2″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n No que diz respeito \u00e0 resposta imunit\u00e1ria, as citocinas agem de forma inata,<\/strong>isto \u00e9, imediatamente e n\u00e3o especificamente, ou de forma adaptativa.<\/strong><\/p>\n Isto porque reconhecem o antig\u00e9nio e criam uma mem\u00f3ria imune que dura mesmo que<\/a> o agente patog\u00e9nico j\u00e1 tenha sido removido.<\/p>\n Este grupo inclui citocinas produzidas por mon\u00f3citos e macr\u00f3fagos ativados imediatamente ap\u00f3s o contacto com o agente patog\u00e9nico.<\/p>\n As principais citocinas que comp\u00f5em este grupo s\u00e3o os participantes IL-1, TNF-alfa, IL-6 e IFN-gama na resposta inflamat\u00f3ria, e o IL-10 que tem uma a\u00e7\u00e3o imunossupressora.<\/p>\n Al\u00e9m destas citocinas, a resposta imunit\u00e1ria inata tamb\u00e9m envolve outros como IL-12 e IL-18.<\/strong><\/p>\n A a\u00e7\u00e3o mais importante destas duas citocinas \u00e9 ser indutores potentes da IFN-gama:<\/strong><\/p>\n S\u00e3o essenciais para uma sequ\u00eancia de resposta envolvendo macr\u00f3fagos, linf\u00f3citos NK e c\u00e9lulas T.<\/p>\n O IL-12 aumenta o aparecimento de c\u00e9lulas T citot\u00f3xicas, que s\u00e3o um tipo de c\u00e9lulas imunit\u00e1rias que podem erradicar as c\u00e9lulas cancer\u00edgenas e as c\u00e9lulas infetadas pelo v\u00edrus.<\/p>\n Tem a mesma a\u00e7\u00e3o conjunta que o IL-12 no que diz respeito \u00e0 produ\u00e7\u00e3o de IFN-gama em c\u00e9lulas T e c\u00e9lulas assassinas naturais.<\/p>\n A Interleukin 18 aumenta a produ\u00e7\u00e3o il-2, participa no regulamento da resposta do tipo Th1 e pode diminuir a produ\u00e7\u00e3o il-10.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.5.1″ background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/que-enfermedades-cura-el-cbd.jpg” overflow-x=”hidden” overflow-y=”hidden” custom_padding=”0px||0px||true|false”][et_pb_row column_structure=”3_5,2_5″ make_equal=”on” _builder_version=”4.5.1″ width_tablet=”100%” width_phone=”” width_last_edited=”on|tablet” custom_padding=”0px||0px||true|false” box_shadow_style=”preset4″ box_shadow_horizontal=”-30vw” box_shadow_vertical=”0px” box_shadow_color=”#00a88d” box_shadow_horizontal_tablet=”0vw” box_shadow_horizontal_phone=”” box_shadow_horizontal_last_edited=”on|tablet”][et_pb_column type=”3_5″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”3vh|30px|3vh||true|false” custom_padding_tablet=”10%|10%|10%|10%|true|true” custom_padding_phone=”||||false|true” custom_padding_last_edited=”on|phone”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07.png” _builder_version=”4.4.4″ custom_margin=”50px||||false|false” custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off”][\/et_pb_image][et_pb_text _builder_version=”4.5.1″ header_font=”|800|||||||” header_font_size=”100px” header_line_height=”1.2em” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” background_layout=”dark” header_font_size_tablet=”40px” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_text_color=”#ffffff” link_text_color=”#000000″ background_layout=”dark” text_font_size_tablet=”14px” text_font_size_phone=”” text_font_size_last_edited=”on|phone”]<\/p>\n A ativa\u00e7\u00e3o dos linf\u00f3citos T e B requer a participa\u00e7\u00e3o de determinadas citocinas, tais como a interleucina 2 (IL-2), 15 (IL-15) e 16 (IL-16).<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.5.1″ custom_padding=”20%|0px|20%||true|false” custom_padding_tablet=”|10%||10%|false|true” custom_padding_phone=”||||false|false” custom_padding_last_edited=”on|phone”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”35px|40px|41px|40px||” box_shadow_style=”preset4″ box_shadow_horizontal=”-1044px” box_shadow_vertical=”0px” box_shadow_color=”#00a88d”][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_3_font=”Montserrat|800|||||||” header_3_font_size=”20px” header_3_line_height=”1.2em” text_orientation=”center” background_layout=”dark” header_3_font_size_tablet=”18px” header_3_font_size_phone=”16px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n Criado por linf\u00f3citos Th1, provoca o crescimento e diferencia\u00e7\u00e3o da resposta dos linf\u00f3citos T e B.<\/p>\n A interleuina IL-2 \u00e9 necess\u00e1ria para o estabelecimento da mem\u00f3ria imune celular e o reconhecimento de autoantigenos e antig\u00e9nios externos.<\/p>\n Desempenha um papel fundamental no desenvolvimento de respostas inflamat\u00f3rias cr\u00f3nicas humorais e celulares.<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_3_font=”Montserrat|800|||||||” header_3_font_size=”20px” header_3_line_height=”1.2em” text_orientation=”center” background_layout=”dark” header_3_font_size_tablet=”18px” header_3_font_size_phone=”16px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n Tem uma atividade biol\u00f3gica semelhante \u00e0 IL-2, embora diferissem nas c\u00e9lulas em que atuam.<\/p>\n O IL-15 \u00e9 segregado por uma grande variedade de c\u00e9lulas, incluindo mon\u00f3citos, c\u00e9lulas epiteliais, miocitos e hepatocytes.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_3_font=”Montserrat|800|||||||” header_3_font_size=”20px” header_3_line_height=”1.2em” text_orientation=”center” background_layout=”dark” header_3_font_size_tablet=”18px” header_3_font_size_phone=”16px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n A citocina IL-16 \u00e9 produzida por linf\u00f3citos CD8 T em resposta \u00e0 estimula\u00e7\u00e3o da serotonina ou da histamina.<\/p>\n Funciona como um atrativo qu\u00edmico e como um modulador da ativa\u00e7\u00e3o das c\u00e9lulas T.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”36px|0px|0px|0px||”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.5.1″][et_pb_column type=”1_2″ _builder_version=”4.5.1″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/citoquinas-proinflamatorias.jpg” alt=”Citocinas pr\u00f3-inflamat\u00f3rias” title_text=”Citocinas pr\u00f3-inflamat\u00f3rias” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.5.1″ animation_style=”slide” animation_direction=”right” animation_intensity_slide=”5%”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” text_font=”||||||||” text_font_size=”16px” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n \u00c9 criado principalmente por linf\u00f3citos th2 e interage na regula\u00e7\u00e3o da hematopoiese controlando a produ\u00e7\u00e3o, diferencia\u00e7\u00e3o e fun\u00e7\u00e3o de granuloc\u00edtos e macr\u00f3fagos.<\/p>\n Produzido por c\u00e9lulas T e c\u00e9lulas de mastro, estimula o crescimento e prolifera\u00e7\u00e3o de eosin\u00f3filos, desempenhando um papel muito importante nas doen\u00e7as associadas ao aumento dos seus n\u00edveis.<\/p>\n Segregados por mon\u00f3citos-macr\u00f3fagos ativados, linf\u00f3citos T e B ativados, c\u00e9lulas endoteliais e fibroblastos.<\/p>\n O IL-6 tem ambas as propriedades anti-inflamat\u00f3rias, uma vez que tem uma poderosa capacidade de induzir a liberta\u00e7\u00e3o de prote\u00ednas de fase aguda que t\u00eam um efeito ben\u00e9fico na s\u00e9psis e choque s\u00e9ptico, bem como pr\u00f3-inflamat\u00f3rio.<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”|0px|0px|0px||” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta button_url=”#top” _builder_version=”4.5.1″ header_level=”h3″ header_font=”|800|||||||” header_font_size=”22px” header_line_height=”1.4em” body_font=”|500|||||||” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” background_layout=”light” max_width=”80%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”right” custom_padding=”5%|10%|0px|10%|false|true” header_font_size_last_edited=”off|desktop” button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n Estimula o desenvolvimento de c\u00e9lulas precursoras de linf\u00f3citos B e T.<\/p>\n O IL-7 tem atividade antitumor, aumentando a produ\u00e7\u00e3o de c\u00e9lulas T citot\u00f3xicas e c\u00e9lulas NK.<\/p>\n Produzido por queratin\u00f3citos, c\u00e9lulas dendr\u00edticas, hepatocytes, neur\u00f3nios e c\u00e9lulas epiteliais.<\/p>\n \u00c9 criado por mon\u00f3citos, macr\u00f3fagos, fibroblastos, queratin\u00f3citos e c\u00e9lulas endoteliais.<\/p>\n A sua principal fun\u00e7\u00e3o \u00e9 atrair linf\u00f3citos virgens e neutr\u00f3filos, bem como mobilizar, ativar e causar a degranula\u00e7\u00e3o dos neutr\u00f3filos.<\/p>\n Estimula a angiog\u00e9nese e a forma\u00e7\u00e3o de novos vasos sangu\u00edneos dos pr\u00e9-existentes.<\/p>\n \u00c9 uma glicoprote\u00edna com capacidade mitog\u00e9nica e para induzir a prolifera\u00e7\u00e3o de c\u00e9lulas T.<\/p>\n \u00c9 produzido pelas c\u00e9lulas estroma da medula \u00f3ssea e pelas c\u00e9lulas mesenquim\u00e1ticas.<\/p>\n Atua em c\u00e9lulas hematopoi\u00e9ticas, c\u00e9lulas epiteliais intestinais e c\u00e9lulas hep\u00e1ticas.<\/p>\n No entanto, tem pouco efeito sobre os linf\u00f3citos.<\/strong><\/p>\n \u00c9 uma glicoprote\u00edna produzida por c\u00e9lulas CD4+ T estimuladas.<\/p>\n \u00c9 capaz de estimular a secre\u00e7\u00e3o de IL-6, IL-8 e G-CSF por c\u00e9lulas epiteliais, c\u00e9lulas endoteliais e fibroblastos.<\/p>\n [\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/citoquinas-alimentos.jpg” alt=”citocinas alimentares” title_text=”Citocinas alimentares” _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_color_gradient_direction=”90deg” background_enable_image=”off” background_position=”bottom_center” custom_padding=”0%||0%||true|false”][et_pb_row custom_padding_last_edited=”on|desktop” _builder_version=”4.5.1″ use_background_color_gradient=”on” background_color_gradient_start=”rgba(0,0,0,0.2)” background_color_gradient_end=”rgba(0,0,0,0.2)” background_color_gradient_overlays_image=”on” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cbd-medicinal.jpg” width=”100%” max_width=”none” custom_padding=”7%|5%|7%|5%|true|true” custom_padding_tablet=”5%|10%|5%|10%|true|true” custom_padding_phone=””][et_pb_column type=”4_4″ _builder_version=”4.4.4″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07.png” align=”center” _builder_version=”4.4.8″ locked=”off”][\/et_pb_image][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800||on|||||” text_font_size=”18px” text_letter_spacing=”2px” header_font=”|800|||||||” header_font_size=”100px” header_line_height=”1.2em” header_3_font=”|800||on|||||” header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|800|||||||” header_4_font_size=”100px” text_orientation=”center” background_layout=”dark” text_font_size_tablet=”18px” text_font_size_phone=”” text_font_size_last_edited=”on|phone” header_font_size_tablet=”40px” header_font_size_phone=”30px” header_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|desktop” header_4_font_size_tablet=”40px” header_4_font_size_phone=”30px” header_4_font_size_last_edited=”on|phone”]<\/p>\n Toda a informa\u00e7\u00e3o sobre citocinas e citocinas<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/tipos-de-interleucinas.jpg” alt=”tipos de interleukins” title_text=”Tipos de interleukins” force_fullwidth=”on” _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”Citocinas anti-inflamat\u00f3rias” button_url=”#top” _builder_version=”4.5.1″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n As citocinas anti-inflamat\u00f3rias mais importantes s\u00e3o consideradas IL-10, IL-4, IL-6, IL-13, FEC-GM e interferon alfa (IFN-alpha).<\/strong><\/p>\n T\u00eam a capacidade de inibir a liberta\u00e7\u00e3o de citocinas pr\u00f3-inflamat\u00f3rias e induzir a produ\u00e7\u00e3o do antagonista recetor IL-1 e a liberta\u00e7\u00e3o do recetor sol\u00favel da FNT.<\/p>\n Agora que sabes o que s\u00e3o citocinas, sabes melhor como funciona o mundo celular e, em \u00faltima an\u00e1lise, o corpo de qualquer um.<\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Subscribe” _builder_version=”4.9.4″ use_background_color_gradient=”on” background_color_gradient_start=”#f3f3f1″ background_color_gradient_end=”rgba(255,255,255,0)” background_color_gradient_end_position=”30%” background_color_gradient_overlays_image=”on” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/aceite-de-cannabis-cbd.jpg” custom_padding=”100px|0px|30vw|0px” animation_direction=”bottom” saved_tabs=”all”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ text_font=”|500|||||||” text_text_color=”rgba(47,56,84,0.5)” text_font_size=”16px” 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button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” border_radii_fields=”on|30px|30px|30px|30px” border_width_all_fields=”1px” border_color_all_fields=”rgba(47,56,84,0.2)” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_signup][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cannabis-medicinal.jpg” background_size=”contain” background_position=”bottom_center” global_module=”452″ saved_tabs=”all” locked=”off”][et_pb_row column_structure=”1_3,1_3,1_3″ make_equal=”on” _builder_version=”4.5.1″][et_pb_column type=”1_3″ _builder_version=”4.5.1″ background_color=”#000000″ custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#00a88d” header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”1.8em” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png” alt=”s\u00edmbolo do higea” title_text=”s\u00edmbolo do higea” _builder_version=”4.5.1″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off”][\/et_pb_image][et_pb_blurb use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop”]<\/p>\n 5% CDB<\/a><\/p>\n [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop”]10% CDB<\/a>[\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop”]<\/p>\nCitocinas envolvidas na resposta inflamat\u00f3ria<\/h2>\n
Citocinas pr\u00f3-inflamat\u00f3rias<\/h2>\n
Interleukin 1 (IL-1)<\/h3>\n
Fator de necrose tumoral (TNF)<\/h3>\n
Interfer\u00f5es (IFN)<\/h3>\n
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Fatores estimulantes da col\u00f3nia (CSF)<\/h3>\n
\n
Quimioterapia ou quimioterapia<\/h3>\n
Citocinas imunossupressoras<\/h2>\n
Interleukin 4 (IL-4)<\/h3>\n
Interleukin 10 (IL-10)<\/h3>\n
Interleukin 13 (IL-13)<\/h3>\n
Fator transformador de crescimento (TGF)<\/h3>\n
Citocinas envolvidas na resposta imune<\/h2>\n
Citocinas envolvidas na resposta imune inata<\/h2>\n
Interleukin 12 (IL-12)<\/h3>\n
Interleukin 18 (IL-18)<\/h3>\n
Citocinas envolvidas na resposta imune adaptativa<\/h2>\n
Interleukin 2 (IL-2)<\/h3>\n
Interleukin 15 (IL-15)<\/h3>\n
Interleukin 16 (IL-16)<\/h3>\n
Outros interleukins ou interleukins<\/h2>\n
Interleukin 3 (IL-3)<\/h3>\n
Interleukin 5 (IL-5)<\/h3>\n
Interleukin 6 (IL-6)<\/h3>\n
Interleukin 7 (IL-7)<\/h3>\n
Interleukin 8 (IL-8)<\/h3>\n
Interleukin 9 (IL-9)<\/h3>\n
Interleukin 11 (IL-11)<\/h3>\n
Interleukin 17 (IL-17)<\/h3>\n
Saiba o que est\u00e1 a consumir<\/h4>\n
Subscreva a nossa newsletter<\/h2>\n
Loja<\/h4>\n