[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Products” _builder_version=”4.16″ background_color=”#f3f3f1″ custom_padding=”20px||11px||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”8px||17px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.2″ text_font=”|500|||||||” text_text_color=”#000000″ quote_font=”||||||||” header_font=”||||||||” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.4em” text_orientation=”center” max_width=”80%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” custom_margin=”||12px|||” global_colors_info=”{}”]<\/p>\n
Obwohl Menschen mit Depressionen schon seit Jahrzehnten Antidepressiva einnehmen, hatte die Wissenschaft noch nicht wirklich herausgefunden, wie sie biologisch wirken – bis jetzt. Eine neue Studie zu diesem Thema stellt alles in Frage, was bisher \u00fcber die Wirkungsweise von Antidepressiva<\/strong> bekannt war.<\/p>\n Diese neuen Forschungsergebnisse deuten darauf hin, dass selektive Serotonin-Wiederaufnahmehemmer(SSRIs), die langsam wirkenden Medikamente zur Behandlung von Depressionen, und das schnell wirkende Ketamin direkt mit einem Rezeptor f\u00fcr den Brain-Derived Neurotrophic Factor(BDNF) zusammenwirken. Dadurch f\u00f6rdern sie die neuronale Plastizit\u00e4t, was wiederum Depressionen lindert, allerdings ohne den Einsatz von Serotonin oder Glutamat.<\/p>\n Hier sehen wir uns die Ergebnisse dieser neuen Studie zur Wirkungsweise von Antidepressiva an. Wir werden auch ein wenig \u00fcber die Verwendung von CBD Cannabidiol und seine antidepressiven Eigenschaften<\/strong> sprechen.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Produkte” _builder_version=”4.7.7″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_module=”16824″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_shop type=”best_selling” posts_number=”8″ show_pagination=”on” module_class=”custom-shop” _builder_version=”4.16″ _module_preset=”default” title_font=”|700|||||||” custom_margin=”||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][\/et_pb_shop][et_pb_signup mailchimp_list=”higeacbd|5b4d14cf0e” first_name_field=”off” last_name_field=”off” title=”Abonnieren und erhalten Sie 10% Rabatt” disabled_on=”off|off|off” _builder_version=”4.16″ header_level=”h4″ header_font=”|800|||||||” header_text_align=”center” header_text_color=”#000000″ header_font_size=”35px” header_line_height=”1.2em” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#00a88d” button_bg_color=”rgba(0,0,0,0)” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”2px” button_font=”|700||on|||||” button_use_icon=”off” button_custom_padding=”18px|0px|18px|0px|true|true” button_custom_padding_tablet=”14px||14px||true|true” button_custom_padding_phone=”12px||12px||true|true” button_custom_padding_last_edited=”on|phone” background_layout=”light” header_font_size_tablet=”25px” header_font_size_phone=”20px” header_font_size_last_edited=”on|desktop” button_text_size_tablet=”14px” button_text_size_phone=”12px” button_text_size_last_edited=”on|phone” box_shadow_style_button=”preset4″ box_shadow_horizontal_button=”0px” box_shadow_vertical_button=”2px” box_shadow_color_button=”#00a88d” global_colors_info=”{}” button_text_color__hover=”#28221d” button_text_color__hover_enabled=”on|hover” box_shadow_color_button__hover=”#000000″ box_shadow_color_button__hover_enabled=”on|desktop”][\/et_pb_signup][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”28px|40px|18px|40px||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.4″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” hover_enabled=”0″ header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n Die Forschung, \u00fcber die wir hier sprechen, ist eine internationale Studie <\/a>, die in der Zeitschrift Cell ver\u00f6ffentlicht wurde<\/a> und von zwei Neurowissenschaftlern namens Eero Castr\u00e9n<\/strong> und Plino Cassaroto<\/strong> geleitet wird. Sie wurde am Zentrum f\u00fcr Neurowissenschaften der Universit\u00e4t Helsinki in Zusammenarbeit mit der Abteilung f\u00fcr Physik durchgef\u00fchrt.<\/p>\n Der Zweck der Forschung war es, festzustellen, wie Antidepressiva mit einem BDNF-Rezeptor, bekannt als TrkB, interagieren<\/strong>. Im Einzelnen wurden die folgenden Medikamente untersucht:<\/p>\n Urspr\u00fcnglich dachte man, dass die Wirkungen von SSRI-Medikamenten und die Wirkungen von trizyklischen Antidepressiva<\/strong> von ihrer eigenen F\u00e4higkeit herr\u00fchren, mehr Serotonin und Noradrenalin im Gehirn zu halten, indem sie deren Spiegel im synaptischen Spalt erh\u00f6hen. In \u00e4hnlicher Weise wurde angenommen, dass die antidepressive Wirkung von Ketamin auf die Hemmung von Glutamatrezeptoren abzielt.<\/p>\n Alle drei<\/strong> in der Studie getesteten Antidepressiva<\/strong> interagieren mit dem TrkB-Rezeptor<\/strong>. Allerdings taten sie dies, ohne andere Neurotransmitter wie Serotonin, Noradrenalin oder Glutamat zu erh\u00f6hen oder zu hemmen.<\/p>\n Es ist erw\u00e4hnenswert, dass andere Forschungen bereits den Zusammenhang zwischen Antidepressiva und der Erh\u00f6hung neurotropher Faktoren festgestellt haben. Dies ist der Fall bei BDNF (brain-derived neurotrophic factor), der eine entscheidende Rolle bei der Regulation der Neuroplastizit\u00e4t spielt<\/strong>.<\/p>\n Die Forscher dachten jedoch, dass Antidepressiva indirekt \u00fcber Glutamat- und Serotoninrezeptoren auf BDNF wirken. Die Ergebnisse dieser Forschung haben das Potenzial, revolution\u00e4r zu sein. Sie zeigen, dass Antidepressiva tats\u00e4chlich direkt an BDNF-Rezeptoren binden<\/strong>.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.16″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”40px||40px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ custom_padding=”||18px|||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/como-funcionan-los-antidepresivos.jpg” alt=”wie Antidepressiva wirken” title_text=”wie Antidepressiva wirken” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.19.4″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n Seit zwei Jahrzehnten wissen Wissenschaftler, dass antidepressive Medikamente und aerobes Training die neuronale Plastizit\u00e4t und das Wachstum neuer Neuronen f\u00f6rdern. Es gibt auch Forschungen zu Bewegung und depressiven St\u00f6rungen<\/a>, bei denen der Zusammenhang zwischen einer durch Bewegung induzierten BDNF-Erh\u00f6hung und einem geringeren Risiko f\u00fcr eine schwere depressive St\u00f6rung<\/strong> untersucht wurde.<\/p>\n Dar\u00fcber hinaus haben sich andere Forschungen darauf konzentriert, herauszufinden, wie die Wirksamkeit von Antidepressiva mit BDNF zusammenh\u00e4ngen k\u00f6nnte. Die Forscher haben auch herausgefunden, wie ein molekularer Weg, der mit dem Aktivatorprotein 1 zusammenh\u00e4ngt, eine Kettenreaktion erm\u00f6glicht, die mehrere Gene aktiviert, die wiederum die neuronale Plastizit\u00e4t f\u00f6rdern.<\/p>\n Dies erm\u00f6glicht dem Gehirn, die neurologischen Sch\u00e4den, die normalerweise mit Depressionen einhergehen, r\u00fcckg\u00e4ngig zu machen. Das Interessante daran ist, dass nach zwei bis drei Wochen die regenerativen Effekte dieser Ver\u00e4nderungen zu sehen und zu sp\u00fcren<\/strong> sind. Studien haben dazu beigetragen, zu erkl\u00e4ren, warum SSRI-Medikamente bis zu 14 Tage brauchen, um aktiv zu werden.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”46px|40px|41px|40px||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n Fr\u00fchere Untersuchungen haben gezeigt, dass Antidepressiva bei einer therapeutischen Behandlung mit selektiven Serotonin-Wiederaufnahmehemmern (SSRI) allm\u00e4hlich eine hohe Konzentration im Gehirn<\/strong> erreichen , um sich an den TrkB-Rezeptor zu binden<\/strong>. Im Gegensatz dazu erreichen Ketamin und Esketamin, intraven\u00f6s verabreicht, innerhalb von Minuten den f\u00fcr die Bindung von Trkb erforderlichen Spiegel.<\/p>\n Den Forschern zufolge k\u00f6nnte der Unterschied im Wirkungseintritt von SSRIs und Ketamin das Ergebnis ihrer unterschiedlichen F\u00e4higkeit sein, die f\u00fcr die Bindung an den TrkB-Rezeptor im Gehirn erforderliche Konzentration zu erreichen. Es sollte auch gesagt werden, dass Ketamin normalerweise als Narkosemittel verwendet wurde, aber jetzt wird es zunehmend als Antidepressivum eingesetzt.<\/p>\n Obwohl SSRI-Medikamente viel st\u00e4rker an das Serotonin-Transporter-Protein als an TrkB binden, erfolgt die Bindung von Ketamin an den Glutamat-Rezeptor und TrkB bei \u00e4hnlichen Medikamentenkonzentrationen.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.16″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ custom_margin=”|auto|-2px|auto||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/colesterol-y-antidepresivos.jpg” alt=”Cholesterin und Antidepressiva” title_text=”Cholesterin und Antidepressiva” align=”center” _builder_version=”4.16″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n Der genaue Ort der Antidepressivabindung in der Transmembranregion von TrkB wurde durch molekulare Modellierung identifiziert. Diese Modellierung wurde von einer Gruppe von Forschern des Fachbereichs Physik der Universit\u00e4t Helsinki unter der Leitung von Professor Ilpo Vattuainen durchgef\u00fchrt. Um die Stelle zu verifizieren, f\u00fchrten die Wissenschaftler Studien zur biochemischen Bindung und zu in den TrkB-Rezeptor eingebrachten Mutationen durch.<\/p>\n Ein weiterer relevanter Aspekt, den das Molecular Modelling gezeigt hat, ist, dass die Struktur von TrkB empfindlich auf die Konzentration von Cholesterin in der Zellmembran reagiert<\/strong>. Dies ist wichtig, da sich TrkB in Membrankompartimente bewegt, die bekannterma\u00dfen eine reiche Quelle f\u00fcr Cholesterin sind, wie z. B. synaptische Membranen. Die Bindung von TrkB an das Antidepressivum stabilisiert Dimere, das sind Strukturen, die aus zwei TrkB-Rezeptoren bestehen.<\/p>\n Wenn dies geschieht, wird die Verdr\u00e4ngung der TrkB-Rezeptoren gehemmt, und gleichzeitig wird ihre Menge in den Membranen der synaptischen Zellen erh\u00f6ht. Infolgedessen werden die Wirkungen von BDNF verst\u00e4rkt. Mit anderen Worten: Antidepressiva aktivieren TrkB eigentlich nicht direkt<\/strong>. Was sie tats\u00e4chlich tun, ist, den Rezeptor f\u00fcr die Wirkung von BDNF zu sensibilisieren.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”46px|40px|41px|40px||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ link_text_color=”#000000″ header_2_font=”|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”40px” header_2_line_height=”1.2em” z_index=”2″ background_layout=”dark” max_width=”70%” max_width_tablet=”90%” max_width_phone=”100%” max_width_last_edited=”on|tablet” module_alignment=”center” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n All das ist wichtig, denn es gibt Hinweise darauf, dass Menschen, die selbstmordgef\u00e4hrdet sind oder Selbstmord begangen haben, einen niedrigen Cholesterinspiegel haben<\/strong>. Das Problem dabei ist, dass es kompliziert ist, einen direkten Bezug dazu herzustellen. Vor allem, weil das Gehirn haupts\u00e4chlich das selbst produzierte Cholesterin verwendet.<\/p>\n Zus\u00e4tzlich k\u00f6nnte es einen Konflikt mit Statinen geben, die Medikamente sind, die von Millionen von Menschen auf der ganzen Welt konsumiert werden. Diese Medikamente werden zur Kontrolle des Cholesterinspiegels im Blut eingesetzt. In der Tat fragten sich die Forscher, ob die Statine die antidepressive Wirkung blockieren w\u00fcrden<\/strong>.<\/p>\n Die Forschung diente auch dazu, zu zeigen, dass Antidepressiva die Neuroplastizit\u00e4t nicht mehr erh\u00f6hten, wenn sie mit einer hohen Dosis von Statinen injiziert wurden, mit dem Ziel, den Cholesterinspiegel im Gehirn zu senken. Sp\u00e4ter analysierten die Forscher Humanstudien, in denen dies nicht geschieht, weil die Statine das Gehirn nicht erreichen.<\/p>\n Das hei\u00dft, mit den beim Menschen \u00fcblichen Dosen von Statinen verursachen diese Medikamente keine Probleme. Was den Cholesterinspiegel im Blut angeht, sind sich die Wissenschaftler einig, dass mehr Forschung n\u00f6tig ist, um einen Zusammenhang zu finden.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.16″ background_color=”#f3f3f1″ custom_padding=”36px|0px|0px|0px||” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/cbd-antidepresivo.jpg” alt=”cbd Antidepressivum” title_text=”cbd Antidepressivum” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ animation_style=”slide” animation_direction=”right” animation_intensity_slide=”5%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”||||||||” text_font_size=”16px” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Da die Forscher nun wissen, dass die Plastizit\u00e4t des Gehirns f\u00fcr die Wirkung von Antidepressiva von grundlegender Bedeutung ist, stellt sich die Frage: Warum wirken manche Antidepressiva schneller als andere? Wissenschaftler wissen, dass viele herk\u00f6mmliche Antidepressiva<\/strong> wie Escitalopram oder Fluoxetin erst nach Wochen beginnen, auf einer psychologisch sichtbaren Ebene zu wirken.<\/p>\n Im Gegensatz dazu gibt es andere Antidepressiva, die viel schneller wirken, wie z.B. das bereits erw\u00e4hnte Ketamin. Das Problem scheint mit der Zeit<\/strong> zusammenzuh\u00e4ngen, die diese Medikamente ben\u00f6tigen, um die erforderlichen Konzentrationen im Gehirn zu erreichen<\/strong>. Das w\u00e4re der Grund, warum es mehrere Tage dauert, und auch, warum man nicht aufh\u00f6ren kann, sie zu konsumieren.<\/p>\n Bei schnell wirkenden Medikamenten kann es sein, dass sie die Blut-Hirn-Schranke leichter durchdringen k\u00f6nnen, bis sie schlie\u00dflich die f\u00fcr die Aktivierung des TrkB-Rezeptors erforderliche Konzentration erreichen.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/investigacion-antidepresivos.jpg” alt=”Antidepressiva-Forschung” title_text=”Antidepressiva-Forschung” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ animation_style=”slide” animation_direction=”right” animation_intensity_slide=”5%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”||||||||” text_font_size=”16px” header_2_font=”|800|||||||” header_2_font_size=”40px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.16″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ custom_margin=”|auto|-2px|auto||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/antidepresivos-cbd-corto-plazo.jpg” alt=”Kurzfristige cbd Antidepressiva” title_text=”Kurzfristige cbd Antidepressiva” align=”center” _builder_version=”4.16″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n Die Ergebnisse zeigten, dass Cannabidiol CBD bei M\u00e4usen eine dosisabh\u00e4ngige antidepressive Wirkung induzierte. Derselbe Test wurde auch an Ratten durchgef\u00fchrt, und die erhaltenen Ergebnisse waren \u00e4hnlich wie die der M\u00e4use. Die Forscher fanden<\/strong> auch heraus, dass alle diese akuten antidepressiven Wirkungen<\/strong>, die nach dem Schwimmtest 30 Minuten nach der Behandlung bewertet wurden, mit der F\u00e4higkeit von Cannabidiol zusammenhingen, den BDNF-Spiegel zu erh\u00f6hen<\/strong>.<\/p>\n Diese erh\u00f6hten BDNF-Spiegel waren sowohl im Hippocampus als auch im pr\u00e4frontalen Kortex der Nager vorhanden. Dies ist wichtig, weil der Brain-Derived Neurotrophic Factor (BDNF) ein entscheidender Faktor f\u00fcr das Wachstum von Neuronen ist. Und nicht nur das: Die Forscher entdeckten auch, dass Marker der synaptischen Plastizit\u00e4t<\/strong>, die f\u00fcr den Umbau des Gehirns unerl\u00e4sslich sind, im pr\u00e4frontalen Kortex des Gehirns ebenfalls einen Anstieg erfuhren.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature” _builder_version=”4.16″ background_color=”#f3f3f1″ background_enable_image=”off” custom_padding=”21px||18px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ custom_margin=”|auto|-2px|auto||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/cbd-antidepresivos-largo-plazo.jpg” alt=”cbd antidepressiva langfristig” title_text=”cbd antidepressiva langfristig” align=”center” _builder_version=”4.16″ background_enable_image=”off” background_size=”contain” max_width_phone=”300px” max_width_last_edited=”off|tablet” custom_margin=”|||-30%|false|false” custom_margin_tablet=”|||-15%|false|false” custom_margin_phone=”|||-10%|false|false” custom_margin_last_edited=”on|phone” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding_tablet=”|20%|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_2_font=”|800|||||||” header_2_text_color=”#000000″ header_2_font_size=”40px” header_2_line_height=”1.2em” custom_margin=”||||false|false” custom_margin_tablet=”|||0%|false|false” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”35px” header_2_font_size_phone=”25px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font_size_tablet=”14px” text_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n Was die antidepressiven Wirkungen von Cannabidiol CBD auf lange Sicht betrifft, fanden die Wissenschaftler heraus, dass sie mit einer Verbesserung der synaptischen Funktion im pr\u00e4frontalen Kortex verbunden waren<\/strong>. Dies war der Schwimmtest bei M\u00e4usen, der 7 Tage nach Verabreichung der CBD-Dosis ausgewertet wurde.<\/p>\n Die Ergebnisse unterst\u00fctzen die Theorie, dass das aus Cannabis extrahierte Cannabidiol CBD tats\u00e4chlich ein schnell wirkendes Antidepressivum ist. Nicht nur das, aber seine antidepressive Wirkung ist nachhaltig. Mit anderen Worten: CBD-Konsum in angemessenen Dosen k\u00f6nnte zu einer l\u00e4ngerfristigen antidepressiven Wirkung f\u00fchren.<\/p>\n Obwohl offensichtlich noch mehr Forschung zu diesem Thema erforderlich ist, deuten die Ergebnisse dieser Studien darauf hin, dass CBD eine vielversprechende therapeutische Behandlung f\u00fcr Stimmungsst\u00f6rungen und insbesondere Depressionen sein k\u00f6nnte.<\/p>\n Wir sollten nicht vergessen, dass CBD bereits f\u00fcr seine gesundheitlichen Vorteile bei anderen Erkrankungen wie Alzheimer, chronischen Schmerzen oder neurologischen Funktionsst\u00f6rungen bekannt ist. Daher w\u00e4re es nicht verwunderlich, wenn es auch einen positiven Effekt bei der Behandlung von Depressionen h\u00e4tte.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Features” _builder_version=”4.16″ background_color=”#f3f3f1″ custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” admin_label=”CTA Row” module_class=” et_pb_row_fullwidth” _builder_version=”4.16″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_enable_image=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/cbd-depresion.jpg” alt=”cbd-Depresion” title_text=”cbd-Depresion” force_fullwidth=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_color=”#00a88d” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_cta title=”Die Rolle von CBD bei Depressionen” button_url=”#top” _builder_version=”4.16″ header_font=”|800|||||||” header_text_color=”#ffffff” body_font=”Montserrat|500|||||||” body_text_color=”#ffffff” body_link_text_color=”#000000″ use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#2f3854″ button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”60px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” button_alignment=”left” text_orientation=”left” max_width=”580px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”left” custom_margin=”|||” custom_padding=”40px|60px|2px|60px||” button_text_color_hover=”#2f3854″ button_border_radius_hover=”66px” button_letter_spacing_hover=”1px” button_bg_color_hover=”#ffffff” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#2f3854″ button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”66px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”1px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#ffffff” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]Wie bereits erw\u00e4hnt, k\u00f6nnen die derzeitigen Behandlungsm\u00f6glichkeiten f\u00fcr Depressionen, zu denen auch der Einsatz von Antidepressiva geh\u00f6rt, problematisch sein. Das liegt vor allem daran, dass die Patienten oft mit einer Verz\u00f6gerung der Wirkung zu k\u00e4mpfen haben. In diesem Sinne k\u00f6nnte CBD das Potenzial haben, eine effiziente Alternative im Kampf gegen Depressionen zu sein<\/strong>.<\/p>\n Eine Untersuchung aus dem Jahr 2019 ergab, dass Cannabidiol (CBD) \u00e4hnliche Wirkungen wie schnell wirkende und anhaltende Antidepressiva hervorruft<\/a>. All dies durch erh\u00f6hte BDNF-Signalisierung und Synaptogenese im pr\u00e4frontalen Kortex des Gehirns. Forscher an der Universit\u00e4t von Sao Paulo in Brasilien testeten die antidepressive Wirkung von CBD<\/strong> an Ratten und M\u00e4usen, um festzustellen, ob dieses Cannabidiol einen schnellen Wirkungseintritt hat.<\/p>\n W\u00e4hrend der Forschung wurde CBD als Einzeldosis in einer Menge verabreicht, die 7, 10 oder 30 mg pro Kilogramm K\u00f6rpergewicht betragen konnte. Die Wissenschaftler unterzogen die Nager dann einem erzwungenen Schwimmtest nach 30 Minuten oder bis zu 7 Tage nach Beginn der Behandlung.[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Subscribe” _builder_version=”4.16″ use_background_color_gradient=”on” background_color_gradient_stops=”#f3f3f1 0%|rgba(255,255,255,0) 30%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#f3f3f1″ background_color_gradient_end=”rgba(255,255,255,0)” background_color_gradient_end_position=”30%” background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/aceite-de-cannabis-cbd.jpg” custom_padding=”100px|0px|30vw|0px” animation_direction=”bottom” saved_tabs=”all” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”|500|||||||” text_text_color=”rgba(47,56,84,0.5)” text_font_size=”16px” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”|700|||||||” header_2_font_size=”50px” header_2_line_height=”1.3em” text_orientation=”center” max_width=”700px” module_alignment=”center” global_colors_info=”{}”]<\/p>\n Abonnieren Sie und erhalten Sie 10% Rabatt auf Ihren Kauf. <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_2,1_4″ _builder_version=”4.16″ custom_padding=”19px|||||” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_signup mailchimp_list=”higeacbd|5b4d14cf0e” first_name_field=”off” last_name_field=”off” _builder_version=”4.16″ header_font=”||||||||” use_background_color=”off” custom_button=”on” button_text_size=”16px” button_text_color=”#ffffff” button_bg_color=”#00a88d” button_border_width=”10px” button_border_color=”rgba(47,56,84,0)” button_border_radius=”89px” button_letter_spacing=”1px” button_font=”Montserrat|700||on|||||” button_use_icon=”off” border_radii_fields=”on|30px|30px|30px|30px” border_width_all_fields=”1px” border_color_all_fields=”rgba(47,56,84,0.2)” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_signup][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer” _builder_version=”4.5.1″ background_color=”#f3f3f1″ background_image=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/cannabis-medicinal.jpg” background_size=”contain” background_position=”bottom_center” global_module=”452″ saved_tabs=”all” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ make_equal=”on” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”#000000″ custom_padding=”4%|5%|4%|4%|true|false” custom_padding_tablet=”50px|30px|50px|30px|true|true” custom_padding_phone=”30px|20px|30px|20px|true|true” custom_padding_last_edited=”off|desktop” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|800|||||||” text_font_size=”30px” text_line_height=”1.2em” link_text_color=”#000000″ header_3_font=”|700||on|||||” header_3_text_color=”#96bf00″ header_3_font_size=”16px” header_3_letter_spacing=”2px” header_3_line_height=”1.8em” header_4_font=”|700||on|||||” header_4_text_color=”#00a88d” header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”1.8em” custom_margin=”||0px||false|false” custom_padding=”10px||10px||true|false” text_font_size_tablet=”22px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”14px” header_3_font_size_phone=”12px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png” alt=”simbolo higea” title_text=”simbolo higea” _builder_version=”4.16″ custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n CBD bei 5%<\/a><\/p>\n [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]CBD bei 10%<\/a>[\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n CBD bei 20%<\/a><\/p>\n [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”V||divi||400″ icon_placement=”left” _builder_version=”4.16″ header_font=”|700||on|||||” header_text_color=”#ffffff” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.8em” body_font=”|700||on|||||” body_text_color=”#FFFFFF” body_font_size=”16px” body_letter_spacing=”2px” body_line_height=”1.8em” custom_margin=”||0px||false|false” animation=”off” header_font_size_tablet=”14px” header_font_size_phone=”12px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”14px” body_font_size_phone=”12px” body_font_size_last_edited=”on|desktop” 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global_colors_info=”{}”] Wie wirken Antidepressiva? Neue Studie enth\u00fcllt die Wahrheit<\/h2>\n
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BDNF und seine Beziehung zur neuronalen Plastizit\u00e4t<\/h2>\n
Ketamin hat eine schnellere antidepressive Wirkung<\/h2>\n
Cholesterin kann eine Schl\u00fcsselrolle bei der Wirkung von Antidepressiva spielen<\/h2>\n
Mehr Forschung zu Cholesterin und Antidepressiva erforderlich<\/h2>\n
Warum wirken manche Antidepressiva schneller als andere?<\/h2>\n
Kernpunkte der Untersuchung<\/h2>\n
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Kurzfristige antidepressive Wirkung von CBD<\/h2>\n
Langfristige antidepressive Wirkung von CBD<\/h2>\n
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