Dans le premier moment, nous allons d\u00e9finir quelques termes pharmacologiques qui nous aideront tout au long du texte \u00e0 comprendre beaucoup mieux les concepts complexes qui nous aideront \u00e0 choisir le dosage id\u00e9al.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Produits” _builder_version=”4.7.7″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_module=”16824″][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default” background_enable_color=”off”][et_pb_shop type=”best_selling” posts_number=”8″ show_pagination=”on” module_class=”custom-shop” _builder_version=”4.8.1″ _module_preset=”default” title_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false”][\/et_pb_shop][et_pb_signup mailchimp_list=”higeacbd|5b4d14cf0e” first_name_field=”off” last_name_field=”off” title=”Abonnez-vous et b\u00e9n\u00e9ficiez d\u2019une r\u00e9duction de 10%” _builder_version=”4.8.1″ header_level=”h4″ header_font=”|800|||||||” header_text_align=”center” header_text_color=”#000000″ header_font_size=”35px” header_line_height=”1.2em” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” button_custom_padding=”18px|0px|18px|0px|true|true” button_custom_padding_tablet=”14px||14px||true|true” button_custom_padding_phone=”12px||12px||true|true” button_custom_padding_last_edited=”on|phone” background_layout=”light” header_font_size_tablet=”25px” header_font_size_phone=”20px” header_font_size_last_edited=”on|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style_button=”preset4″ box_shadow_horizontal_button=”0px” box_shadow_vertical_button=”2px” box_shadow_color_button=”#00a88d” button_text_color__hover=”#28221d” button_text_color__hover_enabled=”on|hover” box_shadow_color_button__hover=”#000000″ box_shadow_color_button__hover_enabled=”on|desktop”][\/et_pb_signup][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” background_color=”#f3f3f1″ custom_padding=”14px||27px|||”][et_pb_row _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”12px||13px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.6.6″ _module_preset=”default” header_2_font=”|800|||||||” header_2_text_align=”center” header_2_font_size=”35px” header_2_line_height=”1.2em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||-5px|||” custom_padding=”||0px|||”]<\/p>\n
Pharmacocin\u00e9tique<\/h2>\n
Son \u00e9tymologie nous donne d\u00e9j\u00e0 une id\u00e9e de ce que cette branche de la science peut traiter. D\u2019une part, \u00ab pharmaco \u00bb nous dit qu\u2019il est li\u00e9 \u00e0 la pharmacologie<\/a> et \u00e0 la \u00ab cin\u00e9tique \u00bb, nous pouvons d\u00e9duire que cela a \u00e0 voir avec quelque chose qui est en mouvement. En effet, pharmacocin\u00e9tique \u00e9tudie comment les m\u00e9dicaments se d\u00e9placent \u00e0 travers notre corps, d\u2019entrer \u00e0 quitter notre corps.<\/p>\n Il se r\u00e9f\u00e8re \u00e0 l\u2019endroit o\u00f9 une substance entre dans notre organisme. Il peut \u00eatre intraveineux, oral, topique, rectal, etc…<\/p>\n C\u2019est l\u2019organisme cible sur lequel les m\u00e9dicaments fonctionnent. Ce sont g\u00e9n\u00e9ralement des prot\u00e9ines, des lipides et des acides nucl\u00e9iques.<\/p>\n En pharmacocin\u00e9tique, l\u2019absorption du processus de p\u00e9n\u00e9tration des m\u00e9dicaments par les membranes cellulaires pour atteindre le sang est appel\u00e9e absorption. L\u2019administration intraveineuse saute directement le processus d\u2019absorption.<\/p>\n Il se r\u00e9f\u00e8re \u00e0 la fa\u00e7on dont le m\u00e9dicament se d\u00e9place \u00e0 travers le sang vers les diff\u00e9rents tissus du corps.<\/p>\n Notre corps transforme les m\u00e9dicaments en sous-produits pour faciliter leur \u00e9limination. Un m\u00e9dicament qui est fourni par voie orale passera toujours par le filtre m\u00e9tabolique qui le brisera en sous-produits et ne passera pas dans la circulation sanguine \u00e0 100%<\/p>\n C\u2019est le processus par lequel notre corps finit par enlever les m\u00e9dicaments<\/p>\n C\u2019est la quantit\u00e9 de drogue qui passe dans la circulation sanguine et est disponible pour notre corps.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”Ligne CTA” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-cbd.jpg” alt=”biodisponibilit\u00e9 cbd” title_text=”biodisponibilit\u00e9 cbd” force_fullwidth=”on” _builder_version=”4.5.8″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”Alors, qu\u2019est-ce que la biodisponibilit\u00e9?” button_url=”#top” _builder_version=”4.5.8″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n En pharmacocin\u00e9tique, la biodisponibilit\u00e9 d\u2019un m\u00e9dicament<\/strong> fait partie de l\u2019\u00e9tude de l\u2019absorption et est le pourcentage et le taux auquel le compos\u00e9 atteint le plasma dans notre circulation syst\u00e9mique. Par cons\u00e9quent, si un m\u00e9dicament est livr\u00e9 par voie intraveineuse (IV), par d\u00e9finition, sa biodisponibilit\u00e9 est de 100%.<\/strong> Notre corps aurait alors 100% du compos\u00e9 disponible dans le syst\u00e8me circulatoire pour atteindre la cible th\u00e9rapeutique.<\/p>\n Par cons\u00e9quent, nous pouvons d\u00e9duire que pour calculer la biodisponibilit\u00e9 d\u2019un m\u00e9dicament,<\/strong> il est essentiel de diff\u00e9rencier les voies de l\u2019administration. Le tableau suivant d\u00e9taille la biodisponibilit\u00e9 pour chaque voie :<\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” background_color=”#f3f3f1″ custom_padding=”14px||27px|||”][et_pb_row _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”12px||13px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.5.8″ _module_preset=”default” header_2_font=”|800|||||||” header_2_text_align=”center” header_2_font_size=”35px” header_2_line_height=”1.2em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||-5px|||” custom_padding=”||0px|||”]<\/p>\n La fa\u00e7on la plus courante et la plus s\u00fbre de prendre n\u2019importe quel m\u00e9dicament \u00e0 la maison est orale. Lorsque nous ingons un m\u00e9dicament, il est absorb\u00e9 par le foie qui est responsable de le passer dans la circulation sanguine. Cependant, pas tous les m\u00e9dicaments atteint notre circulation syst\u00e9mique, comme le foie premi\u00e8re \u00e9tape du m\u00e9tabolisme d\u00e9compose certaines des substances actives qui ne circuleront jamais \u00e0 travers notre corps. Par cons\u00e9quent, lorsque nous voulons calculer la biodisponibilit\u00e9 d\u2019un m\u00e9dicament administr\u00e9 par voie orale, nous devrions \u00e9galement prendre en compte cet effet du m\u00e9tabolisme de la premi\u00e8re \u00e9tape h\u00e9patique.<\/p>\n Certains compos\u00e9s (comme le CBD dont nous discuterons plus tard) ont un grand effet de premi\u00e8re \u00e9tape afin administr\u00e9 par voie orale ne pas atteindre suffisamment de concentration plasmatique pour atteindre l\u2019objectif th\u00e9rapeutique. Dans ces cas, il est indiqu\u00e9 de chercher une autre voie d\u2019administration. La fa\u00e7on la plus courante et la plus s\u00fbre de prendre n\u2019importe quel m\u00e9dicament \u00e0 la maison est orale. Lorsque nous ingons un m\u00e9dicament, il est absorb\u00e9 par le foie qui est responsable de le passer dans la circulation sanguine. Cependant, pas tous les m\u00e9dicaments atteint notre circulation syst\u00e9mique, comme le foie premi\u00e8re \u00e9tape du m\u00e9tabolisme d\u00e9compose certaines des substances actives qui ne circuleront jamais \u00e0 travers notre corps.<\/p>\n Par cons\u00e9quent, lorsque nous voulons calculer la biodisponibilit\u00e9 d\u2019un m\u00e9dicament administr\u00e9 par voie orale, nous devrions \u00e9galement prendre en compte cet effet du m\u00e9tabolisme de la premi\u00e8re \u00e9tape h\u00e9patique. Certains compos\u00e9s (comme le CBD dont nous discuterons plus tard) ont un grand effet de premi\u00e8re \u00e9tape afin administr\u00e9 par voie orale ne pas atteindre suffisamment de concentration plasmatique pour atteindre l\u2019objectif th\u00e9rapeutique. Dans ces cas, il est indiqu\u00e9 de chercher une autre voie d\u2019administration.<\/p>\n L\u2019administration sublinguale,<\/a>par exemple, augmente la biodisponibilit\u00e9 du m\u00e9dicament puisque sous la langue nous avons d\u2019innombrables capillaires et le tissu est assez perm\u00e9able pour que la substance passe directement dans la circulation sanguine. Voici quelques exemples de biodisponibilit\u00e9 de certains m\u00e9dicaments que nous connaissons mieux :<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”40px||40px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.4.4″ locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.4.4″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-en-alimentos.jpg” alt=”biodisponibilit\u00e9 dans les aliments” title_text=”biodisponibilit\u00e9 dans les aliments” _builder_version=”4.5.8″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.8″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.9.2″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n L’\u00e9tude de la biodisponibilit\u00e9<\/strong> des nutriments dans les aliments<\/a><\/strong> est fondamentale pour comprendre comment nourrir l’ensemble de la population avec les ressources disponibles. C\u2019est pourquoi d\u2019\u00e9normes efforts sont d\u00e9ploy\u00e9s pour comprendre la biodisponibilit\u00e9 des nutriments dans chaque aliment et quels facteurs de l\u2019individu peuvent l\u2019influencer.<\/p>\n Les macronutriments (prot\u00e9ines, glucides et graisses) atteignent une biodisponibilit\u00e9 pouvant atteindre 90%. Puisque les macronutriments jouissent d\u2019une biodisponibilit\u00e9 si \u00e9lev\u00e9e, la valeur biologique est donn\u00e9e une grande importance, par exemple, nous pr\u00e9f\u00e9rons les graisses insatur\u00e9es riches en acides om\u00e9ga 3, 6 et 9 et prot\u00e9ines qui contiennent la plus grande quantit\u00e9 d\u2019acides amin\u00e9s essentiels que notre corps n\u2019est pas en mesure de synth\u00e9tiser.<\/p>\n Cependant, l\u2019\u00e9tude de la biodisponibilit\u00e9 des micronutriments tels que les vitamines et les min\u00e9raux est beaucoup plus compliqu\u00e9e que leur processus digestif est plus complexe et implique beaucoup plus de facteurs qui modifient la biodisponibilit\u00e9 de ces derniers dans chaque individu.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”Ligne CTA” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-en-el-cbd.jpg” alt=”biodisponibilit\u00e9 en cbd” title_text=”biodisponibilit\u00e9 en cbd” force_fullwidth=”on” _builder_version=”4.5.8″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”Quelle est la biodisponibilit\u00e9 de l\u2019huile de CBD? Quel est le chemin d\u2019administration optimal?” button_url=”#top” _builder_version=”4.5.8″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n Plusieurs fois, nous regardons la concentration d\u2019huiles<\/a> avant de nous arr\u00eater de penser exactement combien nous avons besoin de traiter notre probl\u00e8me. C\u2019est pourquoi, ensuite, nous allons essayer de comprendre comment notre corps absorbe le CBD. Rappelez-vous que la voie par laquelle nous l\u2019administrons d\u00e9terminera son absorption et sa biodisponibilit\u00e9.<\/p>\n L\u2019une des voies d\u2019administration les plus courantes est dans les capsules comestibles qui passeront par notre syst\u00e8me digestif et cbd sera absorb\u00e9 par le foie. CBD a un effet assez \u00e9lev\u00e9 de m\u00e9tabolisme de premier temps de foie, ainsi notre foie le d\u00e9composera laissant une biodisponibilit\u00e9 aussi basse que 4% – 20% (selon des \u00e9tudes r\u00e9centes). Bien s\u00fbr, l\u2019industrie tente de r\u00e9pondre \u00e0 ce probl\u00e8me de biodisponibilit\u00e9 cbd oralement et en \u00e9tudiant les \u00e9mulsions solubles dans l\u2019eau qui augmentent l\u2019absorption et la biodisponibilit\u00e9 jusqu\u2019\u00e0 pr\u00e8s de 50%. Si nous optons pour cette voie d\u2019administration, nous devrions \u00e9galement prendre en compte si notre estomac est vide ou plein avant de consommer les capsules. Cbd est liposoluble qui, si nous l\u2019accompagnons avec des repas riches en mati\u00e8res grasses, nous pouvons augmenter sa biodisponibilit\u00e9 orale.<\/p>\n <\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.5.1″ custom_margin=”|auto|-2px|auto||” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.5.1″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/farmacodinamia-cannabinoides.jpg” alt=”pharmacodynamique cannabino\u00efdes” title_text=”pharmacodynamique cannabino\u00efdes” align=”center” _builder_version=”4.5.8″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.9.0″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n L\u2019administration sublinguale de n\u2019importe quel m\u00e9dicament augmentera automatiquement la biodisponibilit\u00e9 du m\u00e9dicament car les muqueuses absorberont une partie de la substance active directement dans la circulation sanguine. Pour ce faire, vous devrez garder les gouttelettes d\u2019huile pendant 90 secondes sous votre langue avant de les avaler. Avec l\u2019administration sublinguale, vous pouvez atteindre 12% \u00e0 35% de biodisponibilit\u00e9 de CBD.<\/p>\n Lorsque vaping huiles CBD nous inhalons le compos\u00e9 qui atteint notre poumon. Les alv\u00e9oles pulmonaires seront responsables du transport de la substance active tr\u00e8s rapidement dans la circulation sanguine afin que l\u2019absorption soit presque instantan\u00e9e et qu\u2019une biodisponibilit\u00e9 sup\u00e9rieure \u00e0 50% puisse \u00eatre r\u00e9alis\u00e9e.<\/p>\n Il ya d\u2019innombrables cr\u00e8mes et baumes avec CBD comme une substance active. La peau est une membrane tr\u00e8s dense et une faible perm\u00e9abilit\u00e9 qui affecte directement l\u2019absorption. C\u2019est pour cette raison que si nous choisissons la voie d\u2019actualit\u00e9 pour profiter des avantages de la CDB, nous devrons examiner beaucoup la concentration de Cannabidiol de ces produits. C\u2019est la meilleure fa\u00e7on d\u2019apaiser les douleurs localis\u00e9es, les couches denses de produit doivent \u00eatre appliqu\u00e9es sur la peau et laisser travailler jusqu\u2019\u00e0 ce que la peau finit absorbant. De toute fa\u00e7on, l’application d’une concentration de CBD sur la peau<\/a> ne la fera pas passer dans la circulation sanguine, de sorte que sa biodisponibilit\u00e9 est nulle. Il y a des taches transdermiques de CBD qui sont absorb\u00e9es dans la circulation sanguine, mais leur biodisponibilit\u00e9 exacte n\u2019est pas encore connue.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.5.1″ custom_margin=”|auto|-2px|auto||” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.5.1″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/porque-tenemos-receptores-cannabinoides.jpg” alt=”parce que nous avons des r\u00e9cepteurs cannabino\u00efdes” title_text=”parce que nous avons des r\u00e9cepteurs cannabino\u00efdes” align=”center” _builder_version=”4.5.8″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.8″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”off|desktop”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.9.3″ hover_enabled=”0″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” sticky_enabled=”0″]<\/p>\n Jusqu\u2019\u00e0 pr\u00e9sent, nous n\u2019avons parl\u00e9 que de la biodisponibilit\u00e9 des cannabino\u00efdes isol\u00e9s de CBD. Certaines \u00e9tudes montrent que la combinaison du CBD avec d’autres cannabino\u00efdes et terp\u00e8nes naturellement pr\u00e9sents dans la plante de chanvre, comme le ga\u00efol ocim\u00e8ne<\/a> ou l’humul\u00e8ne<\/a>, augmente la biodisponibilit\u00e9 du compos\u00e9, quelle que soit la voie d’administration.<\/p>\n Sur le march\u00e9, nous pouvons trouver:<\/p>\n Selon la dose et la voie d\u2019administration, notre corps prendra plus ou moins de temps pour distribuer et retirer le CBD de notre syst\u00e8me.<\/a> Les effets peuvent plusieurs \u00e0 8 heures et leur \u00e9limination compl\u00e8te ne d\u00e9passe g\u00e9n\u00e9ralement pas une semaine.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Art\u00edculos relacionados blog” _builder_version=”4.7.0″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||9px|||” locked=”off”][et_pb_row _builder_version=”4.5.1″ 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_builder_version=”4.5.1″ use_background_color_gradient=”on” background_color_gradient_start=”#f3f3f1″ background_color_gradient_end=”rgba(255,255,255,0)” background_color_gradient_end_position=”30%” background_color_gradient_overlays_image=”on” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/aceite-de-cannabis-cbd.jpg” custom_padding=”100px|0px|30vw|0px” animation_style=”slide” animation_direction=”bottom” animation_duration=”1250ms” animation_intensity_slide=”1%” saved_tabs=”all”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ text_font=”|500|||||||” text_text_color=”rgba(47,56,84,0.5)” text_font_size=”16px” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”|700|||||||” header_2_font_size=”50px” header_2_line_height=”1.3em” text_orientation=”center” max_width=”700px” module_alignment=”center”]<\/p>\n Abonnez-vous et b\u00e9n\u00e9ficiez d\u2019une r\u00e9duction de 10% sur votre achat. <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_2,1_4″ _builder_version=”3.25″ custom_padding=”19px|||||”][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_signup mailchimp_list=”higeacbd|5b4d14cf0e” first_name_field=”off” last_name_field=”off” _builder_version=”4.5.1″ header_font=”||||||||” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”89px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” border_radii_fields=”on|30px|30px|30px|30px” border_width_all_fields=”1px” border_color_all_fields=”rgba(47,56,84,0.2)” 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_builder_version=”4.8.2″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Comment prendre de l\u2019huile de CBD” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjUzMiJ9fQ==@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.5.1″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Qu\u2019est-ce que la CDB” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjU4NyJ9fQ==@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.5.1″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Avantages cbd” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjY1OSJ9fQ==@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.5.1″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” header_font_size_tablet=”14px” 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_dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#ffffff” header_4_font_size=”14px” header_4_letter_spacing=”2px” 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url=”https:\/\/higeacbd.com\/fr\/huiles\/methodes-dextraction-de-cbd” use_icon=”on” font_icon=”%%53%%” icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.8.1″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Huiles porteuses” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIzNzcifX0=@” use_icon=”on” font_icon=”%%53%%” icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.5.5″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” header_font_size_tablet=”14px” header_font_size_phone=”12px” 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custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#000000″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png” alt=”simboolo higea” title_text=”simboolo higea” _builder_version=”4.5.1″ locked=”off”][\/et_pb_image][et_pb_blurb title=”Avertissement” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE3MCJ9fQ==@” url_new_window=”on” use_icon=”on” font_icon=”%%53%%” icon_color=”#000000″ icon_placement=”left” _builder_version=”4.5.1″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_text_color=”#000000″ custom_margin=”||0px||false|false” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Confidentialit\u00e9 et cookies” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjMifX0=@” url_new_window=”on” use_icon=”on” font_icon=”%%53%%” icon_color=”#000000″ icon_placement=”left” _builder_version=”4.5.1″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_text_color=”#000000″ custom_margin=”||0px||false|false” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Strat\u00e9gie de retour” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6Ijc4MTgifX0=@” url_new_window=”on” use_icon=”on” font_icon=”%%53%%” icon_color=”#000000″ icon_placement=”left” _builder_version=”4.6.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_text_color=”#000000″ custom_margin=”||0px||false|false” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Contact” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjY0MiJ9fQ==@” url_new_window=”on” use_icon=”on” font_icon=”%%53%%” icon_color=”#000000″ icon_placement=”left” _builder_version=”4.6.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_text_color=”#000000″ custom_margin=”||0px||false|false” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_text _builder_version=”4.6.5″ _module_preset=”default” text_font_size=”15px”]pedidos@higeacbd.com<\/a>[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/formas-de-pago.png” alt=”m\u00e9thodes de paiement” title_text=”m\u00e9thodes de paiement” _builder_version=”4.6.5″ _module_preset=”default” custom_margin=”10px||10px||false|false”][\/et_pb_image][et_pb_text admin_label=”DMCA protected” _builder_version=”4.6.5″ _module_preset=”default” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false”] Itin\u00e9raire d\u2019administration<\/h2>\n
Diana Th\u00e9rapeutique<\/h2>\n
Absorption<\/h2>\n
Distribution<\/h2>\n
M\u00e9tabolisme<\/h2>\n
Excr\u00e9tion<\/h2>\n
Concentration plasmatique<\/h2>\n
![\"Biodisponibilit\u00e9\"](\"https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad.jpg\")
<\/p>\n![\"courbe](\"https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/curva-de-concentracion-plasmatica.jpg\")
<\/p>\n\n
Voici d\u2019autres facteurs qui influent sur la biodisponibilit\u00e9 d\u2019un m\u00e9dicament :<\/h3>\n
\n
La biodisponibilit\u00e9 des nutriments dans les aliments<\/h2>\n
Capsules orales<\/h3>\n
La CDB se concentre sublingualement<\/h3>\n
Vaping e-liquide (inhalation)<\/h3>\n
Utilisation topique<\/h3>\n
Synergies qui augmentent la biodisponibilit\u00e9 : Terp\u00e8nes, flavono\u00efdes et autres cannabino\u00efdes<\/h2>\n
\n
Combien de temps faut-il pour que notre corps \u00e9limine compl\u00e8tement le CBD?<\/h2>\n
Articles connexes<\/h4>\n
Abonnez-vous \u00e0 notre newsletter<\/h2>\n
boutique<\/h4>\n
Guides<\/h4>\n
En savoir plus<\/h4>\n
Avis juridique et politique de confidentialit\u00e9<\/h4>\n
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<\/a><\/p>\n