[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Products” _builder_version=”4.16″ background_color=”#f3f3f1″ custom_padding=”20px||11px||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”8px||17px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.2″ text_font=”|500|||||||” text_text_color=”#000000″ quote_font=”||||||||” header_font=”||||||||” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.4em” text_orientation=”center” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||12px|||” global_colors_info=”{}”]<\/p>\n
Embora as pessoas com depress\u00e3o tenham usado antidepressivos h\u00e1 d\u00e9cadas, a ci\u00eancia n\u00e3o tinha realmente descoberto o seu funcionamento biol\u00f3gico, at\u00e9 agora. Um novo estudo p\u00f5e em causa tudo o que era conhecido anteriormente sobre a forma como os medicamentos antidepressivos funcionam.<\/strong><\/p>\n Esta nova pesquisa sugere que os inibidores seletivos de reabsor\u00e7\u00e3o de serotonina(SSRIs),que s\u00e3o f\u00e1rmacos de a\u00e7\u00e3o lenta no tratamento da depress\u00e3o, e cetaminade a\u00e7\u00e3o r\u00e1pida s\u00e3o diretamente combinados com um recetor de fator neurotr\u00f3fico derivado do c\u00e9rebro(BDNF). Como resultado, promovem a plasticidade neural, que por sua vez alivia a depress\u00e3o, mas sem o uso de Serotonina ou Glutamato.<\/p>\n Abaixo, discutimos as conclus\u00f5es deste novo estudo sobre o funcionamento dos antidepressivos. Falaremos tamb\u00e9m um pouco sobre a utiliza\u00e7\u00e3o do canabidiol CBD e das suas propriedades anti-depressivas.<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Produtos” _builder_version=”4.7.7″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_module=”16824″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_shop type=”best_selling” posts_number=”8″ show_pagination=”on” module_class=”custom-shop” _builder_version=”4.16″ _module_preset=”default” title_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][\/et_pb_shop][et_pb_signup mailchimp_list=”higeacbd|5b4d14cf0e” first_name_field=”off” last_name_field=”off” title=”Inscreva-se e receba um desconto de 10%” disabled_on=”off|off|off” _builder_version=”4.16″ header_level=”h4″ header_font=”|800|||||||” header_text_align=”center” header_text_color=”#000000″ header_font_size=”35px” header_line_height=”1.2em” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” button_custom_padding=”18px|0px|18px|0px|true|true” button_custom_padding_tablet=”14px||14px||true|true” button_custom_padding_phone=”12px||12px||true|true” button_custom_padding_last_edited=”on|phone” background_layout=”light” header_font_size_tablet=”25px” header_font_size_phone=”20px” header_font_size_last_edited=”on|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style_button=”preset4″ box_shadow_horizontal_button=”0px” box_shadow_vertical_button=”2px” box_shadow_color_button=”#00a88d” global_colors_info=”{}” button_text_color__hover=”#28221d” button_text_color__hover_enabled=”on|hover” box_shadow_color_button__hover=”#000000″ box_shadow_color_button__hover_enabled=”on|desktop”][\/et_pb_signup][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”28px|40px|18px|40px||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.4″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” hover_enabled=”0″ header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n A investiga\u00e7\u00e3o de que estamos a falar \u00e9 um estudo internacional<\/a> publicado na revista Cell,<\/a>liderado por dois neurocientistas de nomes Eero Castr\u00e9n<\/strong> e Plino Cassaroto.<\/strong> Realizou-se no Centro de Neuroci\u00eancias da Universidade de Hels\u00ednquia em colabora\u00e7\u00e3o com o Departamento de F\u00edsica.<\/p>\n O objetivo da pesquisa era determinar como os antidepressivos interagem com um recetor BDNF conhecido como TrkB.<\/strong> Especificamente, foram estudados os seguintes f\u00e1rmacos:<\/p>\n Inicialmente, pensava-se que os efeitos das SSREs e os efeitos dos antidepressivos tric\u00edclicos,<\/strong>originaram-se na sua pr\u00f3pria capacidade de reter mais serotonina e norepinefrina no c\u00e9rebro, aumentando os seus n\u00edveis no fosso sin\u00e1ptico. Tamb\u00e9m se pensava que o efeito antidepressivo da cetamina se destinava a inibir os recetores de glutamato.<\/p>\n Estes tr\u00eas antidepressivos analisados na pesquisa<\/strong> mostraram-se a interagir com o recetor TrkB.<\/strong> No entanto, fizeram-no sem aumentar ou inibir outros neurotransmissores como serotonina, norepinefrina ou glutamato.<\/p>\n Note-se que outras pesquisas j\u00e1 tinham identificado a rela\u00e7\u00e3o entre antidepressivos que aumentam os fatores neurotr\u00f3ficos. \u00c9 o caso da BDNF (Brain Derived Neurotrophic Fator), que desempenha um papel crucial na regula\u00e7\u00e3o da neuroplasticidade.<\/strong><\/p>\n No entanto, os investigadores pensaram que os medicamentos antidepressivos atuavam indiretamente no BDNF atrav\u00e9s de recetores de glutamato e serotonina. Os resultados desta pesquisa t\u00eam o potencial de ser revolucion\u00e1rios, revelando que os antidepressivos realmente se juntam diretamente aos recetores de BDNF.<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.16″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”40px||40px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ custom_padding=”||18px|||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/como-funcionan-los-antidepresivos.jpg” alt=”como os antidepressivos funcionam” title_text=”como os antidepressivos funcionam” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.19.4″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n Durante duas d\u00e9cadas, os cientistas sabem que as drogas antidepressivas e o exerc\u00edcio aer\u00f3bico promovem a plasticidade neuronal e o crescimento de novos neur\u00f3nios. Existe tamb\u00e9m uma investiga\u00e7\u00e3o sobre exerc\u00edcio e desordem depressiva,<\/a>onde a correla\u00e7\u00e3o entre o BDNF induzido pelo exerc\u00edcio aumentado e um menor risco de grandes perturba\u00e7\u00f5es depressivas foi investigado.<\/strong><\/p>\n Al\u00e9m disso, outras investiga\u00e7\u00f5es focaram-se em determinar como a efic\u00e1cia dos antidepressivos pode estar relacionada com a BDNF. Os investigadores tamb\u00e9m determinaram como uma via molecular relacionada com a prote\u00edna ativadora 1 facilita uma rea\u00e7\u00e3o em cadeia que ativa v\u00e1rios genes, que por sua vez promovem a plasticidade neural.<\/p>\n Isto permite ao c\u00e9rebro reverter danos neurol\u00f3gicos que est\u00e3o geralmente relacionados com a depress\u00e3o. Algo interessante sobre isso \u00e9 que ap\u00f3s duas ou tr\u00eas semanas, os efeitos regenerativos de tais mudan\u00e7as podem ser vistos e sentidos.<\/strong> Estudos a este respeito ajudaram a explicar por que raz\u00e3o as 10REs demoram at\u00e9 14 dias a ser ativadas.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”46px|40px|41px|40px||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n Pesquisas anteriores mostraram que num tratamento terap\u00eautico com drogas seletivas de inibidor de reabsor\u00e7\u00e3o de serotonina (SSRS), os antidepressivos gradualmente atingem uma alta concentra\u00e7\u00e3o cerebral para se ligarem ao recetor TrkB.<\/strong> Em contraste, a cetamina e a sketamina, administradas intravenosamente, atingem o n\u00edvel necess\u00e1rio para se ligarem a Trkb em poucos minutos.<\/p>\n De acordo com os investigadores, a diferen\u00e7a no in\u00edcio da a\u00e7\u00e3o de SSRS e cetamina pode ser o resultado da sua diferente capacidade de alcan\u00e7ar no c\u00e9rebro, a concentra\u00e7\u00e3o necess\u00e1ria para se ligar ao recetor TrkB. Tamb\u00e9m se deve dizer que a cetamina era geralmente usada como anest\u00e9sico, mas agora \u00e9 cada vez mais usada como um antidepressivo.<\/p>\n Embora os f\u00e1rmacos SSRS se liguem \u00e0 prote\u00edna de transporte de serotonina muito mais gananciosamente do que a TrkB, a liga\u00e7\u00e3o da cetamina ao recetor de glutamato e ao TrkB ocorre em concentra\u00e7\u00f5es semelhantes de drogas.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.16″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ custom_margin=”|auto|-2px|auto||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/colesterol-y-antidepresivos.jpg” alt=”colesterol e antidepressivos” title_text=”colesterol e antidepressivos” align=”center” _builder_version=”4.16″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n A localiza\u00e7\u00e3o exata da liga\u00e7\u00e3o dos antidepressivos na regi\u00e3o transmembrana de TrkB foi identificada atrav\u00e9s da modela\u00e7\u00e3o molecular. Este modelo foi realizado por um grupo de investigadores do Departamento de F\u00edsica da Universidade de Hels\u00ednquia, liderado pelo Professor Ilpo Vattuainen. Para verificar o local, os cientistas realizaram estudos da jun\u00e7\u00e3o bioqu\u00edmica e das muta\u00e7\u00f5es introduzidas no recetor TrkB.<\/p>\n Outro aspeto relevante que a modela\u00e7\u00e3o molecular demonstrou \u00e9 que a estrutura do TrkB, \u00e9 sens\u00edvel \u00e0 concentra\u00e7\u00e3o de colesterol na membrana celular.<\/strong> Isto \u00e9 importante porque o TrkB se move em compartimentos de membrana, que s\u00e3o conhecidos por serem uma rica fonte de colesterol, como membranas sin\u00e1pticas. A liga\u00e7\u00e3o do TrkB com o f\u00e1rmaco antidepressivo estabiliza os esmerifos, que s\u00e3o estruturas compostas por dois recetores TrkB.<\/p>\n Quando isso acontece, a desloca\u00e7\u00e3o dos recetores TrkB \u00e9 inibida, enquanto aumenta a sua quantidade em membranas sin\u00e1pticas de c\u00e9lulas. Como resultado, os efeitos do BDNF s\u00e3o melhorados. Por outras palavras, os medicamentos antidepressivos n\u00e3o ativam diretamente o TrkB.<\/strong> O que realmente fazem \u00e9 sensibilizar o destinat\u00e1rio para os efeitos da BDNF.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”46px|40px|41px|40px||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n Tudo isto \u00e9 importante porque h\u00e1 evid\u00eancias de que as pessoas com tend\u00eancias suicidas ou que se suicidaram t\u00eam baixos n\u00edveis de colesterol.<\/strong> O problema \u00e9 que estabelecer uma rela\u00e7\u00e3o direta com isto \u00e9 complicado. Especialmente porque o c\u00e9rebro usa principalmente o colesterol que produz.<\/p>\n Al\u00e9m disso, pode haver um conflito com as estatinas, que s\u00e3o medicamentos consumidos por milh\u00f5es de pessoas em todo o mundo. Estas drogas s\u00e3o usadas para controlar os n\u00edveis de colesterol no sangue. Na verdade, os investigadores perguntaram-se se as estatinas estavam a bloquear o efeito antidepressivo.<\/strong><\/p>\n A pesquisa tamb\u00e9m serviu para mostrar que quando uma alta dose de estatinas \u00e9 injetada, com o objetivo de reduzir os n\u00edveis de colesterol no c\u00e9rebro, os antidepressivos j\u00e1 n\u00e3o aumentam a neuroplasticidade. Os investigadores analisaram ent\u00e3o estudos humanos em que isso n\u00e3o acontece porque as estatinas n\u00e3o chegam ao c\u00e9rebro.<\/p>\n Ou seja, com as doses de estatina geralmente utilizadas em humanos, estas drogas n\u00e3o geram problemas. Quanto aos n\u00edveis de colesterol no sangue, os cientistas concordam que \u00e9 necess\u00e1ria mais investiga\u00e7\u00e3o para que encontrem algum tipo de liga\u00e7\u00e3o.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.16″ background_color=”#f3f3f1″ custom_padding=”36px|0px|0px|0px||” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/cbd-antidepresivo.jpg” alt=”antidepressivo cbd” title_text=”antidepressivo cbd” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ animation_style=”slide” animation_direction=”right” animation_intensity_slide=”5%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”||||||||” text_font_size=”16px” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Agora que os investigadores j\u00e1 sabem que a plasticidade cerebral \u00e9 fundamental na a\u00e7\u00e3o dos antidepressivos, a quest\u00e3o que se coloca \u00e9 porque \u00e9 que os antidepressivos funcionam mais depressa do que outros? Os cientistas sabem que muitos antidepressivos convencionais,<\/strong>como o Escitalopram, ou Fluoxetina, requerem semanas para come\u00e7ar a produzir efeito a um n\u00edvel psicologicamente vis\u00edvel.<\/p>\n Pelo contr\u00e1rio, existem outros medicamentos antidepressivos que agem muito mais rapidamente, como a cetamina acima mencionada. Tudo parece indicar que \u00e9 um assunto relacionado com o tempo que leva para chegar a estas drogas nas concentra\u00e7\u00f5es necess\u00e1rias no c\u00e9rebro.<\/strong> \u00c9 por isso que demoram v\u00e1rios dias, e tamb\u00e9m porque n\u00e3o conseguem parar de consumir.<\/p>\n No caso de drogas de a\u00e7\u00e3o r\u00e1pida, podem penetrar mais facilmente na barreira cerebral do sangue, at\u00e9 que finalmente obtenham a concentra\u00e7\u00e3o necess\u00e1ria para ativar o recetor TrkB.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/investigacion-antidepresivos.jpg” alt=”investiga\u00e7\u00e3o antidepressiva” title_text=”investiga\u00e7\u00e3o antidepressiva” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ animation_style=”slide” animation_direction=”right” animation_intensity_slide=”5%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”||||||||” text_font_size=”16px” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.16″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ custom_margin=”|auto|-2px|auto||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/antidepresivos-cbd-corto-plazo.jpg” alt=”antidepressivos de curto prazo cbd” title_text=”antidepressivos de curto prazo cbd” align=”center” _builder_version=”4.16″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n Os resultados revelaram que o CBD canabidiol induziu um efeito antidepressivo em ratos de forma dependente de dose. Este mesmo teste tamb\u00e9m foi realizado em ratos, e os resultados obtidos foram semelhantes aos dos ratos. Os investigadores tamb\u00e9m descobriram que todos estes efeitos antidepressivos agudos, avaliados<\/strong>ap\u00f3s o teste de nata\u00e7\u00e3o 30 minutos ap\u00f3s o tratamento, estavam relacionados com a capacidade do canabidiol de aumentar os n\u00edveis de BDNF.<\/strong><\/p>\n Este aumento nos n\u00edveis de BDNF foi apresentado tanto no hipocampo como no c\u00f3rtex pr\u00e9-frontal dos roedores. Isto \u00e9 importante uma vez que o fator neurotr\u00f3fico derivado do c\u00e9rebro (BDNF) \u00e9 um fator crucial para o crescimento dos neur\u00f3nios. Al\u00e9m disso, os investigadores tamb\u00e9m descobriram que os marcadores da plasticidade sin\u00e1ptica,<\/strong>que s\u00e3o indispens\u00e1veis para a remodela\u00e7\u00e3o cerebral, tamb\u00e9m sofreram um aumento no c\u00f3rtex pr\u00e9-frontal do c\u00e9rebro.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.16″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ custom_margin=”|auto|-2px|auto||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/cbd-antidepresivos-largo-plazo.jpg” alt=”cbd antidepressivos de longo prazo” title_text=”cbd antidepressivos de longo prazo” align=”center” _builder_version=”4.16″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n No que diz respeito aos efeitos antidepressivos do CBD canabidiol a longo prazo, os cientistas descobriram que estavam associados a uma melhoria da fun\u00e7\u00e3o sin\u00e1ptica no c\u00f3rtex pr\u00e9-frontal.<\/strong> Este foi o teste de nata\u00e7\u00e3o em ratos avaliado 7 dias ap\u00f3s a dose de CBD.<\/p>\n Os resultados apoiam a teoria de que o canabidiol cbd extra\u00eddo da can\u00e1bis \u00e9 na verdade um antidepressivo de a\u00e7\u00e3o r\u00e1pida. N\u00e3o s\u00f3 isso, mas os seus efeitos antidepressivos tamb\u00e9m s\u00e3o sustentados. Por outras palavras, o consumo de CBD em doses adequadas pode conduzir a uma atividade anti-depressiva a longo prazo.<\/p>\n Embora seja \u00f3bvio que s\u00e3o necess\u00e1rias mais investiga\u00e7\u00f5es sobre o assunto, os resultados destes estudos sugerem que o CBD pode ser um tratamento terap\u00eautico promissor para combater as perturba\u00e7\u00f5es do humor e, mais especificamente, a depress\u00e3o.<\/p>\n N\u00e3o devemos esquecer que o CBD j\u00e1 \u00e9 conhecido pelos seus benef\u00edcios para a sa\u00fade noutras condi\u00e7\u00f5es, como a doen\u00e7a de Alzheimer, a dor cr\u00f3nica ou a disfun\u00e7\u00e3o neurol\u00f3gica. Por conseguinte, n\u00e3o seria estranho se tamb\u00e9m tivesse um efeito positivo no tratamento da depress\u00e3o.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.16″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.16″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_enable_image=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/cbd-depresion.jpg” alt=”depres\u00e7\u00e3o cbd” title_text=”depres\u00e7\u00e3o cbd” force_fullwidth=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_cta title=”O papel do CBD na depress\u00e3o” button_url=”#top” _builder_version=”4.16″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]Como mencionado acima, as op\u00e7\u00f5es atuais de tratamento para a depress\u00e3o, que inclui o uso de antidepressivos, podem ser problem\u00e1ticas. Isto deve-se principalmente ao facto de os doentes terem muitas vezes de lidar com um atraso associado aos seus efeitos. Neste sentido, o CBD pode ter o potencial de ser uma alternativa eficiente no combate \u00e0 depress\u00e3o.<\/strong><\/p>\n Uma investiga\u00e7\u00e3o de 2019 revelou que o canabidiol (CBD) induz efeitos semelhantes a antidepressivos de a\u00e7\u00e3o r\u00e1pida e sustentados.<\/a> Tudo isto atrav\u00e9s do aumento da sinaliza\u00e7\u00e3o e da sintanogenose da BDNF no c\u00f3rtex pr\u00e9-frontal do c\u00e9rebro. Investigadores da Universidade de S\u00e3o Paulo, no Brasil, analisaram os efeitos antidepressivos do CBD<\/strong> em ratos e ratos para determinar se este canabidiol tem um r\u00e1pido in\u00edcio de a\u00e7\u00e3o.<\/p>\n Durante a investiga\u00e7\u00e3o, o CBD foi administrado como uma dose \u00fanica numa quantidade que poderia ser de 7, 10 ou 30 mg por quilo de peso corporal. Os cientistas submeteram os roedores a um teste de nata\u00e7\u00e3o for\u00e7ada, ap\u00f3s 30 minutos ou at\u00e9 7 dias ap\u00f3s o in\u00edcio do tratamento.[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Subscribe” _builder_version=”4.16″ use_background_color_gradient=”on” background_color_gradient_stops=”#f3f3f1 0%|rgba(255,255,255,0) 30%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#f3f3f1″ background_color_gradient_end=”rgba(255,255,255,0)” background_color_gradient_end_position=”30%” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/aceite-de-cannabis-cbd.jpg” custom_padding=”100px|0px|30vw|0px” animation_direction=”bottom” saved_tabs=”all” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text 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custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”89px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” border_radii_fields=”on|30px|30px|30px|30px” border_width_all_fields=”1px” border_color_all_fields=”rgba(47,56,84,0.2)” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” 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header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png” alt=”s\u00edmbolo do higea” title_text=”s\u00edmbolo do higea” _builder_version=”4.16″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n 5% CDB<\/a><\/p>\n [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]10% CDB<\/a>[\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n 20% CDB<\/a><\/p>\n [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]30% CDB<\/a>[\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n B\u00e1lsamo de Cura<\/a><\/p>\n [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n Crema dolor muscular<\/a><\/p>\n [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” 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_dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”#00205c” custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” 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button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” custom_margin_phone=”||60px||false|false” custom_margin_last_edited=”off|tablet” custom_padding=”1px|0px|1px|0px|true|true” custom_padding_tablet=”14px||14px||true|true” custom_padding_phone=”1px||1px||true|true” custom_padding_last_edited=”off|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#00a88d” locked=”off” global_colors_info=”{}” button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#ffffff” box_shadow_color__hover_enabled=”off|hover” box_shadow_color__hover=”#e14a00″][\/et_pb_button][et_pb_button button_url=”https:\/\/higeacbd.com\/pt-pt\/loja\/cremes” button_text=”Cremes” _builder_version=”4.16″ _dynamic_attributes=”button_url” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” custom_margin_phone=”||60px||false|false” custom_margin_last_edited=”off|tablet” custom_padding=”1px|0px|1px|0px|true|true” custom_padding_tablet=”14px||14px||true|true” custom_padding_phone=”1px||1px||true|true” custom_padding_last_edited=”off|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#00a88d” locked=”off” global_colors_info=”{}” button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#ffffff” box_shadow_color__hover_enabled=”off|hover” box_shadow_color__hover=”#e14a00″][\/et_pb_button][et_pb_button 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header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_color=”#ffffff” custom_padding=”80px|60px|80px|60px|true|true” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#000000″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png” alt=”s\u00edmbolo do higea” title_text=”s\u00edmbolo do higea” _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#000000″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n AVISO LEGAL<\/a><\/p>\n [\/et_pb_blurb][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#000000″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]PRIVACIDADE E COOKIES<\/a>[\/et_pb_blurb][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#000000″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n POL\u00cdTICA DE DEVOLU\u00c7\u00c3O<\/a><\/p>\n [\/et_pb_blurb][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#000000″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]contato<\/a>[\/et_pb_blurb][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font_size=”15px” global_colors_info=”{}”]pedidos@higeacbd.com<\/a>[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/formas-de-pago.png” alt=”op\u00e7\u00f5es de pagamento” title_text=”op\u00e7\u00f5es de pagamento” _builder_version=”4.16″ _module_preset=”default” custom_margin=”10px||10px||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text admin_label=”DMCA protected” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”] Como funcionam os antidepressivos? Um novo estudo revela a verdade<\/h2>\n
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BDNF e a sua rela\u00e7\u00e3o com a plasticidade neural<\/h2>\n
Cetamina tem um efeito antidepressivo mais r\u00e1pido<\/h2>\n
O colesterol pode desempenhar um papel fundamental na forma como os antidepressivos funcionam<\/h2>\n
\u00c9 necess\u00e1ria mais investiga\u00e7\u00e3o sobre colesterol e antidepressivos<\/h2>\n
Porque \u00e9 que os antidepressivos funcionam mais depressa do que os outros?<\/h2>\n
Pontos-chave da investiga\u00e7\u00e3o<\/h2>\n
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Efeitos antidepressivos do CBD a curto prazo<\/h2>\n
Efeitos antidepressivos a longo prazo do CBD<\/h2>\n
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