{"id":8417,"date":"2020-09-01T09:49:20","date_gmt":"2020-09-01T09:49:20","guid":{"rendered":"https:\/\/higeacbd.com\/sense-categoria\/biodisponibilitat-i-cbd\/"},"modified":"2021-11-12T11:01:48","modified_gmt":"2021-11-12T11:01:48","slug":"biodisponibilitat-i-cbd","status":"publish","type":"post","link":"https:\/\/higeacbd.com\/ca\/datos\/biodisponibilitat-i-cbd","title":{"rendered":"Biodisponibilitat i CBD"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Hero&#8221; _builder_version=&#8221;4.5.8&#8243; background_color=&#8221;rgba(255,255,255,0.65)&#8221; background_image=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/aceite-cbd-biodisponibilidad.jpg&#8221; background_blend=&#8221;soft-light&#8221; custom_padding=&#8221;3vw||1vw|||&#8221;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_cta title=&#8221;Biodisponibilitat i CBD&#8221; _builder_version=&#8221;4.5.8&#8243; header_level=&#8221;h1&#8243; header_font=&#8221;|800|||||||&#8221; header_font_size=&#8221;45px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;|800|||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;20px&#8221; body_line_height=&#8221;1.6em&#8221; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#00a88d&#8221; button_border_width=&#8221;8px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;60px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;light&#8221; animation_direction=&#8221;bottom&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;50px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; button_text_color_hover=&#8221;#ffffff&#8221; button_border_radius_hover=&#8221;66px&#8221; button_letter_spacing_hover=&#8221;1px&#8221; button_bg_color_hover=&#8221;rgba(47,56,84,0.9)&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;on&#8221; button_text_color__hover=&#8221;#ffffff&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;on&#8221; button_border_radius__hover=&#8221;66px&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;on&#8221; button_letter_spacing__hover=&#8221;1px&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;on&#8221; button_bg_color__hover=&#8221;rgba(47,56,84,0.9)&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;]<\/p>\n<p>Aix\u00f2 \u00e9s el que la biodisponibilitat \u00e9s i quins valors d&#8217;oli de CBD s\u00f3n<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Products&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;20px||11px||false|false&#8221;][et_pb_row _builder_version=&#8221;4.5.1&#8243; custom_padding=&#8221;8px||17px|||&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.5.8&#8243; text_font=&#8221;|500|||||||&#8221; text_text_color=&#8221;#000000&#8243; quote_font=&#8221;||||||||&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.4em&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||12px|||&#8221;]<\/p>\n<p>Abans <a href=\"https:\/\/higeacbd.com\/ca\/beneficis-del-cbd\" title=\"Beneficios del CBD\">d&#8217;iniciar qualsevol tractament ja sigui basat en CDB<\/a> o un altre compost hem d&#8217;entendre com reaccionar\u00e0 el nostre cos a la dosi que consumim. Un estudi exhaustiu de la quantitat que el nostre cos assimilar\u00e0 \u00e9s essencial per obtenir els resultats que volem. Hi ha diversos factors que fan que cada persona necessiti una quantitat diferent de la mateixa subst\u00e0ncia <strong>i la biodisponibilitat d&#8217;un<\/strong> f\u00e0rmac juga un paper molt important.<\/p>\n<p>En el primer moment definirem uns termes farmacol\u00f2gics que ens ajudaran al llarg del text a comprendre molt millor els conceptes complexos que ens ajudaran a triar la dosi ideal.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=&#8221;Productes&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_module=&#8221;16824&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221;][et_pb_shop type=&#8221;best_selling&#8221; posts_number=&#8221;8&#8243; show_pagination=&#8221;on&#8221; module_class=&#8221;custom-shop&#8221; _builder_version=&#8221;4.8.1&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|700|||||||&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221;][\/et_pb_shop][et_pb_signup mailchimp_list=&#8221;higeacbd|5b4d14cf0e&#8221; first_name_field=&#8221;off&#8221; last_name_field=&#8221;off&#8221; title=&#8221;Subscriu-te i rep un 10% de descompte&#8221; _builder_version=&#8221;4.8.1&#8243; header_level=&#8221;h4&#8243; header_font=&#8221;|800|||||||&#8221; header_text_align=&#8221;center&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;35px&#8221; header_line_height=&#8221;1.2em&#8221; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#00a88d&#8221; button_bg_color=&#8221;rgba(0,0,0,0)&#8221; button_border_width=&#8221;0px&#8221; button_border_radius=&#8221;0px&#8221; button_letter_spacing=&#8221;2px&#8221; button_font=&#8221;|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; button_custom_padding=&#8221;18px|0px|18px|0px|true|true&#8221; button_custom_padding_tablet=&#8221;14px||14px||true|true&#8221; button_custom_padding_phone=&#8221;12px||12px||true|true&#8221; button_custom_padding_last_edited=&#8221;on|phone&#8221; background_layout=&#8221;light&#8221; header_font_size_tablet=&#8221;25px&#8221; header_font_size_phone=&#8221;20px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; button_text_size_tablet=&#8221;14px&#8221; button_text_size_phone=&#8221;12px&#8221; button_text_size_last_edited=&#8221;on|phone&#8221; box_shadow_style_button=&#8221;preset4&#8243; box_shadow_horizontal_button=&#8221;0px&#8221; box_shadow_vertical_button=&#8221;2px&#8221; box_shadow_color_button=&#8221;#00a88d&#8221; button_text_color__hover=&#8221;#28221d&#8221; button_text_color__hover_enabled=&#8221;on|hover&#8221; box_shadow_color_button__hover=&#8221;#000000&#8243; box_shadow_color_button__hover_enabled=&#8221;on|desktop&#8221;][\/et_pb_signup][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;14px||27px|||&#8221;][et_pb_row _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;12px||13px|||&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.6.6&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;35px&#8221; header_2_line_height=&#8221;1.2em&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||-5px|||&#8221; custom_padding=&#8221;||0px|||&#8221;]<\/p>\n<h2>Farmacocin\u00e8tica<\/h2>\n<p>La seva etimologia ja ens d\u00f3na una pista sobre el que aquesta branca de la ci\u00e8ncia pot tractar. D&#8217;una banda &#8220;Farmacol\u00f2gic&#8221; ens diu que est\u00e0 <a href=\"https:\/\/higeacbd.com\/ca\/datos\/farmacodinamica-i-farmacocinetica\" title=\"Farmacodinamia\">relacionat amb la farmacologia<\/a> i &#8220;cin\u00e8tica&#8221; podem inferir que t\u00e9 a veure amb alguna cosa que est\u00e0 en moviment. De fet, la farmacocin\u00e8tica estudia com els f\u00e0rmacs es mouen a trav\u00e9s del nostre cos, d&#8217;entrar a sortir del nostre cos.<\/p>\n<h2>Ruta de l&#8217;Administraci\u00f3<\/h2>\n<p>Es refereix a on una subst\u00e0ncia entra en el nostre organisme. Pot ser intravenosa, oral, t\u00f2pica, rectal, etc&#8230;<\/p>\n<h2>Diana Terap\u00e8utica<\/h2>\n<p>\u00c9s l&#8217;organisme objectiu sobre el qual funcionen els f\u00e0rmacs. Solen ser prote\u00efnes, l\u00edpids i \u00e0cids nucleics.<\/p>\n<h2>Absorci\u00f3<\/h2>\n<p>En farmacocin\u00e8tica, l&#8217;absorci\u00f3 del proc\u00e9s de penetraci\u00f3 de f\u00e0rmacs per les membranes cel\u00b7lulars per arribar a la sang es diu absorci\u00f3. L&#8217;administraci\u00f3 intravenosa omet directament el proc\u00e9s d&#8217;absorci\u00f3.<\/p>\n<h2>Distribuci\u00f3<\/h2>\n<p>Es refereix a com el f\u00e0rmac viatja a trav\u00e9s de la sang als diferents teixits del cos.<\/p>\n<h2>Metabolisme<\/h2>\n<p>El nostre cos transforma les drogues en by-products per facilitar la seva eliminaci\u00f3. Un f\u00e0rmac que es subministra per via oral sempre passar\u00e0 pel filtre metab\u00f2lic que el trencar\u00e0 en els productes i no passar\u00e0 al torrent sanguini al 100%<\/p>\n<h2>Excreci\u00f3<\/h2>\n<p>\u00c9s el proc\u00e9s pel qual el nostre cos acaba traient les drogues<\/p>\n<h2>Concentraci\u00f3 plasm\u00e0tica<\/h2>\n<p>\u00c9s la quantitat de f\u00e0rmac que passa al torrent sanguini i est\u00e0 disponible per al nostre cos.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;0px|0px|0px|0px&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; make_equal=&#8221;on&#8221; admin_label=&#8221;Cta Fila&#8221; module_class=&#8221; et_pb_row_fullwidth&#8221; _builder_version=&#8221;4.5.1&#8243; width=&#8221;100%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;&#8221; width_last_edited=&#8221;on|desktop&#8221; max_width=&#8221;100%&#8221; max_width_tablet=&#8221;100%&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px|0px|0px|0px&#8221; make_fullwidth=&#8221;on&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-cbd.jpg&#8221; alt=&#8221;cbd biodisponibilitat&#8221; title_text=&#8221;cbd biodisponibilitat&#8221; force_fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.5.8&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_cta title=&#8221;Llavors, qu\u00e8 \u00e9s la biodisponibilitat?&#8221; button_url=&#8221;#top&#8221; _builder_version=&#8221;4.5.8&#8243; header_font=&#8221;|800|||||||&#8221; header_text_color=&#8221;#ffffff&#8221; body_font=&#8221;Montserrat|500|||||||&#8221; body_text_color=&#8221;#ffffff&#8221; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#2f3854&#8243; button_border_width=&#8221;10px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;60px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; button_alignment=&#8221;left&#8221; text_orientation=&#8221;left&#8221; max_width=&#8221;580px&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; module_alignment=&#8221;left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;40px|60px|2px|60px||&#8221; button_text_color_hover=&#8221;#2f3854&#8243; button_border_radius_hover=&#8221;66px&#8221; button_letter_spacing_hover=&#8221;1px&#8221; button_bg_color_hover=&#8221;#ffffff&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;on&#8221; button_text_color__hover=&#8221;#2f3854&#8243; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;on&#8221; button_border_radius__hover=&#8221;66px&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;on&#8221; button_letter_spacing__hover=&#8221;1px&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;on&#8221; button_bg_color__hover=&#8221;#ffffff&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;]<\/p>\n<p>En Farmacocin\u00e8tica la <strong>Biodisponibilitat d&#8217;un f\u00e0rmac<\/strong> forma part de l&#8217;estudi de l&#8217;absorci\u00f3 i \u00e9s el percentatge i taxa a la qual el compost arriba al plasma en la nostra circulaci\u00f3 sist\u00e8mica. Per tant, si un producte medicinal es <strong>lliura per via intravenosa (IV), per definici\u00f3, la seva Biodisponibilitat \u00e9s 100%.<\/strong> El nostre cos tindria llavors el 100% del compost disponible en el sistema circulatori per aconseguir la diana terap\u00e8utica.<\/p>\n<p>Per tant, podem inferir que per <strong>calcular la biodisponibilitat d&#8217;un f\u00e0rmac<\/strong> \u00e9s essencial diferenciar les rutes d&#8217;administraci\u00f3. A la taula seg\u00fcent es detalla la biodisponibilitat per a cada via:<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad.jpg\" width=\"800\" height=\"458\" alt=\"Biodisponibilitat\" class=\"wp-image-5773 alignnone size-full\" srcset=\"https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad.jpg 800w, https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-480x275.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 800px, 100vw\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/curva-de-concentracion-plasmatica.jpg\" width=\"800\" height=\"805\" alt=\"corba de concentraci\u00f3 plasm\u00e0tica\" class=\"wp-image-5766 alignnone size-full\" srcset=\"https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/curva-de-concentracion-plasmatica.jpg 800w, https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/curva-de-concentracion-plasmatica-480x483.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 800px, 100vw\" \/><\/p>\n<p>[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;14px||27px|||&#8221;][et_pb_row _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;12px||13px|||&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.5.8&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;35px&#8221; header_2_line_height=&#8221;1.2em&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||-5px|||&#8221; custom_padding=&#8221;||0px|||&#8221;]<\/p>\n<p>La manera m\u00e9s comuna i segura de prendre qualsevol droga a casa \u00e9s oral. Quan ingerim un medicament \u00e9s absorbit pel fetge que s&#8217;encarrega de passar-lo al torrent sanguini. No obstant aix\u00f2, no tot el f\u00e0rmac arriba a la nostra circulaci\u00f3 sist\u00e8mica, ja que el metabolisme del primer pas del fetge descompensa algunes de les subst\u00e0ncies actives que mai circularan a trav\u00e9s del nostre cos. Per tant, quan volem calcular la biodisponibilitat d&#8217;un f\u00e0rmac administrat per via oral tamb\u00e9 hem de tenir en compte aquest efecte del metabolisme del primer pas hep\u00e0tic.<\/p>\n<p>Alguns compostos (com el CBD que anem a discutir m\u00e9s tard) tenen un gran efecte en el primer pas pel que s&#8217;administra per via oral no aconsegueixen prou concentraci\u00f3 plasm\u00e0tica per aconseguir l&#8217;objectiu terap\u00e8utic. En aquests casos s&#8217;indica la recerca d&#8217;una ruta alternativa d&#8217;administraci\u00f3. La manera m\u00e9s comuna i segura de prendre qualsevol droga a casa \u00e9s oral. Quan ingerim un medicament \u00e9s absorbit pel fetge que s&#8217;encarrega de passar-lo al torrent sanguini. No obstant aix\u00f2, no tot el f\u00e0rmac arriba a la nostra circulaci\u00f3 sist\u00e8mica, ja que el metabolisme del primer pas del fetge descompensa algunes de les subst\u00e0ncies actives que mai circularan a trav\u00e9s del nostre cos.<\/p>\n<p>Per tant, quan volem calcular la biodisponibilitat d&#8217;un f\u00e0rmac administrat per via oral tamb\u00e9 hem de tenir en compte aquest efecte del metabolisme del primer pas hep\u00e0tic. Alguns compostos (com el CBD que anem a discutir m\u00e9s tard) tenen un gran efecte en el primer pas pel que s&#8217;administra per via oral no aconsegueixen prou concentraci\u00f3 plasm\u00e0tica per aconseguir l&#8217;objectiu terap\u00e8utic. En aquests casos s&#8217;indica la recerca d&#8217;una ruta alternativa d&#8217;administraci\u00f3.<\/p>\n<p><a href=\"https:\/\/higeacbd.com\/ca\/com-prendre-oli-de-cbd-guia-per-comencar\" title=\"Com prendre oli de CBD\">L&#8217;administraci\u00f3 subling\u00fce,<\/a>per exemple, augmenta la biodisponibilitat de la droga ja que sota la llengua tenim innombrables capil\u00b7lars i el teixit \u00e9s prou permeable perqu\u00e8 la subst\u00e0ncia passi directament al torrent sanguini. Un parell d&#8217;exemples de biodisponibilitat d&#8217;alguns f\u00e0rmacs que estem m\u00e9s familiaritzats amb:<\/p>\n<ul>\n<li>Ibuprof\u00e8n per via oral: 49-73%<\/li>\n<li>Paracetamol per via oral: 63-89%<\/li>\n<li>Aspirina oral: 80-100%<\/li>\n<li>Amoxicil\u00b7lina per via oral: 95%<\/li>\n<\/ul>\n<h3>Altres factors que influeixen en la biodisponibilitat d&#8217;un f\u00e0rmac inclouen:<\/h3>\n<ul>\n<li>Edat del pacient<\/li>\n<li>Pes del pacient<\/li>\n<li>Altres subst\u00e0ncies consumides pel pacient simult\u00e0niament<\/li>\n<li>Malalties o disfuncions del pacient<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;40px||40px|||&#8221; locked=&#8221;off&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.4.4&#8243; locked=&#8221;off&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.4.4&#8243;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-en-alimentos.jpg&#8221; alt=&#8221;biodisponibilitat en els aliments&#8221; title_text=&#8221;biodisponibilitat en els aliments&#8221; _builder_version=&#8221;4.5.8&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.4.4&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221;][et_pb_text _builder_version=&#8221;4.5.8&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221;]<\/p>\n<h2>La biodisponibilitat dels nutrients en els aliments<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.2&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221;]<\/p>\n<p>Estudiar la <strong>biodisponibilitat dels nutrients <a href=\"https:\/\/higeacbd.com\/ca\/planta\/lecitina-en-aliments-de-cannabis\" title=\"Lecitina alimento con cannabis\">en els aliments \u00e9s fonamental<\/a> <\/strong> per entendre com alimentar tota la poblaci\u00f3 amb els recursos disponibles. \u00c9s per aix\u00f2 que s&#8217;estan fent enormes esfor\u00e7os per entendre la biodisponibilitat dels nutrients en cada aliment i quins factors de l&#8217;individu poden influir en ell.<\/p>\n<p>Els macronutrients (prote\u00efnes, hidrats de carboni i greixos) aconsegueixen una biodisponibilitat de fins al 90%. At\u00e8s que els macronutrients gaudeixen d&#8217;una biodisponibilitat tan elevada, el valor biol\u00f2gic t\u00e9 una gran import\u00e0ncia, per exemple, preferim greixos insaturats rics en \u00e0cids omega 3, 6 i 9 i prote\u00efnes que contenen la major quantitat d&#8217;amino\u00e0cids essencials que el nostre cos no \u00e9s capa\u00e7 de sintetitzar.<\/p>\n<p>No obstant aix\u00f2, l&#8217;estudi de la biodisponibilitat de micronutrients com vitamines i minerals \u00e9s molt m\u00e9s complicat ja que el seu proc\u00e9s digestiu \u00e9s m\u00e9s complex i implica molts m\u00e9s factors que alteren la biodisponibilitat d&#8217;aquests en cada individu.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;0px|0px|0px|0px&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; make_equal=&#8221;on&#8221; admin_label=&#8221;Cta Fila&#8221; module_class=&#8221; et_pb_row_fullwidth&#8221; _builder_version=&#8221;4.5.1&#8243; width=&#8221;100%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;&#8221; width_last_edited=&#8221;on|desktop&#8221; max_width=&#8221;100%&#8221; max_width_tablet=&#8221;100%&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px|0px|0px|0px&#8221; make_fullwidth=&#8221;on&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/biodisponibilidad-en-el-cbd.jpg&#8221; alt=&#8221;biodisponibilitat en cbd&#8221; title_text=&#8221;biodisponibilitat en cbd&#8221; force_fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.5.8&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_cta title=&#8221;Quina \u00e9s la biodisponibilitat de l&#8217;oli de CBD? Quina \u00e9s la ruta \u00f2ptima d&#8217;administraci\u00f3?&#8221; button_url=&#8221;#top&#8221; _builder_version=&#8221;4.5.8&#8243; header_font=&#8221;|800|||||||&#8221; header_text_color=&#8221;#ffffff&#8221; body_font=&#8221;Montserrat|500|||||||&#8221; body_text_color=&#8221;#ffffff&#8221; body_link_text_color=&#8221;#000000&#8243; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#2f3854&#8243; button_border_width=&#8221;10px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;60px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; button_alignment=&#8221;left&#8221; text_orientation=&#8221;left&#8221; max_width=&#8221;580px&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; module_alignment=&#8221;left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;40px|60px|2px|60px||&#8221; button_text_color_hover=&#8221;#2f3854&#8243; button_border_radius_hover=&#8221;66px&#8221; button_letter_spacing_hover=&#8221;1px&#8221; button_bg_color_hover=&#8221;#ffffff&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;on&#8221; button_text_color__hover=&#8221;#2f3854&#8243; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;on&#8221; button_border_radius__hover=&#8221;66px&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;on&#8221; button_letter_spacing__hover=&#8221;1px&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;on&#8221; button_bg_color__hover=&#8221;#ffffff&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;]<\/p>\n<p>Moltes vegades ens fixem <a href=\"https:\/\/higeacbd.com\/ca\/olis-portadors\" title=\"Olis portadors\">en la concentraci\u00f3 d&#8217;olis<\/a> abans de deixar de pensar exactament quant hem de tractar el nostre problema. \u00c9s per aix\u00f2 que, a continuaci\u00f3, intentarem entendre com el nostre cos absorbeix el CBD. Recorda que la ruta per la qual l&#8217;administrem determinar\u00e0 la seva absorci\u00f3 i biodisponibilitat.<\/p>\n<h3>C\u00e0psules orals<\/h3>\n<p>Una de les rutes d&#8217;administraci\u00f3 m\u00e9s comunes \u00e9s en c\u00e0psules comestibles que passaran pel nostre sistema digestiu i el CBD ser\u00e0 absorbit pel fetge. CDB t\u00e9 un efecte metabolisme de primer pas hep\u00e0tic bastant alt, de manera que el nostre fetge es descompondr\u00e0 deixant una biodisponibilitat de tan baix com 4% &#8211; 20% (segons estudis recents). Per descomptat, la ind\u00fastria est\u00e0 tractant de respondre a aquest problema de biodisponibilitat de CBD per via oral i mitjan\u00e7ant la investigaci\u00f3 d&#8217;emulsions solubles en aigua que augmenten l&#8217;absorci\u00f3 i la biodisponibilitat fins a gaireb\u00e9 50%. Si optem per aquesta ruta d&#8217;administraci\u00f3 tamb\u00e9 hem de tenir en compte si el nostre est\u00f3mac est\u00e0 buit o ple abans de consumir les c\u00e0psules. El CBD \u00e9s soluble en greixos que si l&#8217;acompanyem amb \u00e0pats d&#8217;alta greix podem augmentar la seva biodisponibilitat per via oral.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.5.1&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;21px||18px|||&#8221; locked=&#8221;off&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.5.1&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.5.1&#8243;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/farmacodinamia-cannabinoides.jpg&#8221; alt=&#8221;cannabinoides farmacodin\u00e0mics&#8221; title_text=&#8221;cannabinoides farmacodin\u00e0mics&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.5.8&#8243; background_enable_image=&#8221;off&#8221; background_size=&#8221;contain&#8221; max_width_phone=&#8221;300px&#8221; max_width_last_edited=&#8221;off|tablet&#8221; custom_margin=&#8221;|||-30%|false|false&#8221; custom_margin_tablet=&#8221;|||-15%|false|false&#8221; custom_margin_phone=&#8221;|||-10%|false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.4.4&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221;]<\/p>\n<h3>El CBD concentra subling\u00fcament<\/h3>\n<p>L&#8217;administraci\u00f3 subling\u00fce de qualsevol f\u00e0rmac augmentar\u00e0 autom\u00e0ticament la biodisponibilitat de la droga, ja que les membranes mucoses absorbiran part de la subst\u00e0ncia activa directament al torrent sanguini. Per a aix\u00f2, haur\u00e0 de mantenir les gotetes d&#8217;oli durant 90 segons sota la llengua abans d&#8217;empassar-los. Amb l&#8217;administraci\u00f3 subling\u00fce es pot aconseguir 12% a 35% biodisponibilitat de CBD.<\/p>\n<h3>Vapeig e-l\u00edquid (inhalaci\u00f3)<\/h3>\n<p>En vapeig olis de CBD inhalem el compost que arriba al nostre pulm\u00f3. Els alv\u00e8ols pulmonars seran els encarregats de transportar la subst\u00e0ncia activa molt r\u00e0pidament al torrent sanguini perqu\u00e8 l&#8217;absorci\u00f3 sigui gaireb\u00e9 instant\u00e0nia i es pugui aconseguir una biodisponibilitat superior al 50%.<\/p>\n<h3>\u00das t\u00f2pic<\/h3>\n<p>Hi ha innombrables cremes i b\u00e0lsams amb CBD com a subst\u00e0ncia activa. La pell \u00e9s una membrana molt densa i baixa permeabilitat que afecta directament l&#8217;absorci\u00f3. \u00c9s per aquest motiu que si triem la ruta t\u00f2pica per gaudir dels beneficis del CBD hauran de mirar molt a la concentraci\u00f3 de Cannabidiol d&#8217;aquests productes. Aquesta \u00e9s la millor manera de calmar els dolors localitzats, s&#8217;han d&#8217;aplicar capes denses de producte a la pell i deixar que funcioni fins que la pell acabi absorbint. En qualsevol cas, l&#8217;aplicaci\u00f3 de <a href=\"https:\/\/higeacbd.com\/ca\/dades\/els-cannabinoides-sabsorbeixen-a-traves-de-la-pell\" title=\"CBD a trav\u00e9s de la piel\">qualsevol concentraci\u00f3 de CBD a la pell<\/a> no far\u00e0 que arribi al torrent sanguini pel que la seva biodisponibilitat \u00e9s zero. Hi ha pegats transd\u00e8rmics de CBD que s&#8217;absorbeixen en el torrent sanguini, per\u00f2 la seva biodisponibilitat exacta encara no es coneix.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.5.1&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.5.1&#8243;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/08\/porque-tenemos-receptores-cannabinoides.jpg&#8221; alt=&#8221;perqu\u00e8 tenim receptors de cannabinoides&#8221; title_text=&#8221;perqu\u00e8 tenim receptors de cannabinoides&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.5.8&#8243; background_enable_image=&#8221;off&#8221; background_size=&#8221;contain&#8221; max_width_phone=&#8221;300px&#8221; max_width_last_edited=&#8221;off|tablet&#8221; custom_margin=&#8221;|||-30%|false|false&#8221; custom_margin_tablet=&#8221;|||-15%|false|false&#8221; custom_margin_phone=&#8221;|||-10%|false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.4.4&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221;][et_pb_text _builder_version=&#8221;4.5.8&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;off|desktop&#8221;]<\/p>\n<h2>Sinergies que augmenten la biodisponibilitat: terpens, flavonoides i altres cannabinoides<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.3&#8243; hover_enabled=&#8221;0&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p>Fins ara nom\u00e9s hem parlat de la biodisponibilitat del cannabinoide de CBD a\u00efllat. Alguns estudis demostren que combinar CBD amb altres cannabinoides i terpens presents de forma natural a la planta de c\u00e0nem <a href=\"https:\/\/higeacbd.com\/ca\/dades\/que-es-locimeno-i-el-guaiol-i-les-seves-propietats\" title=\"Ocimeno guaiol\">com el guaiol ocimen o<\/a> <a href=\"https:\/\/higeacbd.com\/ca\/datos\/que-es-humuleno-i-les-seves-propietats\" title=\"Humuleno\">l&#8217;humuleno<\/a> augmenta la biodisponibilitat del compost per qualsevol de les vies d&#8217;administraci\u00f3.<\/p>\n<p>En el mercat podem trobar:<\/p>\n<ul>\n<li><strong>OLI DE CBD Broad Spectrum:<\/strong>Cont\u00e9 CBD amb alguns (no tots) de cannabinoides de c\u00e0nem, terpens <a href=\"https:\/\/higeacbd.com\/ca\/que-son-els-flavonoides\" title=\"Qu\u00e8 s\u00f3n els flavonoides\">i flavonoides.<\/a><\/li>\n<li><strong>OLI CBD Full Spectrum:<\/strong>Cont\u00e9 tots els cannabinoides, terpens i flavonoides de c\u00e0nem. Per a tots els olis de Higea CBD, la concentraci\u00f3 de THC \u00e9s inferior al 0,2% que evita efectes psicoactius.<\/li>\n<\/ul>\n<h2>Quant de temps es triga el nostre cos a eliminar completament el CBD?<\/h2>\n<p>Depenent de la dosi i la ruta d&#8217;administraci\u00f3 del nostre cos prendr\u00e0 m\u00e9s o menys temps per distribuir i <a href=\"https:\/\/higeacbd.com\/ca\/efectes-de-loli-de-cbd\" title=\"Efectos del CBD\">eliminar CDB del nostre sistema.<\/a> Els efectes poden de diverses a 8 hores i la seva eliminaci\u00f3 completa no sol superar una setmana.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Art\u00edculos relacionados blog&#8221; _builder_version=&#8221;4.7.0&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;21px||9px|||&#8221; locked=&#8221;off&#8221;][et_pb_row _builder_version=&#8221;4.5.1&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; 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posts_number=&#8221;6&#8243; include_categories=&#8221;current&#8221; show_more=&#8221;on&#8221; show_author=&#8221;off&#8221; show_date=&#8221;off&#8221; _builder_version=&#8221;4.7.0&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_blog][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Subscribe&#8221; _builder_version=&#8221;4.5.1&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#f3f3f1&#8243; background_color_gradient_end=&#8221;rgba(255,255,255,0)&#8221; background_color_gradient_end_position=&#8221;30%&#8221; background_color_gradient_overlays_image=&#8221;on&#8221; background_image=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/aceite-de-cannabis-cbd.jpg&#8221; custom_padding=&#8221;100px|0px|30vw|0px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_duration=&#8221;1250ms&#8221; animation_intensity_slide=&#8221;1%&#8221; saved_tabs=&#8221;all&#8221;][et_pb_row _builder_version=&#8221;3.25&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.5.1&#8243; text_font=&#8221;|500|||||||&#8221; text_text_color=&#8221;rgba(47,56,84,0.5)&#8221; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;|700|||||||&#8221; header_2_font_size=&#8221;50px&#8221; header_2_line_height=&#8221;1.3em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;700px&#8221; module_alignment=&#8221;center&#8221;]<\/p>\n<h2>Subscriu-te a la nostra newsletter<\/h2>\n<p>Subscriu-te i rep un 10% de descompte en la teva compra.  <\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_2,1_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;19px|||||&#8221;][et_pb_column type=&#8221;1_4&#8243; 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custom_margin=&#8221;||0px||false|false&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221;][\/et_pb_blurb][et_pb_blurb title=&#8221;CDB al 20%&#8221; url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIwOCJ9fQ==@&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;%%53%%&#8221; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.5.1&#8243; _dynamic_attributes=&#8221;url&#8221; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#ffffff&#8221; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221;][\/et_pb_blurb][et_pb_blurb title=&#8221;CDB al 30%&#8221; url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wcm9kdWN0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIxMSJ9fQ==@&#8221; 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