{"id":4744,"date":"2020-08-20T17:07:22","date_gmt":"2020-08-20T17:07:22","guid":{"rendered":"https:\/\/higeacbd.com\/cytokines\/"},"modified":"2021-11-12T11:12:11","modified_gmt":"2021-11-12T11:12:11","slug":"cytokines","status":"publish","type":"page","link":"https:\/\/higeacbd.com\/en\/cytokines","title":{"rendered":"Cytokines"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Anuncio superior” _builder_version=”4.9.4″ z_index=”999″ custom_margin=”0px||0px||true|false” custom_padding=”0px||0px||true|false” animation_direction=”top” custom_css_main_element=”position: relative;” global_module=”33910″ custom_css_main_element_last_edited=”on|desktop” custom_css_main_element_tablet=”position: relative;”][et_pb_row use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.9.0″ background_color=”#20a082″ background_color_gradient_direction=”90deg” width=”100%” max_width=”100%” custom_margin=”0px||0px||true|false” custom_padding=”0px||0px||true|false”][et_pb_column type=”4_4″ _builder_version=”4.0.6″ custom_css_main_element=”display:flex;||align-items: center;||justify-content: center;”][et_pb_blurb title=”Free shipping in Spain and Portugal!” use_icon=”on” font_icon=”%%379%%” icon_color=”#FFFFFF” icon_placement=”left” use_icon_font_size=”on” icon_font_size=”16px” _builder_version=”4.9.0″ header_text_color=”#ffffff” header_font_size=”16px” header_line_height=”1.3em” max_width_tablet=”” max_width_phone=”230px” max_width_last_edited=”on|phone” custom_padding=”10px||||false|false” animation_direction=”left” header_font_size_tablet=”” header_font_size_phone=”14px” header_font_size_last_edited=”on|phone” icon_font_size__hover_enabled=”off|desktop”][\/et_pb_blurb][et_pb_button button_url=”https:\/\/higeacbd.com\/tienda” button_text=”Buy CBD” _builder_version=”4.9.0″ custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#0b5b44″ button_bg_color_gradient_start=”#ff4ac2″ button_bg_color_gradient_end=”#ff4a9e” button_bg_color_gradient_direction=”90deg” button_border_width=”0px” button_border_radius=”20px” button_font=”|600|||||||” button_icon=”%%242%%” custom_margin=”|||20px|false|false” custom_margin_tablet=”” custom_margin_phone=”|||10px|false|false” custom_margin_last_edited=”on|desktop” custom_padding=”0px||0px||false|false” custom_padding_tablet=”” custom_padding_phone=”2px|8px|2px|8px|true|true” custom_padding_last_edited=”on|desktop” button_text_size_tablet=”” button_text_size_phone=”13px” button_text_size_last_edited=”on|phone”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Hero” _builder_version=”4.5.1″ background_color=”rgba(255,255,255,0.65)” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/marihuana-cbd.jpg” background_blend=”soft-light” custom_padding=”3vw||1vw|||”][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”What are cytokines” _builder_version=”4.5.1″ header_level=”h1″ header_font=”|800|||||||” header_font_size=”45px” header_line_height=”1.3em” body_font=”|800|||||||” body_text_color=”#000000″ body_font_size=”20px” body_line_height=”1.6em” use_background_color=”off” custom_button=”on” button_text_size=”14px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_width=”8px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” background_layout=”light” animation_direction=”bottom” header_font_size_tablet=”” header_font_size_phone=”50px” header_font_size_last_edited=”on|phone” button_text_color_hover=”#ffffff” button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”rgba(47,56,84,0.9)” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”rgba(47,56,84,0.9)” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n

We explain what cytokines<\/strong> are and their functions.<\/p>\n

[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Products” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”20px||11px||false|false”][et_pb_row _builder_version=”4.5.1″ custom_padding=”8px||17px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.6″ text_font=”|500|||||||” text_text_color=”#000000″ quote_font=”||||||||” header_font=”||||||||” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.4em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||12px|||”]<\/p>\n

Cytokines or cytokines<\/strong> are small proteins that make cells to communicate with each other, triggering different responses depending on what the body needs.<\/p>\n

These proteins are part of the innate immune system and are responsible for mediating between the cells that make up it as lymphoids, inflammatory and hematopoietic.<\/p>\n

Intercellular communication occurs by binding cytokines to specific receptors present in the cell membrane by activating certain genes that will generate a specific biological response.<\/p>\n

More simply, when an antigen element such as bacteria, viruses, or tumor cells enter the body, the cells activate and attack these elements to try to destroy them.<\/p>\n

If it is not possible, they will “call” other cells to help them and lash out against the agent causing the evil.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default” background_enable_color=”off”][et_pb_wc_images product=”205″ _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_wc_title product=”205″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” custom_margin=”||9px|||” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwNSJ9fQ==@” border_color_all=”#00a88d” border_width_bottom=”2px” border_color_bottom=”#00205c”][\/et_pb_wc_title][et_pb_wc_price product=”205″ _builder_version=”4.5.1″ _module_preset=”default” body_font_size=”16px” custom_margin=”||10px|||”][\/et_pb_wc_price][et_pb_wc_rating product=”205″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” body_font_size=”10px” custom_margin=”0em|0em|0.6em|0em|false|false” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwNSJ9fQ==@”][\/et_pb_wc_rating][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”2px||10px|||”]<\/p>\n

Higea CBD 5% oil helps you recover quickly from your sports workouts<\/p>\n

[\/et_pb_text][et_pb_wc_add_to_cart product=”205″ show_quantity=”off” _builder_version=”4.5.1″ _module_preset=”default” custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_color=”#00a88d” button_border_radius=”0px” button_icon=”%%114%%”][\/et_pb_wc_add_to_cart][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_wc_images product=”207″ _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_wc_title product=”207″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” custom_margin=”||9px|||” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwNyJ9fQ==@” border_color_all=”#00a88d” border_width_bottom=”2px” border_color_bottom=”#00205c”][\/et_pb_wc_title][et_pb_wc_price product=”207″ _builder_version=”4.5.1″ _module_preset=”default” body_font_size=”16px” custom_margin=”||10px|||”][\/et_pb_wc_price][et_pb_wc_rating product=”207″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” body_font_size=”10px” custom_margin=”0em|0em|0.6em|0em|false|false” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwNyJ9fQ==@”][\/et_pb_wc_rating][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”2px||10px|||”]<\/p>\n

Higea CBD at 10% is recommended to take before bed or reduce stress situations<\/p>\n

[\/et_pb_text][et_pb_wc_add_to_cart product=”207″ show_quantity=”off” _builder_version=”4.5.1″ _module_preset=”default” custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_color=”#00a88d” button_border_radius=”0px” button_icon=”%%114%%”][\/et_pb_wc_add_to_cart][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default” background_enable_color=”off”][et_pb_wc_images product=”208″ _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_wc_title product=”208″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” custom_margin=”||9px|||” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwOCJ9fQ==@” border_color_all=”#00a88d” border_width_bottom=”2px” border_color_bottom=”#00205c”][\/et_pb_wc_title][et_pb_wc_price product=”208″ _builder_version=”4.5.1″ _module_preset=”default” body_font_size=”16px” custom_margin=”||10px|||”][\/et_pb_wc_price][et_pb_wc_rating product=”208″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” body_font_size=”10px” custom_margin=”0em|0em|0.6em|0em|false|false” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwOCJ9fQ==@”][\/et_pb_wc_rating][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”2px||10px|||”]<\/p>\n

Higea CBD 20% is indicated for people with anxiety problems and ongoing ailments<\/p>\n

[\/et_pb_text][et_pb_wc_add_to_cart product=”208″ show_quantity=”off” _builder_version=”4.5.1″ _module_preset=”default” custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_color=”#00a88d” button_border_radius=”0px” button_icon=”%%114%%”][\/et_pb_wc_add_to_cart][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_wc_images product=”211″ _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_wc_title product=”211″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” custom_margin=”||9px|||” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIxMSJ9fQ==@” border_color_all=”#00a88d” border_width_bottom=”2px” border_color_bottom=”#00205c”][\/et_pb_wc_title][et_pb_wc_price product=”211″ _builder_version=”4.5.1″ _module_preset=”default” body_font_size=”16px” custom_margin=”||10px|||”][\/et_pb_wc_price][et_pb_wc_rating product=”211″ _builder_version=”4.5.1″ _dynamic_attributes=”link_option_url” _module_preset=”default” body_font_size=”10px” custom_margin=”0em|0em|0.6em|0em|false|false” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIxMSJ9fQ==@”][\/et_pb_wc_rating][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”2px||10px|||”]<\/p>\n

Higea CBD 30% is effective for people with chronic diseases, severe pains. It’s antiemetic<\/p>\n

[\/et_pb_text][et_pb_wc_add_to_cart product=”211″ show_quantity=”off” _builder_version=”4.5.1″ _module_preset=”default” custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_color=”#00a88d” button_border_radius=”0px” button_icon=”%%114%%”][\/et_pb_wc_add_to_cart][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.5.1″ custom_padding=”8px||17px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.6″ text_font=”|500|||||||” text_text_color=”#000000″ quote_font=”||||||||” header_font=”||||||||” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.4em” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||12px|||”]<\/p>\n

Depending on the type of cytokines and which cells you interact with, the message will be different.<\/strong><\/p>\n

They can emit signals to another immune cell to increase or decrease their enzyme production or to increase their effector functions and combat the disease.<\/p>\n

You can also instruct a cell to stop working and die.<\/p>\n

Cytokines are secreted by B and T lymphocytes (lymphin or lymphine), macrophages (monokines) and neutrophil granulocytes, among other cells that are also involved in getting the immune system up and running.<\/p>\n

This segregation occurs momentarily and is subject to a short period of time.<\/p>\n

There are different types of cytokines with multiple biological functions. Some may have the same structure but with different functions or simply have the ability to use different receivers.<\/p>\n

In fact, the same cytokine can have a specific function over a given cell, and have another function that is completely contrary to another.<\/p>\n

Due to their complexity, cytokines can be divided into several groups depending on their structure, receivers, or functionality. They bind to terpenes,<\/a> flavonoids<\/a> and CBD to create the so-called entourage effect.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px”][et_pb_row _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”28px|40px|18px|40px||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

Cytokines involved in the inflammatory response<\/h2>\n

As for the inflammatory response, cytokines can act in two totally opposite ways.<\/strong><\/p>\n

On the one hand, favoring the development of said inflammatory response, so-called pro-inflammatory cytokines,<\/strong>and on the other, eliminating inflammation, immunosuppressive cytokines.<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”40px||40px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.4.4″ custom_padding=”||18px|||” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.4.4″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/citocinas.jpg” alt=”Cytokines” title_text=”Cytokines” _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

Pro-inflammatory cytokines<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n

They are activated when the cells involved in the immune response come into contact with a pathogen.<\/p>\n

What they do is activate an inflammatory response in cells, quite the opposite of anti-inflammatory cytokines.<\/p>\n

They are mainly segregated by monocytes, macrophages and lymphocytes.<\/strong><\/p>\n

The most important are the following:<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.4.4″ custom_padding=”||18px|||” locked=”off”][et_pb_column type=”1_2″ _builder_version=”4.4.4″][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

Interleukin 1 (IL-1)<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.2″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n

Its main function is to regulate the inflammatory response.<\/p>\n

It belongs to the group of proteins related to the production of leukocytes (white blood cells) and other cells of the body.<\/p>\n

There are two forms, interleukin alfa (IL-1 alfa) and interleukin beta (IL-1 beta). Both act on the same receiver.<\/p>\n

The main producers of IL-1 are macrophages, although it is also synthesized by keratinocytes, microglia, endothelial cells, fibroblasts and epithelial cells.<\/p>\n

They occur in large quantities when the body suffers an infection or injury.<\/p>\n

Its pro-inflammatory effects are the result of the release of histamine by mast cells, causing vasodilation and inflammation of the affected area.<\/p>\n

Another effect is fever, as a result of the release of prostaglandins. It also acts on the central nervous system, causing sleep and anorexia<\/a> typical of infectious processes.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

Tumor necrosis factor (TNF)<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n

They are cytokines produced by monocytes, macrophages, T and B lymphocytes, natural killer cells (NK), fibroblasts and mast cells.<\/p>\n

TNF, along with IL-1, is involved in the emergence of fever, cachexia (state associated with weight loss, anemia or anorexia) and sleep, symptoms that usually manifest in an infectious picture.<\/p>\n

Tumor necrosis factor has the ability to induce death of some types of tumor cells, as well as increased antitumor immune response.<\/p>\n

These are therefore cytokines that mediate in the processes of inflammation and cell death.<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.4.4″ custom_padding=”||18px|||” locked=”off”][et_pb_column type=”1_2″ _builder_version=”4.4.4″][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

Interferons (IFN)<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n

They are cytokines that the body manufactures to cope with the presence of different pathogens.<\/p>\n

They are classified into two types:<\/p>\n

    \n
  1. Type I<\/strong> consisting of IFN-alpha<\/strong> and IFN-beta,<\/strong>which are characterized by their antiviral and antiproliferative properties.<\/li>\n
  2. Type II<\/strong> formed by IFN-gamma<\/strong> which has an immunomodulatory effect.<\/li>\n<\/ol>\n

    IFN-alpha is a protein produced by macrophages and B lymphocytes primarily.<\/p>\n

    It is used in the treatment of some cancers due to its power to increase the ability of certain immune cells and attack cancer cells.<\/p>\n

    IFN-beta is produced by fibroblasts and epithelial cells.<\/p>\n

    IFN-gamma is secreted by activated T cells and NK cells.<\/p>\n

    Its production is increased by the action of other cytokines which, in turn, increase the adverse hemodynamic effects of these cytokines in sepsis and septic shock.<\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

    Colony Stimulating Factors (CSF)<\/h3>\n

    [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n

    They are growth factors and their functions are associated with inflammation and the production of other cytokines.<\/p>\n

    There are three types of CSF factors:<\/strong><\/p>\n

      \n
    1. GM-CSF<\/strong>: Cytokine belonging to the group of glucoproteins that increase the production of white blood cells. It is created by T cells, monocytes, endothelial cells and fibroblasts. It stimulates the formation of granulocytes and macrophages to a greater extent and to a lesser extent of eosinophils.<\/li>\n
    2. G-CSF<\/strong>: Glycoprotein created by monocytes, endothelial cells and epithelial cells. It is involved inducing the bone marrow to make more white blood cells.<\/li>\n
    3. M-CSF<\/strong>: Glycoprotein produced by monocytes, fibroblasts and endothelial cells. It is involved by stimulating the survival, proliferation and differentiation of hematopoietic cells to macrophages or other related cells.<\/li>\n<\/ol>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.4.4″ custom_padding=”||18px|||” locked=”off”][et_pb_column type=”4_4″ _builder_version=”4.4.4″][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”25px” custom_margin=”||12px||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

      Chemokine or chemokine<\/h3>\n

      [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n

      They are thus defined to a very specific group of cytokines, which stimulate the mobility of immune system cells to a target.<\/p>\n

      Chemokin belongs to the class of molecules called chemoatrayants, capable of attracting and directing other cells from one organ to another.<\/p>\n

      There are several types of chemokine including interleukins, interferons, tumor necrosis factors, and growth factors.<\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px”][et_pb_row _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”46px|40px|15px|40px||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

      Immunosuppressive cytokines<\/h2>\n

      It corresponds to a group of cytokines that inhibit cell growth and suppress or block the secretion of other cytokines.<\/p>\n

      Cytokines that are part of this group:<\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”29px|40px|12px|40px||”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”30px” z_index=”2″ background_layout=”dark” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”off|desktop” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

      Interleukin 4 (IL-4)<\/h3>\n

      It has an anti-inflammatory effect, as it reduces the production of the different inflammatory mediators of macrophages and blocks the action of CYTOkine IL-1.<\/p>\n

      At the same time, it develops a humorous immune response to promote the induction of T cells into Th2-type cells.<\/p>\n

      It is related to the proliferation of B lymphocytes, mast cells and T lymphocytes.<\/p>\n

      [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”30px” z_index=”2″ background_layout=”dark” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”off|desktop” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

      Interleukin 10 (IL-10)<\/h3>\n

      It is the most important anti-inflammatory cytokine in the immune response, acting that it exerts through inhibition of other cytokines such as TNF-alpha, IL-2, IL-3, IL-12 and GM-CSF among others.<\/p>\n

      It is segregated proportionally to the intensity of the inflammatory stimulus.<\/p>\n

      IL-10 exerts its anti-inflammatory action on monocytes, macrophages, neutrophils and T cells.<\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”19px|40px|41px|40px||”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”30px” z_index=”2″ background_layout=”dark” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”off|desktop” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

      Interleukin 13 (IL-13)<\/h3>\n

      IL-13 is a cytokine produced by T cells. It is consistent with IL-2 in the regulation of IFN-gamma synthesis.<\/p>\n

      In addition, it inhibits, together with IL-4 and IL-10, the production of inflammatory cytokines.<\/p>\n

      [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” header_3_font=”|700|||||||” header_3_font_size=”30px” z_index=”2″ background_layout=”dark” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”off|desktop” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone”]<\/p>\n

      Growth Transformer Factor (TGF)<\/h3>\n

      They are of two types: alpha and beta, and have no structural or functional similarity between them.<\/p>\n

      Various types of cells such as lymphocytes, macrophages and dendritic cells synthesize TGF-beta.<\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.5.1″ custom_margin=”|auto|-2px|auto||” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.5.1″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/citocinas-proinflamatorias-y-antiinflamatorias.jpg” alt=”pro-inflammatory and anti-inflammatory cytokines” title_text=”Pro-inflammatory and anti-inflammatory cytokines” align=”center” _builder_version=”4.5.1″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.4.4″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”off|desktop”]<\/p>\n

      Cytokines involved in the immune response<\/h2>\n

      [\/et_pb_text][et_pb_text _builder_version=”4.9.2″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off”]<\/p>\n

      As far as the immune response is concerned, cytokines act in an innate manner,<\/strong>that is, immediately and not specifically, or in an adaptive way.<\/strong><\/p>\n

      This is because they recognize the antigen and create an immunological memory<\/a> that lasts even if the pathogen has already been eliminated.<\/p>\n

      Cytokines involved in the innate immune response<\/h2>\n

      This group includes cytokines produced by mainly activated monocytes and macrophages immediately upon contact with the pathogen.<\/p>\n

      The main cytokines that make up this group are IL-1, TNF-alpha, IL-6 and IFN-gamma participants in the inflammatory response, and IL-10 which has an immunosuppressive action.<\/p>\n

      In addition to these cytokines, innate immune response also involves others such as IL-12 and IL-18.<\/strong><\/p>\n

      The most important action of these two cytokines is to be potent inducers of IFN-gamma<\/strong>:<\/p>\n

      Interleukin 12 (IL-12)<\/h3>\n

      They are essential for a response sequence involving macrophages, NK lymphocytes and T cells.<\/p>\n

      IL-12 increases the onset of cytotoxic T cells, which are a type of immune cells that can eradicate cancer cells and virus-infected cells.<\/p>\n

      Interleukin 18 (IL-18)<\/h3>\n

      It has the same joint action as IL-12 with respect to the production of IFN-gamma in T cells and natural killer cells.<\/p>\n

      Interleukin 18 increases IL-2 production, participates in the regulation of Th1 type response and may decrease IL-10 production.<\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.5.1″ background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/que-enfermedades-cura-el-cbd.jpg” overflow-x=”hidden” overflow-y=”hidden” custom_padding=”0px||0px||true|false”][et_pb_row column_structure=”3_5,2_5″ make_equal=”on” _builder_version=”4.5.1″ width_tablet=”100%” width_phone=”” width_last_edited=”on|tablet” custom_padding=”0px||0px||true|false” box_shadow_style=”preset4″ box_shadow_horizontal=”-30vw” box_shadow_vertical=”0px” box_shadow_color=”#00a88d” box_shadow_horizontal_tablet=”0vw” box_shadow_horizontal_phone=”” box_shadow_horizontal_last_edited=”on|tablet”][et_pb_column type=”3_5″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”3vh|30px|3vh||true|false” custom_padding_tablet=”10%|10%|10%|10%|true|true” custom_padding_phone=”||||false|true” custom_padding_last_edited=”on|phone”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07.png” _builder_version=”4.4.4″ custom_margin=”50px||||false|false” custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off”][\/et_pb_image][et_pb_text _builder_version=”4.5.1″ header_font=”|800|||||||” header_font_size=”100px” header_line_height=”1.2em” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” background_layout=”dark” header_font_size_tablet=”40px” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone”]<\/p>\n

      Cytokines involved in adaptive immune response<\/h2>\n

      [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_text_color=”#ffffff” link_text_color=”#000000″ background_layout=”dark” text_font_size_tablet=”14px” text_font_size_phone=”” text_font_size_last_edited=”on|phone”]<\/p>\n

      Activation of T and B lymphocytes require the participation of certain cytokines, such as interleukin 2 (IL-2), 15 (IL-15) and 16 (IL-16).<\/p>\n

      [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.5.1″ custom_padding=”20%|0px|20%||true|false” custom_padding_tablet=”|10%||10%|false|true” custom_padding_phone=”||||false|false” custom_padding_last_edited=”on|phone”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”35px|40px|41px|40px||” box_shadow_style=”preset4″ box_shadow_horizontal=”-1044px” box_shadow_vertical=”0px” box_shadow_color=”#00a88d”][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_3_font=”Montserrat|800|||||||” header_3_font_size=”20px” header_3_line_height=”1.2em” text_orientation=”center” background_layout=”dark” header_3_font_size_tablet=”18px” header_3_font_size_phone=”16px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n

      Interleukin 2 (IL-2)<\/h3>\n

      Created by Th1 lymphocytes, it causes the growth and differentiation of the response of T and B lymphocytes.<\/p>\n

      IL-2 interleukin is necessary for the establishment of cellular immune memory and the recognition of external autoantigens and antigens.<\/p>\n

      It plays a key role in the development of both humoral and cellular chronic inflammatory responses.<\/strong><\/p>\n

      [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_3_font=”Montserrat|800|||||||” header_3_font_size=”20px” header_3_line_height=”1.2em” text_orientation=”center” background_layout=”dark” header_3_font_size_tablet=”18px” header_3_font_size_phone=”16px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n

      Interleukin 15 (IL-15)<\/h3>\n

      It has a biological activity similar to IL-2, although they differ in the cells on which they act.<\/p>\n

      IL-15 is segregated by a wide variety of cells, including monocytes, epithelial cells, myocytes, and hepatocytes.<\/p>\n

      [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_3_font=”Montserrat|800|||||||” header_3_font_size=”20px” header_3_line_height=”1.2em” text_orientation=”center” background_layout=”dark” header_3_font_size_tablet=”18px” header_3_font_size_phone=”16px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n

      Interleukin 16 (IL-16)<\/h3>\n

      IL-16 cytokine is produced by CD8 T lymphocytes in response to serotonin or histamine stimulation.<\/p>\n

      It works as a chemical-attractant and as a modulator of T-cell activation.<\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”36px|0px|0px|0px||”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.5.1″][et_pb_column type=”1_2″ _builder_version=”4.5.1″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/citoquinas-proinflamatorias.jpg” alt=”pro-inflammatory cytokines” title_text=”Pro-inflammatory cytokines” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.5.1″ animation_style=”slide” animation_direction=”right” animation_intensity_slide=”5%”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” text_font=”||||||||” text_font_size=”16px” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em”]<\/p>\n

      Other interleukins or interleukins<\/h2>\n

      [\/et_pb_text][et_pb_text _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n

      Interleukin 3 (IL-3)<\/h3>\n

      It is primarily created by Th2 lymphocytes and interact in the regulation of hematopoiesis by controlling the production, differentiation and function of granulocytes and macrophages.<\/p>\n

      Interleukin 5 (IL-5)<\/h3>\n

      Produced by T cells and mast cells, it stimulates the growth and proliferation of eosinophils, playing a very important role in diseases associated with increasing their levels.<\/p>\n

      Interleukin 6 (IL-6)<\/h3>\n

      Segregated by activated monocyte-macrophages, activated T and B lymphocytes, endothelial cells and fibroblasts.<\/p>\n

      IL-6 has both anti-inflammatory properties as it has a powerful ability to induce the release of acute phase proteins that have a beneficial effect on sepsis and septic shock, as well as pro-inflammatory.<\/p>\n

       <\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”|0px|0px|0px||” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta button_url=”#top” _builder_version=”4.5.1″ header_level=”h3″ header_font=”|800|||||||” header_font_size=”22px” header_line_height=”1.4em” body_font=”|500|||||||” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” background_layout=”light” max_width=”80%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”right” custom_padding=”5%|10%|0px|10%|false|true” header_font_size_last_edited=”off|desktop” button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n

      Interleukin 7 (IL-7)<\/h3>\n

      Stimulates the development of B and T lymphocyte precursor cells.<\/p>\n

      IL-7 has antitumor activity by increasing the production of cytotoxic T cells and NK cells.<\/p>\n

      Produced by keratinocytes, dendritic cells, hepatocytes, neurons and epithelial cells.<\/p>\n

      Interleukin 8 (IL-8)<\/h3>\n

      It is created by monocytes, macrophages, fibroblasts, keratinocytes and endothelial cells.<\/p>\n

      Its main function is to attract virgin and neutrophil lymphocytes as well as mobilize, activate and cause neutrophil degranulation.<\/p>\n

      It stimulates angiogenesis and the formation of new blood vessels from pre-existing ones.<\/p>\n

      Interleukin 9 (IL-9)<\/h3>\n

      It is a glycoprotein with mitogenic capacity and to induce T cell proliferation.<\/p>\n

      Interleukin 11 (IL-11)<\/h3>\n

      It is produced by the stroma cells of the bone marrow and by the mesenchymatic cells.<\/p>\n

      It acts on hematopoietic cells, intestinal epithelial cells and liver cells.<\/p>\n

      However, it has little effect on lymphocytes.<\/strong><\/p>\n

      Interleukin 17 (IL-17)<\/h3>\n

      It is a glycoprotein produced by stimulated CD4+ T cells.<\/p>\n

      It is able to stimulate the secretion of IL-6, IL-8 and G-CSF by epithelial cells, endothelial cells and fibroblasts.<\/p>\n

      [\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/citoquinas-alimentos.jpg” alt=”food cytokines” title_text=”Food cytokines” _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_color_gradient_direction=”90deg” background_enable_image=”off” background_position=”bottom_center” custom_padding=”0%||0%||true|false”][et_pb_row custom_padding_last_edited=”on|desktop” _builder_version=”4.5.1″ use_background_color_gradient=”on” background_color_gradient_start=”rgba(0,0,0,0.2)” background_color_gradient_end=”rgba(0,0,0,0.2)” background_color_gradient_overlays_image=”on” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cbd-medicinal.jpg” width=”100%” max_width=”none” custom_padding=”7%|5%|7%|5%|true|true” custom_padding_tablet=”5%|10%|5%|10%|true|true” custom_padding_phone=””][et_pb_column type=”4_4″ _builder_version=”4.4.4″][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07.png” align=”center” _builder_version=”4.4.8″ locked=”off”][\/et_pb_image][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800||on|||||” text_font_size=”18px” text_letter_spacing=”2px” header_font=”|800|||||||” header_font_size=”100px” header_line_height=”1.2em” header_3_font=”|800||on|||||” header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|800|||||||” header_4_font_size=”100px” text_orientation=”center” background_layout=”dark” text_font_size_tablet=”18px” text_font_size_phone=”” text_font_size_last_edited=”on|phone” header_font_size_tablet=”40px” header_font_size_phone=”30px” header_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|desktop” header_4_font_size_tablet=”40px” header_4_font_size_phone=”30px” header_4_font_size_last_edited=”on|phone”]<\/p>\n

      All the information on cytokines and cytokines<\/p>\n

       <\/p>\n

      Know what you’re consuming<\/h4>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.5.1″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.5.1″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_enable_image=”off” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/tipos-de-interleucinas.jpg” alt=”types of interleukins” title_text=”Types of interleukins” force_fullwidth=”on” _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_cta title=”Anti-inflammatory cytokines” button_url=”#top” _builder_version=”4.5.1″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n

      The most important anti-inflammatory cytokines are considered to be IL- 10, IL- 4, IL-6, IL-13,FEC-GM and interferon alfa (IFN-alpha).<\/strong><\/p>\n

      They have the ability to inhibit the release of pro-inflammatory cytokines and to induce the production of the receptor antagonist IL-1 and the release of the soluble receptor of the FNT.<\/p>\n

      Now that you know what cytokines are, you know better how the cellular world works and, ultimately, anyone’s body.<\/p>\n

      [\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Subscribe” _builder_version=”4.9.4″ use_background_color_gradient=”on” background_color_gradient_start=”#f3f3f1″ background_color_gradient_end=”rgba(255,255,255,0)” background_color_gradient_end_position=”30%” background_color_gradient_overlays_image=”on” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/aceite-de-cannabis-cbd.jpg” custom_padding=”100px|0px|30vw|0px” animation_direction=”bottom” saved_tabs=”all”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ text_font=”|500|||||||” text_text_color=”rgba(47,56,84,0.5)” text_font_size=”16px” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”|700|||||||” header_2_font_size=”50px” header_2_line_height=”1.3em” text_orientation=”center” max_width=”700px” module_alignment=”center”]<\/p>\n

      Subscribe to our newsletter<\/h2>\n

      Subscribe and receive a 10% discount on your purchase. <\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_2,1_4″ _builder_version=”3.25″ custom_padding=”19px|||||”][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_signup mailchimp_list=”higeacbd|5b4d14cf0e” first_name_field=”off” last_name_field=”off” _builder_version=”4.5.1″ header_font=”||||||||” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”89px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” border_radii_fields=”on|30px|30px|30px|30px” border_width_all_fields=”1px” border_color_all_fields=”rgba(47,56,84,0.2)” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_signup][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cannabis-medicinal.jpg” background_size=”contain” background_position=”bottom_center” global_module=”452″ saved_tabs=”all” locked=”off”][et_pb_row column_structure=”1_3,1_3,1_3″ make_equal=”on” _builder_version=”4.5.1″][et_pb_column type=”1_3″ _builder_version=”4.5.1″ background_color=”#000000″ custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#00a88d” header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”1.8em” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n

      Store<\/h4>\n

      [\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png” alt=”liver symbol” title_text=”liver symbol” _builder_version=”4.5.1″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off”][\/et_pb_image][et_pb_blurb use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop”]<\/p>\n

      5% CBD<\/a><\/p>\n

      [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop”]10% CBD<\/a>[\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop”]<\/p>\n

      20% CBD<\/a><\/p>\n

      [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop”]30% CBD<\/a>[\/et_pb_blurb][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjExIn19@” button_text=”Visit the shop” _builder_version=”4.9.4″ _dynamic_attributes=”button_url” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” custom_margin_phone=”||60px||false|false” custom_margin_last_edited=”off|tablet” custom_padding=”18px|0px|18px|0px|true|true” custom_padding_tablet=”14px||14px||true|true” custom_padding_phone=”12px||12px||true|true” custom_padding_last_edited=”on|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style=”preset4″ box_shadow_horizontal=”0px” box_shadow_vertical=”2px” box_shadow_color=”#00a88d” locked=”off” button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#ffffff” box_shadow_color__hover_enabled=”off|hover” box_shadow_color__hover=”#e14a00″][\/et_pb_button][et_pb_blurb title=”My account” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE0In19@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Friendly Plan” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE1NjE0In19@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Wholesale CBD” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjUyMDEifX0=@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Black Friday” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjEyODY0In19@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.5.1″ background_color=”#00205c” custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#ffffff” header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”1.8em” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n

      Guides<\/h4>\n

      [\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07.png” alt=”liver symbol” title_text=”spice-shop-07″ _builder_version=”4.5.1″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off”][\/et_pb_image][et_pb_blurb title=”Combat Anxiety” url=”https:\/\/higeacbd.com\/en\/combat-anxiety” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”How to take CBD oil” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjUzMiJ9fQ==@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”What is CBD” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjU4NyJ9fQ==@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”CBD Benefits” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjY1OSJ9fQ==@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”CBD and CBDA” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE5NjgifX0=@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Best CBD” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIxNDgifX0=@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Scientific studies” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTgifX0=@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Antidepressants” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjM3MTQxIn19@” use_icon=”on” font_icon=”%%53%%” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.5.1″ background_color=”#00a88d” custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#ffffff” header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”1.8em” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n

      Find out more<\/h4>\n

      [\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-07.png” alt=”liver symbol” title_text=”spice-shop-07″ _builder_version=”4.5.1″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off”][\/et_pb_image][et_pb_blurb title=”Blog” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6Ijc3NyJ9fQ==@” use_icon=”on” font_icon=”%%53%%” icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”CBD Pets” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE4OTgifX0=@” use_icon=”on” font_icon=”%%53%%” icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Cytokines” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE5OTkifX0=@” use_icon=”on” font_icon=”%%53%%” icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Terpenes” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI3NDEifX0=@” use_icon=”on” font_icon=”%%53%%” icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”CBD extraction” url=”https:\/\/higeacbd.com\/en\/oils\/cbd-extraction-methods” use_icon=”on” font_icon=”%%53%%” icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”Carrier oils” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIzNzcifX0=@” use_icon=”on” font_icon=”%%53%%” icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][et_pb_blurb title=”What are flavonoids” url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIyOTMifX0=@” use_icon=”on” font_icon=”%%53%%” icon_color=”#ffffff” icon_placement=”left” _builder_version=”4.9.4″ _dynamic_attributes=”url” header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.4.9″][et_pb_column type=”1_2″ _builder_version=”4.4.4″ background_color=”#ffffff” custom_padding=”80px|60px|80px|60px|true|true” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”on|tablet”][et_pb_text _builder_version=”4.5.1″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#000000″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n

      Legal notice and privacy policy<\/h4>\n

      [\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png” alt=”liver symbol” title_text=”liver symbol” _builder_version=”4.5.1″ locked=”off”][\/et_pb_image][et_pb_blurb url_new_window=”on” use_icon=”on” font_icon=”%%53%%” icon_color=”#000000″ icon_placement=”left” _builder_version=”4.9.4″ header_font=”|700||on|||||” header_text_color=”#000000″ header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” link_option_url_new_window=”on” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|desktop” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop”]<\/p>\n