{"id":57532,"date":"2021-07-09T13:12:34","date_gmt":"2021-07-09T13:12:34","guid":{"rendered":"https:\/\/higeacbd.com\/?p=57532"},"modified":"2021-12-03T13:32:30","modified_gmt":"2021-12-03T13:32:30","slug":"recepteurs-vanilloides","status":"publish","type":"post","link":"https:\/\/higeacbd.com\/fr\/datos\/recepteurs-vanilloides","title":{"rendered":"R\u00e9cepteurs vanillo\u00efdes"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Hero” _builder_version=”4.9.7″ background_color=”rgba(255,255,255,0.65)” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/07\/los-receptores-vaniloides-1.jpg” background_blend=”soft-light” custom_padding=”3vw||1vw|||” global_colors_info=”{}”][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_cta title=”R\u00e9cepteurs vanillo\u00efdes” _builder_version=”4.9.7″ header_level=”h1″ header_font=”|800|||||||” header_font_size=”45px” header_line_height=”1.3em” body_font=”|800|||||||” body_text_color=”#000000″ body_font_size=”20px” body_line_height=”1.6em” use_background_color=”off” custom_button=”on” button_text_size=”14px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_width=”8px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” background_layout=”light” animation_direction=”bottom” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” button_text_color_hover=”#ffffff” button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”rgba(47,56,84,0.9)” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”rgba(47,56,84,0.9)” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Products” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”20px||11px||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.5.1″ custom_padding=”8px||17px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.14.2″ text_font=”|500|||||||” text_text_color=”#000000″ quote_font=”||||||||” header_font=”||||||||” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.4em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||12px|||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Dans cet article, nous allons parler des r\u00e9cepteurs vanillo\u00efdes<\/strong>, dont l’activation peut jouer un r\u00f4le important dans une vari\u00e9t\u00e9 de fonctions physiologiques. Il s’agit notamment de la lib\u00e9ration de m\u00e9diateurs inflammatoires dans l’organisme, de la motilit\u00e9 gastro-intestinale et de la r\u00e9gulation de la temp\u00e9rature.<\/p>\n

En effet, le r\u00e9cepteur \u00e0 potentiel transitoire V1, connu simplement sous le nom de TRPV1, joue un r\u00f4le essentiel dans les \u00e9tats physiologiques et pathologiques du tube digestif<\/strong>. Elle est \u00e9galement importante pour les syst\u00e8mes cardiovasculaire et respiratoire, selon un grand nombre de recherches publi\u00e9es ces derni\u00e8res ann\u00e9es.<\/p>\n

L’objectif de cet article est d’expliquer la fonction et les effets des r\u00e9cepteurs vanillo\u00efdes <\/strong>dans des maladies sp\u00e9cifiques telles que le syndrome du c\u00f4lon irritable<\/a>, l’hypertension<\/a> et l’asthme<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Produits” _builder_version=”4.7.7″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_module=”16824″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_shop type=”best_selling” posts_number=”8″ show_pagination=”on” module_class=”custom-shop” _builder_version=”4.13.0″ _module_preset=”default” title_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][\/et_pb_shop][et_pb_signup mailchimp_list=”higeacbd|5b4d14cf0e” first_name_field=”off” last_name_field=”off” title=”Abonnez-vous et b\u00e9n\u00e9ficiez d\u2019une r\u00e9duction de 10%” disabled_on=”off|off|off” _builder_version=”4.13.0″ header_level=”h4″ header_font=”|800|||||||” header_text_align=”center” header_text_color=”#000000″ header_font_size=”35px” header_line_height=”1.2em” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” button_custom_padding=”18px|0px|18px|0px|true|true” button_custom_padding_tablet=”14px||14px||true|true” button_custom_padding_phone=”12px||12px||true|true” button_custom_padding_last_edited=”on|phone” background_layout=”light” header_font_size_tablet=”25px” header_font_size_phone=”20px” header_font_size_last_edited=”on|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style_button=”preset4″ box_shadow_horizontal_button=”0px” box_shadow_vertical_button=”2px” box_shadow_color_button=”#00a88d” global_colors_info=”{}” button_text_color__hover=”#28221d” button_text_color__hover_enabled=”on|hover” box_shadow_color_button__hover=”#000000″ box_shadow_color_button__hover_enabled=”on|desktop”][\/et_pb_signup][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” background_color=”#f3f3f1″ custom_padding=”14px||27px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”12px||13px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.10.3″ _module_preset=”default” header_2_font=”|800|||||||” header_2_text_align=”center” header_2_font_size=”35px” header_2_line_height=”1.2em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||-5px|||” custom_padding=”||0px|||” header_2_font_size_tablet=”25px” header_2_font_size_phone=”20px” header_2_font_size_last_edited=”on|tablet” global_colors_info=”{}”]<\/p>\n

En quoi consistent les r\u00e9cepteurs vanillo\u00efdes ?<\/h2>\n

Les TRPV1 \/ TRPV2, TRPV3, TRPV4 et TRPV5 \/ TRPV6 sont des membres de la sous-famille des r\u00e9cepteurs \u00e0 potentiel transitoire (TRPV), qui est class\u00e9e en quatre groupes en fonction de leur homologie. Les membres de la sous-famille TRPV agissent comme des complexes t\u00e9tram\u00e9riques avec six r\u00e9p\u00e9titions d’ankyrine N-terminales dans chaque sous-unit\u00e9.<\/p>\n

Tous ces r\u00e9cepteurs vanillo\u00efdes peuvent jouer des r\u00f4les diff\u00e9rents dans l’organisme, en raison de leurs diff\u00e9rences de structure et de distribution<\/strong>. Par exemple, le r\u00e9cepteur TRPV1 agit comme un r\u00e9cepteur multisensoriel pour les signaux de dommages potentiels, et est impliqu\u00e9 dans de nombreuses fonctions essentielles telles que la contraction des cellules musculaires.<\/p>\n

Le r\u00e9cepteur TRPV3, quant \u00e0 lui, est essentiel \u00e0 de multiples fonctions de la peau, notamment la barri\u00e8re cutan\u00e9e et la morphogen\u00e8se du poil<\/a>. Mais par rapport aux autres, le r\u00e9cepteur TRPV1 est le principal canal de d\u00e9tection et d’int\u00e9gration des stimuli thermiques et chimiques nociceptifs dans les fibres nerveuses sensorielles.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”Ligne CTA” module_class=” et_pb_row_fullwidth” _builder_version=”4.8.2″ background_color=”#00a88d” width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/07\/receptores-vaniloides.jpg” alt=”les r\u00e9cepteurs vanillo\u00efdes” title_text=”les r\u00e9cepteurs vanillo\u00efdes” force_fullwidth=”on” _builder_version=”4.9.7″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.8.2″ background_enable_color=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_cta title=”Structure des r\u00e9cepteurs vanillo\u00efdes TRPV1″ button_url=”#top” _builder_version=”4.9.7″ header_font=”|800|||||||” header_text_color=”#ffffff” header_font_size=”35px” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” header_font_size_tablet=”25px” header_font_size_phone=”20px” header_font_size_last_edited=”on|desktop” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n

Les r\u00e9cepteurs vanillo\u00efdes ont une structure t\u00e9tram\u00e9rique compos\u00e9e de six r\u00e9gions transmembranaires<\/strong> ainsi que d’un groupe hydrophobe situ\u00e9 entre les cinqui\u00e8me et sixi\u00e8me r\u00e9gions transmembranaires.<\/p>\n

Les chercheurs ont analys\u00e9 la structure de TRPV1 \u00e0 l’aide de la microscopie cryo-\u00e9lectronique \u00e0 une r\u00e9solution de 19\u00c5. Au cours de cette \u00e9tude, la structure g\u00e9n\u00e9rale des r\u00e9cepteurs vanillo\u00efdes a \u00e9t\u00e9 divis\u00e9e en parties sup\u00e9rieure et inf\u00e9rieure, correspondant aux r\u00e9gions transmembranaire et intracellulaire du canal.<\/p>\n

Il a \u00e9galement \u00e9t\u00e9 constat\u00e9 que la structure des r\u00e9cepteurs vanillo\u00efdes pr\u00e9sente des dimensions de longueur, de largeur et de hauteur, correspondant respectivement \u00e0 100 \u00c5 \u00d7 110 \u00c5 \u00d7 110 \u00c5. L’\u00e9tude a \u00e9galement r\u00e9v\u00e9l\u00e9 l’existence d’un m\u00e9canisme de r\u00e9gulation \u00e0 double porte pour ces r\u00e9cepteurs.<\/p>\n

Dans ce cas, on a d\u00e9couvert que les cinqui\u00e8me et sixi\u00e8me r\u00e9gions prot\u00e9iques transmembranaires de chaque sous-unit\u00e9 TRPV1 se combinent pour former une r\u00e9gion poreuse dans le canal.<\/p>\n

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Caract\u00e9ristiques biologiques et distribution de TRPV1<\/h2>\n

Chez les mammif\u00e8res, les r\u00e9cepteurs vanillo\u00efdes sont largement distribu\u00e9s dans les fibres nerveuses sensorielles amy\u00e9linis\u00e9es de type C<\/strong> et partiellement distribu\u00e9s dans les fibres nerveuses sensorielles moins my\u00e9linis\u00e9es de type A\u03b4.<\/p>\n

Dans notre syst\u00e8me neuronal p\u00e9riph\u00e9rique, ces fibres se trouvent dans le ganglion de la racine dorsale, le ganglion trig\u00e9minal, ainsi que dans le ganglion vagal, et dans d’autres petits neurones. Dans le syst\u00e8me nerveux central, ils sont exprim\u00e9s dans le thalamus, l’amygdale, le striatum et d’autres r\u00e9gions.<\/p>\n

L’importance des r\u00e9cepteurs vanillo\u00efdes tient au fait qu’ils sont pr\u00e9sents dans le pancr\u00e9as, le c\u0153ur, le foie, les poumons et d’autres organes vitaux du<\/strong> corps humain. Dans le tractus intestinal, le potentiel r\u00e9cepteur transitoire V1 est distribu\u00e9 principalement dans le plexus nerveux sous-muqueux du tractus intestinal.<\/p>\n

On le trouve \u00e9galement dans le plexus nerveux myent\u00e9rique, dans la muqueuse du muscle gastro-intestinal, ainsi que dans certains tissus non nerveux, comme les cellules de la muqueuse gastrique.<\/p>\n

Gr\u00e2ce \u00e0 la recherche, on sait que les r\u00e9cepteurs vanillo\u00efdes sont largement distribu\u00e9s dans les fibres nerveuses sensorielles de notre syst\u00e8me respiratoire. Dans ce cas, nous parlons sp\u00e9cifiquement des fibres nerveuses sensorielles de type C.<\/p>\n

De plus, TRPV1 est \u00e9galement exprim\u00e9 dans les cellules musculaires lisses, ainsi que dans les cellules endoth\u00e9liales vasculaires et les cellules inflammatoires du syst\u00e8me respiratoire.<\/p>\n

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R\u00e9cepteurs vanillo\u00efdes et syndrome du c\u00f4lon irritable<\/h2>\n

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Le syndrome du c\u00f4lon irritable est un trouble intestinal qui survient sans alt\u00e9ration structurelle ou biochimique<\/strong>. Il s’agit d’une maladie caract\u00e9ris\u00e9e par des douleurs abdominales, une distension abdominale, ainsi que des alt\u00e9rations des habitudes intestinales.<\/p>\n

Des modifications des caract\u00e9ristiques des selles sont \u00e9galement fr\u00e9quentes. Mais \u00e0 l’heure actuelle, la pathogen\u00e8se de ce syndrome n’est pas enti\u00e8rement claire. Les informations disponibles indiquent que l’hypersensibilit\u00e9 visc\u00e9rale est un facteur cl\u00e9 dans la g\u00e9n\u00e9ration de la douleur.<\/p>\n

Des recherches ont r\u00e9v\u00e9l\u00e9 que l’expression de TRPV1 dans les fibres nerveuses \u00e9tait significativement accrue dans les tissus du c\u00f4lon<\/strong> des personnes atteintes du syndrome du c\u00f4lon irritable. Il est int\u00e9ressant de noter que cette r\u00e9gulation positive est li\u00e9e \u00e0 l’intensit\u00e9 de la douleur abdominale.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”Ligne CTA” module_class=” et_pb_row_fullwidth” _builder_version=”4.8.2″ background_color=”#00a88d” width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/07\/receptores-vaniloides-pancreatitis.jpg” alt=”R\u00e9cepteurs vanillo\u00efdes pancr\u00e9atite” title_text=”R\u00e9cepteurs vanillo\u00efdes pancr\u00e9atite” force_fullwidth=”on” _builder_version=”4.9.7″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.8.2″ background_enable_color=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_cta button_url=”#top” _builder_version=”4.10.8″ header_font=”|800|||||||” header_text_color=”#ffffff” header_font_size=”35px” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” header_font_size_tablet=”25px” header_font_size_phone=”20px” header_font_size_last_edited=”on|desktop” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n

Pancr\u00e9atite<\/h3>\n

La pancr\u00e9atite se produit lorsqu’il y a une inflammation du pancr\u00e9as<\/strong>. C’est un organe qui a \u00e0 la fois des fonctions exocrines et endocrines. La synth\u00e8se, le stockage et la s\u00e9cr\u00e9tion normaux des enzymes digestives sont essentiels au maintien d’un pancr\u00e9as sain.<\/p>\n

Des \u00e9tudes indiquent que les r\u00e9cepteurs vanillo\u00efdes se trouvent dans les fibres nerveuses pr\u00e8s de l’acinus pancr\u00e9atique<\/strong>. Ce sont les cellules pr\u00e9sentes dans le pancr\u00e9as, qui sont responsables de la production du suc pancr\u00e9atique, utilis\u00e9 pour la digestion des aliments<\/a>.<\/p>\n

Ces recherches ont montr\u00e9 que l’expression et la fonction de TRPV1 sont r\u00e9gul\u00e9es positivement dans la r\u00e9duction de la douleur visc\u00e9rale. Des \u00e9tudes ant\u00e9rieures ont montr\u00e9 que les dommages inflammatoires peuvent lib\u00e9rer des agonistes TRPV1 endog\u00e8nes dans le pancr\u00e9as.<\/p>\n

On a \u00e9galement constat\u00e9 que l’activation du r\u00e9cepteur TRPV1<\/strong> est associ\u00e9e \u00e0 la production d’inflammation et de douleur pancr\u00e9atiques<\/strong>.<\/p>\n

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Hypertension art\u00e9rielle<\/h3>\n

Il s’agit d’une maladie caus\u00e9e par des interactions g\u00e9n\u00e9tiques et environnementales<\/strong>, qui produisent des changements dans la fonction et la structure du c\u0153ur et du syst\u00e8me cardiovasculaire.<\/p>\n

Des \u00e9tudes ont montr\u00e9 que les r\u00e9cepteurs vanillo\u00efdes sont fortement impliqu\u00e9s dans la d\u00e9tection des fluctuations de la pression art\u00e9rielle. On a constat\u00e9 que le r\u00e9cepteur TRPV1 \u00e9tait exprim\u00e9 sur les fibres nerveuses et terminales de la couche de tissu conjonctif de l’aorte ascendante<\/strong>, de la vo\u00fbte aortique, et sur les fibres aff\u00e9rentes des ganglions nodaux.<\/p>\n

En outre, ces r\u00e9cepteurs peuvent \u00eatre consid\u00e9r\u00e9s comme des m\u00e9canosenseurs intravasculaires capables de r\u00e9guler la pression sangu<\/a>ine en d\u00e9tectant les changements de pression m\u00e9canique.<\/p>\n

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Articles connexes<\/h4>\n

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Abonnez-vous \u00e0 notre newsletter<\/h2>\n

Abonnez-vous et b\u00e9n\u00e9ficiez d\u2019une r\u00e9duction de 10% sur votre achat. <\/p>\n

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boutique<\/h4>\n

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CBD \u00e0 5%<\/a><\/p>\n

[\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]CBD \u00e0 10%<\/a>[\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

CBD \u00e0 20%<\/a><\/p>\n

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Baume cicatrisant<\/a><\/p>\n

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Crema dolor muscular<\/a><\/p>\n

[\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.1″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

Cr\u00e8me pour les mains<\/a><\/p>\n

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Cr\u00e8me de nuit<\/a><\/p>\n

[\/et_pb_blurb][et_pb_button button_url=”https:\/\/higeacbd.com\/tienda” button_text=”Visitez la boutique” _builder_version=”4.13.1″ custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” custom_margin_phone=”||60px||false|false” custom_margin_last_edited=”off|tablet” custom_padding=”18px|0px|18px|0px|true|true” custom_padding_tablet=”14px||14px||true|true” custom_padding_phone=”12px||12px||true|true” custom_padding_last_edited=”on|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#00a88d” locked=”off” global_colors_info=”{}” button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#ffffff” box_shadow_color__hover_enabled=”off|hover” box_shadow_color__hover=”#e14a00″][\/et_pb_button][et_pb_button button_url=”https:\/\/higeacbd.com\/fr\/boutique\/huiles” button_text=”Huiles” _builder_version=”4.13.1″ _dynamic_attributes=”button_url” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” custom_margin_phone=”||60px||false|false” custom_margin_last_edited=”off|tablet” custom_padding=”1px|0px|1px|0px|true|true” custom_padding_tablet=”14px||14px||true|true” custom_padding_phone=”1px||1px||true|true” custom_padding_last_edited=”off|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#00a88d” locked=”off” global_colors_info=”{}” button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#ffffff” box_shadow_color__hover_enabled=”off|hover” box_shadow_color__hover=”#e14a00″][\/et_pb_button][et_pb_button button_url=”https:\/\/higeacbd.com\/fr\/boutique\/cremes” button_text=”Cr\u00e8mes” _builder_version=”4.13.1″ _dynamic_attributes=”button_url” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” custom_margin_phone=”||60px||false|false” custom_margin_last_edited=”off|tablet” custom_padding=”1px|0px|1px|0px|true|true” custom_padding_tablet=”14px||14px||true|true” custom_padding_phone=”1px||1px||true|true” custom_padding_last_edited=”off|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#00a88d” locked=”off” global_colors_info=”{}” button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#ffffff” box_shadow_color__hover_enabled=”off|hover” box_shadow_color__hover=”#e14a00″][\/et_pb_button][et_pb_blurb title=”Mon compte” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE0In19@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Plan de convivialit\u00e9” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE1NjE0In19@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Vente en gros CBD” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjUyMDEifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Vendredi noir” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjEyODY0In19@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.5.1″ background_color=”#00205c” custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop” global_colors_info=”{}”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#ffffff” header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”1.8em” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Guides<\/h4>\n

[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07-2.png” alt=”simboolo higea” title_text=”spice-shop-07″ _builder_version=”4.5.1″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb title=”Combattre l’anxi\u00e9t\u00e9” url=”https:\/\/higeacbd.com\/fr\/combattre-lanxiete” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Comment prendre de l\u2019huile de CBD” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjUzMiJ9fQ==@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Qu\u2019est-ce que la CDB” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjU4NyJ9fQ==@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Avantages cbd” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjY1OSJ9fQ==@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”CBD et CBDA” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE5NjgifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Meilleur CBD” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIxNDgifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”\u00c9tudes scientifiques” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTgifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Antid\u00e9presseurs” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjM3MTQxIn19@” use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop” global_colors_info=”{}”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#ffffff” header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”1.8em” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

En savoir plus<\/h4>\n

[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07-2.png” alt=”simboolo higea” title_text=”spice-shop-07″ _builder_version=”4.5.1″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb title=”Blog” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6Ijc3NyJ9fQ==@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Animaux de compagnie CBD” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE4OTgifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Cytokines” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE5OTkifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Terp\u00e8nes” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI3NDEifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Extraction de CBD” url=”https:\/\/higeacbd.com\/fr\/aceites\/methodes-dextraction-de-cbd” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Huiles porteuses” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIzNzcifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Qu\u2019est-ce que les flavono\u00efdes” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIyOTMifX0=@” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.13.0″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.4.9″ global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.4.4″ background_color=”#ffffff” custom_padding=”80px|60px|80px|60px|true|true” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#000000″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Avis juridique et politique de confidentialit\u00e9<\/h4>\n

[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png” alt=”simboolo higea” title_text=”simboolo higea” _builder_version=”4.5.1″ locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#000000″ icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

AVIS JURIDIQUE<\/a><\/p>\n

[\/et_pb_blurb][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#000000″ icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]CONFIDENTIALIT\u00c9 ET COOKIES<\/a>[\/et_pb_blurb][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#000000″ icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

POLITIQUE DE RETOUR<\/a><\/p>\n

[\/et_pb_blurb][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”V||divi||400″ icon_color=”#000000″ icon_placement=”left” _builder_version=”4.13.0″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]CONTACT<\/a>[\/et_pb_blurb][et_pb_text _builder_version=”4.6.5″ _module_preset=”default” text_font_size=”15px” global_colors_info=”{}”]pedidos@higeacbd.com<\/a>[\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/formas-de-pago.png” alt=”m\u00e9thodes de paiement” title_text=”m\u00e9thodes de paiement” _builder_version=”4.6.5″ _module_preset=”default” custom_margin=”10px||10px||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text admin_label=”DMCA protected” _builder_version=”4.6.5″ _module_preset=”default” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”] \"DMCA.com<\/a><\/p>\n