{"id":37261,"date":"2021-03-15T17:28:03","date_gmt":"2021-03-15T17:28:03","guid":{"rendered":"https:\/\/higeacbd.com\/com-funcionen-els-antidepressius-el-paper-del-cbd-en-la-depressio\/"},"modified":"2025-03-24T12:18:27","modified_gmt":"2025-03-24T12:18:27","slug":"com-funcionen-els-antidepressius-el-paper-del-cbd-en-la-depressio","status":"publish","type":"page","link":"https:\/\/higeacbd.com\/ca\/com-funcionen-els-antidepressius-el-paper-del-cbd-en-la-depressio","title":{"rendered":"Com funcionen els antidepressius? El paper del CBD en la depressi\u00f3"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Anuncio superior&#8221; _builder_version=&#8221;4.9.4&#8243; z_index=&#8221;999&#8243; custom_margin=&#8221;0px||0px||true|false&#8221; custom_padding=&#8221;0px||0px||true|false&#8221; animation_direction=&#8221;top&#8221; custom_css_main_element=&#8221;position: relative;&#8221; global_module=&#8221;33910&#8243; global_colors_info=&#8221;{}&#8221; custom_css_main_element_last_edited=&#8221;on|desktop&#8221; custom_css_main_element_tablet=&#8221;position: relative;&#8221; custom_css_main_element_phone=&#8221;position: relative;&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#20a082&#8243; background_color_gradient_direction=&#8221;90deg&#8221; width=&#8221;100%&#8221; max_width=&#8221;100%&#8221; custom_margin=&#8221;0px||0px||true|false&#8221; custom_padding=&#8221;0px||0px||true|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_css_main_element=&#8221;display:flex;||align-items: center;||justify-content: center;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_blurb title=&#8221;Enviament gratu\u00eft a partir de 40\u20ac!&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#xe008;||divi||400&#8243; icon_color=&#8221;#FFFFFF&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;16px&#8221; _builder_version=&#8221;4.16&#8243; header_text_color=&#8221;#ffffff&#8221; header_font_size=&#8221;16px&#8221; header_line_height=&#8221;1.3em&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;230px&#8221; max_width_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;10px||||false|false&#8221; animation_direction=&#8221;left&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;14px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; icon_font_size=&#8221;16px&#8221; icon_font_size__hover_enabled=&#8221;off|desktop&#8221; global_colors_info=&#8221;{}&#8221; image_icon_width__hover_enabled=&#8221;off|desktop&#8221;][\/et_pb_blurb][et_pb_button button_url=&#8221;https:\/\/higeacbd.com\/tienda&#8221; button_text=&#8221;Comprar CBD&#8221; _builder_version=&#8221;4.16&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;15px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#0b5b44&#8243; button_bg_color_gradient_direction=&#8221;90deg&#8221; button_bg_color_gradient_stops=&#8221;#ff4ac2 0%|#ff4a9e 100%&#8221; button_bg_color_gradient_start=&#8221;#ff4ac2&#8243; button_bg_color_gradient_end=&#8221;#ff4a9e&#8221; button_border_width=&#8221;0px&#8221; button_border_radius=&#8221;20px&#8221; button_font=&#8221;|600|||||||&#8221; button_icon=&#8221;&#xe07a;||divi||400&#8243; custom_margin=&#8221;|||20px|false|false&#8221; custom_margin_tablet=&#8221;&#8221; custom_margin_phone=&#8221;|||10px|false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;2px|8px|2px|8px|true|true&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; button_text_size_tablet=&#8221;&#8221; button_text_size_phone=&#8221;13px&#8221; button_text_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Hero&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.65)&#8221; background_image=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/marihuana-cbd.jpg&#8221; background_blend=&#8221;soft-light&#8221; custom_padding=&#8221;3vw||1vw|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_cta title=&#8221;Com funcionen els antidepressius?  &#8221; _builder_version=&#8221;4.16&#8243; header_level=&#8221;h1&#8243; header_font=&#8221;|800|||||||&#8221; header_font_size=&#8221;45px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;|800|||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;20px&#8221; body_line_height=&#8221;1.6em&#8221; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#00a88d&#8221; button_border_width=&#8221;8px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;60px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;light&#8221; animation_direction=&#8221;bottom&#8221; header_font_size_tablet=&#8221;40px&#8221; header_font_size_phone=&#8221;30px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; button_text_color_hover=&#8221;#ffffff&#8221; button_border_radius_hover=&#8221;66px&#8221; button_letter_spacing_hover=&#8221;1px&#8221; button_bg_color_hover=&#8221;rgba(47,56,84,0.9)&#8221; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;on&#8221; button_text_color__hover=&#8221;#ffffff&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;on&#8221; button_border_radius__hover=&#8221;66px&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;on&#8221; button_letter_spacing__hover=&#8221;1px&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;on&#8221; button_bg_color__hover=&#8221;rgba(47,56,84,0.9)&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;]<\/p>\n<p>El paper del <strong>CBD en la depressi\u00f3 <\/strong> <\/p>\n<p>[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Products&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;20px||11px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;8px||17px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.20.2&#8243; text_font=&#8221;|500|||||||&#8221; text_text_color=&#8221;#000000&#8243; quote_font=&#8221;||||||||&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;80%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||12px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Tot i que les persones amb depressi\u00f3 han estat utilitzant antidepressius durant d\u00e8cades, la ci\u00e8ncia no havia descobert realment el seu funcionament biol\u00f2gic, fins ara. Un nou estudi posa en q\u00fcesti\u00f3 tot el que abans es coneixia <strong>sobre com funcionen els medicaments antidepressius.<\/strong><\/p>\n<p>Aquesta nova investigaci\u00f3 suggereix que els inhibidors selectius de recuperaci\u00f3 de serotonina(SSRIs),que s\u00f3n f\u00e0rmacs d&#8217;actuaci\u00f3 lenta en el tractament de la depressi\u00f3, i la ketaminad&#8217;actuaci\u00f3 r\u00e0pida es combinen directament amb un receptor de factors neurotr\u00f2fics derivat del cervell(BDNF). Com a resultat, promouen la plasticitat neuronal, que al seu torn alleuja la depressi\u00f3, per\u00f2 sense l&#8217;\u00fas de serotonina o glutamat.<\/p>\n<p>A continuaci\u00f3 es menteixen els resultats d&#8217;aquest nou estudi sobre el funcionament dels antidepressius. Tamb\u00e9 parlarem una mica sobre <strong>l&#8217;\u00fas del cannabidiol CBD i les seves propietats antidepressius.<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=&#8221;Productes&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_module=&#8221;16824&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_shop type=&#8221;best_selling&#8221; posts_number=&#8221;8&#8243; show_pagination=&#8221;on&#8221; module_class=&#8221;custom-shop&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|700|||||||&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_shop][et_pb_signup mailchimp_list=&#8221;higeacbd|5b4d14cf0e&#8221; first_name_field=&#8221;off&#8221; last_name_field=&#8221;off&#8221; title=&#8221;Subscriu-te i rep un 10% de descompte&#8221; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.16&#8243; header_level=&#8221;h4&#8243; header_font=&#8221;|800|||||||&#8221; header_text_align=&#8221;center&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;35px&#8221; header_line_height=&#8221;1.2em&#8221; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#00a88d&#8221; button_bg_color=&#8221;rgba(0,0,0,0)&#8221; button_border_width=&#8221;0px&#8221; button_border_radius=&#8221;0px&#8221; button_letter_spacing=&#8221;2px&#8221; button_font=&#8221;|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; button_custom_padding=&#8221;18px|0px|18px|0px|true|true&#8221; button_custom_padding_tablet=&#8221;14px||14px||true|true&#8221; button_custom_padding_phone=&#8221;12px||12px||true|true&#8221; button_custom_padding_last_edited=&#8221;on|phone&#8221; background_layout=&#8221;light&#8221; header_font_size_tablet=&#8221;25px&#8221; header_font_size_phone=&#8221;20px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; button_text_size_tablet=&#8221;14px&#8221; button_text_size_phone=&#8221;12px&#8221; button_text_size_last_edited=&#8221;on|phone&#8221; box_shadow_style_button=&#8221;preset4&#8243; box_shadow_horizontal_button=&#8221;0px&#8221; box_shadow_vertical_button=&#8221;2px&#8221; box_shadow_color_button=&#8221;#00a88d&#8221; global_colors_info=&#8221;{}&#8221; button_text_color__hover=&#8221;#28221d&#8221; button_text_color__hover_enabled=&#8221;on|hover&#8221; box_shadow_color_button__hover=&#8221;#000000&#8243; box_shadow_color_button__hover_enabled=&#8221;on|desktop&#8221;][\/et_pb_signup][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;0px|0px|0px|0px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;28px|40px|18px|40px||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; link_text_color=&#8221;#000000&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_text_color=&#8221;#ffffff&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; z_index=&#8221;2&#8243; background_layout=&#8221;dark&#8221; max_width=&#8221;70%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; hover_enabled=&#8221;0&#8243; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2>Com funcionen els antidepressius? Un nou estudi revela la veritat<\/h2>\n<p>La recerca de la qual parlem \u00e9s <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(21)00077-5\" target=\"_blank\" rel=\"noopener\">un estudi internacional<\/a> publicat a la revista <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(21)00077-5\">Cell,<\/a>liderat per dos neurocient\u00edfics <strong>de noms Eero Castr\u00e9n<\/strong> <strong>i Plino Cassaroto.<\/strong> Es va celebrar al Centre de Neuroci\u00e8ncies de la Universitat d&#8217;H\u00e8lsinki en col\u00b7laboraci\u00f3 amb el Departament de F\u00edsica.<\/p>\n<p>El prop\u00f2sit de la recerca era determinar <strong>com els antidepressius interactuen amb un receptor BDNF conegut com TrkB.<\/strong> En concret, es van estudiar els seg\u00fcents f\u00e0rmacs:<\/p>\n<ul>\n<li><strong>Fluoxetina<\/strong>\u2013 Un ISRS que es ven comercialment amb el nom <a href=\"https:\/\/higeacbd.com\/ca\/dades\/el-cbd-interactua-amb-la-fluoxetina-prozac\" title=\"CBD y prozac\">Prozac<\/a>.<\/li>\n<li><strong>Imipramine<\/strong>\u2013 Un antidepressiu tric\u00edclic.<\/li>\n<li>Ketamina\u2013 Un f\u00e0rmac dissociatiu d&#8217;acci\u00f3 r\u00e0pida utilitzat com una ter\u00e0pia revolucion\u00e0ria per a la depressi\u00f3.<\/li>\n<\/ul>\n<p>Inicialment es creia <strong>que els efectes de les SSREs i els efectes dels antidepressius tric\u00edclics,<\/strong>es van originar en la seva pr\u00f2pia capacitat per retenir m\u00e9s serotonina i norepinefrina en el cervell mitjan\u00e7ant l&#8217;augment dels seus nivells en la bretxa sin\u00e0ptica. Tamb\u00e9 es creia que l&#8217;efecte antidepressiu de la ketamina estava destinat a inhibir els receptors de glutamat.<\/p>\n<p>Aquests tres f\u00e0rmacs antidepressius <strong>analitzats en la recerca es<\/strong> van demostrar que interactuen amb el receptor <strong>TrkB.<\/strong> No obstant aix\u00f2, ho van fer sense augmentar o inhibir altres neurotransmissors com serotonina, norepinefrina, o glutamat.<\/p>\n<p>Cal assenyalar que altres investigacions ja havien identificat la relaci\u00f3 entre antidepressius que augmenten els factors neurotr\u00f2fics. Tal \u00e9s el cas de BDNF (Factor Neurotr\u00f2fic Derivat del Cervell), que <strong>juga un paper crucial en la regulaci\u00f3 de la neuroplasticitat.<\/strong><\/p>\n<p>No obstant aix\u00f2, els investigadors van pensar que els medicaments antidepressius van actuar indirectament en BDNF a trav\u00e9s de receptors de glutamat i serotonina. Els resultats d&#8217;aquesta recerca tenen el potencial de ser <strong>revolucionaris, revelant que els antidepressius realment s&#8217;uneixen directament als receptors de BDNF.<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;40px||40px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;||18px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/como-funcionan-los-antidepresivos.jpg&#8221; alt=&#8221;com funcionen els antidepressius&#8221; title_text=&#8221;com funcionen els antidepressius&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>BDNF i la seva relaci\u00f3 amb la plasticitat neuronal<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.19.4&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Durant dues d\u00e8cades, els cient\u00edfics han sabut que els f\u00e0rmacs antidepressius i l&#8217;exercici aer\u00f2bic promouen la plasticitat neuronal i el creixement de noves neurones. Tamb\u00e9 hi <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31903041\/\" target=\"_blank\" rel=\"noopener\">ha investigacions sobre l&#8217;exercici i el trastorn depressiu, on<\/a>s&#8217;ha investigat la correlaci\u00f3 entre l&#8217;augment de la BDNF indu\u00efda per l&#8217;exercici i un menor risc de<strong> trastorns depressius importants.<\/strong><\/p>\n<p>A m\u00e9s, altres investigacions s&#8217;han centrat a determinar com l&#8217;efic\u00e0cia dels antidepressius pot estar relacionada amb la BDNF. Els investigadors tamb\u00e9 han determinat com una via molecular relacionada amb la prote\u00efna activadora 1 facilita una reacci\u00f3 en cadena que activa m\u00faltiples gens, que al seu torn promouen la plasticitat neuronal.<\/p>\n<p>Aix\u00f2 permet al cervell revertir el dany neurol\u00f2gic que sol estar relacionat amb la depressi\u00f3. Una cosa interessant sobre aix\u00f2 \u00e9s que despr\u00e9s de dues o tres <strong>setmanes, els efectes regeneratius d&#8217;aquests canvis es poden veure i sentir.<\/strong> Els estudis en aquest sentit van ajudar a explicar per qu\u00e8 les SSREs triguen fins a 14 dies a activar-se.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;0px|0px|0px|0px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;46px|40px|41px|40px||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; link_text_color=&#8221;#000000&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_text_color=&#8221;#ffffff&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; z_index=&#8221;2&#8243; background_layout=&#8221;dark&#8221; max_width=&#8221;70%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>La ketamina t\u00e9 un efecte antidepressiu m\u00e9s r\u00e0pid<\/h2>\n<p>Investigacions anteriors van mostrar que en un tractament terap\u00e8utic amb f\u00e0rmacs inhibidors selectius de la recaptaci\u00f3 de serotonina (SSRS), els antidepressius arriben gradualment a una <strong>alta concentraci\u00f3 cerebral per unir-se al receptor TrkB.<\/strong> En canvi, la ketamina i l&#8217;esqueletamina, administrats per via intravenosa, arriben al nivell necessari per unir-se a Trkb en pocs minuts.<\/p>\n<p>Segons els investigadors, la difer\u00e8ncia en l&#8217;inici de l&#8217;acci\u00f3 de les SSRS i la ketamina pot ser el resultat de la seva diferent capacitat d&#8217;arribar al cervell, la concentraci\u00f3 necess\u00e0ria per unir-se al receptor TrkB. Tamb\u00e9 cal dir que la ketamina s&#8217;utilitza generalment com un anest\u00e8sic, per\u00f2 ara s&#8217;utilitza cada vegada m\u00e9s com un antidepressiu.<\/p>\n<p>Encara que els f\u00e0rmacs SSRS s&#8217;uneixen a la prote\u00efna transportant de serotonina molt m\u00e9s cobdiciosos que TrkB, la uni\u00f3 de la ketamina al receptor de glutamat i TrkB, es produeix en concentracions de f\u00e0rmacs similars.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;21px||18px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/colesterol-y-antidepresivos.jpg&#8221; alt=&#8221;colesterol i antidepressius&#8221; title_text=&#8221;colesterol i antidepressius&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.16&#8243; background_enable_image=&#8221;off&#8221; background_size=&#8221;contain&#8221; max_width_phone=&#8221;300px&#8221; max_width_last_edited=&#8221;off|tablet&#8221; custom_margin=&#8221;|||-30%|false|false&#8221; custom_margin_tablet=&#8221;|||-15%|false|false&#8221; custom_margin_phone=&#8221;|||-10%|false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>El colesterol podria jugar un paper clau en el treball dels antidepressius<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>La ubicaci\u00f3 precisa de la uni\u00f3 d&#8217;antidepressius a la regi\u00f3 transmembrana de TrkB va ser identificada a trav\u00e9s del modelatge molecular. Aquest model va ser realitzat per un grup d&#8217;investigadors del Departament de F\u00edsica de la Universitat d&#8217;H\u00e8lsinki, dirigit pel professor Ilpo Vattuainen. Per verificar el lloc, els cient\u00edfics van dur a terme estudis de la uni\u00f3 bioqu\u00edmica i mutacions introdu\u00efdes en el receptor TrkB.<\/p>\n<p>Un altre aspecte rellevant que ha demostrat el modelatge molecular \u00e9s que <strong>l&#8217;estructura del TrkB \u00e9s sensible a la concentraci\u00f3 de colesterol en la membrana cel\u00b7lular.<\/strong> Aix\u00f2 \u00e9s important a mesura que TrkB es mou en compartiments de membrana, que se sap que s\u00f3n una rica font de colesterol, com ara membranes sin\u00e0ptiques. La uni\u00f3 de TrkB amb el f\u00e0rmac antidepressiu estabilitza els dimers, que s\u00f3n estructures compostes per dos receptors TrkB.<\/p>\n<p>Quan aix\u00f2 succeeix, s&#8217;inhibeix el despla\u00e7ament dels receptors de TrkB, alhora que augmenta la seva quantitat en membranes cel\u00b7lulars sin\u00e0ptiques. Com a resultat, els efectes de BDNF es milloren. En altres paraules, els <strong>medicaments antidepressius en realitat no activen directament TrkB.<\/strong> El que realment fan \u00e9s sensibilitzar el destinatari als efectes de BDNF.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;0px|0px|0px|0px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;46px|40px|41px|40px||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; link_text_color=&#8221;#000000&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_text_color=&#8221;#ffffff&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; z_index=&#8221;2&#8243; background_layout=&#8221;dark&#8221; max_width=&#8221;70%&#8221; max_width_tablet=&#8221;90%&#8221; max_width_phone=&#8221;100%&#8221; max_width_last_edited=&#8221;on|tablet&#8221; module_alignment=&#8221;center&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Es necessita m\u00e9s recerca sobre colesterol i antidepressius<\/h2>\n<p>Tot aix\u00f2 \u00e9s important, ja que hi ha evid\u00e8ncies <strong>que les persones amb tend\u00e8ncies su\u00efcides o que s&#8217;han su\u00efcidat tenen nivells baixos de colesterol.<\/strong> El problema amb aix\u00f2 \u00e9s que establir una relaci\u00f3 directa amb aix\u00f2 \u00e9s complicat. Especialment des que el cervell utilitza principalment el colesterol que produeix.<\/p>\n<p>A m\u00e9s, podria haver-hi un conflicte amb les estad\u00edstiques, que s\u00f3n medicaments consumits per milions de persones a tot el m\u00f3n. Aquests medicaments s&#8217;utilitzen per controlar els nivells de colesterol a la sang. De fet, <strong>els investigadors es van preguntar si les estad\u00edstiques estaven bloquejant l&#8217;efecte antidepressiu.<\/strong><\/p>\n<p>La investigaci\u00f3 tamb\u00e9 va servir per demostrar que quan s&#8217;injecta una alta dosi d&#8217;estatines, amb l&#8217;objectiu de reduir els nivells de colesterol en el cervell, els antidepressius ja no augmenten la neuroplasticitat. A continuaci\u00f3, els investigadors van analitzar estudis humans en qu\u00e8 aix\u00f2 no passa perqu\u00e8 les estad\u00edstiques no arriben al cervell.<\/p>\n<p>\u00c9s a dir, amb dosis d&#8217;estatina comunament utilitzades en els \u00e9ssers humans, aquests f\u00e0rmacs no generen cap problema. Pel que fa als nivells de colesterol en sang, els cient\u00edfics coincideixen que es necessita m\u00e9s investigaci\u00f3 per permetre&#8217;ls trobar algun tipus de vincle.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;36px|0px|0px|0px||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/cbd-antidepresivo.jpg&#8221; alt=&#8221;antidepressiu de CBD&#8221; title_text=&#8221;antidepressiu de CBD&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;5%&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;||||||||&#8221; text_font_size=&#8221;16px&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Per qu\u00e8 els antidepressius funcionen m\u00e9s r\u00e0pid que els altres?<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Ara que els investigadors ja saben que la plasticitat cerebral \u00e9s fonamental en l&#8217;acci\u00f3 dels antidepressius, la pregunta que sorgeix \u00e9s per qu\u00e8 els antidepressius treballen m\u00e9s r\u00e0pid que altres? Els cient\u00edfics <strong>saben que molts f\u00e0rmacs antidepressius convencionals,<\/strong>com l&#8217;Escitalopram, o fluoxetina, requereixen setmanes per comen\u00e7ar a tenir efecte a nivell psicol\u00f2gicament visible.<\/p>\n<p>Per contra, hi ha altres medicaments antidepressius que actuen molt m\u00e9s r\u00e0pid, com l&#8217;esmentada ketamina. Tot sembla indicar que \u00e9s una q\u00fcesti\u00f3 relacionada amb el temps que es triga a arribar a aquests f\u00e0rmacs en <strong>les concentracions necess\u00e0ries en el cervell.<\/strong> \u00c9s per aix\u00f2 que els porta diversos dies, i tamb\u00e9 per qu\u00e8 no poden deixar de consumir.<\/p>\n<p>En el cas dels f\u00e0rmacs d&#8217;acci\u00f3 r\u00e0pida, possiblement poden penetrar la barrera del cervell sanguini amb m\u00e9s facilitat, fins que finalment obtinguin la concentraci\u00f3 necess\u00e0ria per activar el receptor TrkB.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/investigacion-antidepresivos.jpg&#8221; alt=&#8221;recerca antidepressiva&#8221; title_text=&#8221;recerca antidepressiva&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;5%&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;||||||||&#8221; text_font_size=&#8221;16px&#8221; header_2_font=&#8221;|800|||||||&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Punts clau de recerca<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Diversos medicaments antidepressius, com ara les SSROs i la ketamina, estan directament vinculats al receptor TrkB.<\/li>\n<li>Aquesta uni\u00f3 entre els f\u00e0rmacs antidepressius i el receptor TrkB facilita l&#8217;acci\u00f3 de la BDNF, la plasticitat neuronal promotora.<\/li>\n<li>A m\u00e9s d&#8217;aix\u00f2, la investigaci\u00f3 revela que la mutaci\u00f3 puntual a l&#8217;\u00e0rea transmembrana del receptor TrkB bloqueja els efectes dels medicaments antidepressius.<\/li>\n<li>Els baixos nivells de colesterol poden estar relacionats amb l&#8217;efecte dels antidepressius. (Es necessita m\u00e9s recerca sobre aquest tema per ara)<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;21px||18px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/antidepresivos-cbd-corto-plazo.jpg&#8221; alt=&#8221;antidepressius cbd a curt termini&#8221; title_text=&#8221;antidepressius cbd a curt termini&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.16&#8243; background_enable_image=&#8221;off&#8221; background_size=&#8221;contain&#8221; max_width_phone=&#8221;300px&#8221; max_width_last_edited=&#8221;off|tablet&#8221; custom_margin=&#8221;|||-30%|false|false&#8221; custom_margin_tablet=&#8221;|||-15%|false|false&#8221; custom_margin_phone=&#8221;|||-10%|false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Efectes antidepressius del CBD a curt termini<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Els resultats van revelar que CANNabidiol CBD va induir un efecte antidepressiu en ratolins d&#8217;una manera dependent de la dosi. Aquesta mateixa prova tamb\u00e9 es va realitzar en rates, i els resultats obtinguts van ser similars als dels ratolins. Els <strong>investigadors tamb\u00e9 van trobar que tots aquests efectes antidepressius aguts, avaluats<\/strong>despr\u00e9s de la prova de nataci\u00f3 30 minuts despr\u00e9s del tractament, estaven relacionats amb la <strong>capacitat de cannabidiol per augmentar els nivells de BDNF.<\/strong><\/p>\n<p>Aquest augment dels nivells de BDNF es va presentar tant en l&#8217;hipocamp com en l&#8217;escor\u00e7a prefrontal dels rosegadors. Aix\u00f2 \u00e9s important ja que el factor neurotr\u00f2fic derivat del cervell (BDNF) \u00e9s un factor crucial per al creixement de les neurones. No nom\u00e9s aix\u00f2, els investigadors tamb\u00e9 van trobar<strong> que els marcadors de plasticitat sin\u00e0ptica, indispensables per a la remodelaci\u00f3<\/strong>cerebral, tamb\u00e9 van experimentar un augment en l&#8217;escor\u00e7a prefrontal del cervell.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Feature&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#f3f3f1&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;21px||18px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;|auto|-2px|auto||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/cbd-antidepresivos-largo-plazo.jpg&#8221; alt=&#8221;antidepressius a llarg termini cbd&#8221; title_text=&#8221;antidepressius a llarg termini cbd&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.16&#8243; background_enable_image=&#8221;off&#8221; background_size=&#8221;contain&#8221; max_width_phone=&#8221;300px&#8221; max_width_last_edited=&#8221;off|tablet&#8221; custom_margin=&#8221;|||-30%|false|false&#8221; custom_margin_tablet=&#8221;|||-15%|false|false&#8221; custom_margin_phone=&#8221;|||-10%|false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding_tablet=&#8221;|20%|||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|800|||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||||false|false&#8221; custom_margin_tablet=&#8221;|||0%|false|false&#8221; custom_margin_last_edited=&#8221;off|desktop&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Efectes antidepressius a llarg termini del CBD<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font_size_tablet=&#8221;14px&#8221; text_font_size_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Pel que fa als efectes antidepressius del CBD cannabidiol a llarg termini, els cient\u00edfics van trobar que estaven associats amb <strong>una millora en la funci\u00f3 sin\u00e0ptica en l&#8217;escor\u00e7a prefrontal.<\/strong> Aquesta va ser la prova de nataci\u00f3 en ratolins avaluada 7 dies despr\u00e9s que se&#8217;ls va donar la dosi de CDB.<\/p>\n<p>Els resultats donen suport a la teoria que el cannabidiol CBD extret del c\u00e0nnabis \u00e9s en realitat un antidepressiu d&#8217;acci\u00f3 r\u00e0pida. No nom\u00e9s aix\u00f2, sin\u00f3 que els seus efectes antidepressius tamb\u00e9 es sostenen. En altres paraules, el consum de CBD en dosis adequades podria conduir a una activitat anti depressiva a llarg termini.<\/p>\n<p>Si b\u00e9 \u00e9s obvi que es necessita m\u00e9s investigaci\u00f3 sobre el tema, els resultats d&#8217;aquests estudis suggereixen que el CDB podria ser un tractament terap\u00e8utic prometedor per combatre els trastorns de l&#8217;estat d&#8217;\u00e0nim, i m\u00e9s concretament la depressi\u00f3.<\/p>\n<p>No hem d&#8217;oblidar que el CBD ja \u00e9s ben conegut pels seus beneficis per a la salut en altres condicions com la malaltia d&#8217;Alzheimer, el dolor cr\u00f2nic o la disfunci\u00f3 neurol\u00f2gica. Per tant, no seria estrany si tamb\u00e9 va tenir un efecte positiu en el tractament de la depressi\u00f3.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#f3f3f1&#8243; custom_padding=&#8221;0px|0px|0px|0px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; make_equal=&#8221;on&#8221; admin_label=&#8221;Cta Fila&#8221; module_class=&#8221; et_pb_row_fullwidth&#8221; _builder_version=&#8221;4.16&#8243; width=&#8221;100%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;&#8221; width_last_edited=&#8221;on|desktop&#8221; max_width=&#8221;100%&#8221; max_width_tablet=&#8221;100%&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px|0px|0px|0px&#8221; make_fullwidth=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2021\/03\/cbd-depresion.jpg&#8221; alt=&#8221;depresi\u00f3 de cbd&#8221; title_text=&#8221;depresi\u00f3 de cbd&#8221; force_fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00a88d&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_cta title=&#8221;El paper del CBD en la depressi\u00f3&#8221; button_url=&#8221;#top&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;|800|||||||&#8221; header_text_color=&#8221;#ffffff&#8221; body_font=&#8221;Montserrat|500|||||||&#8221; body_text_color=&#8221;#ffffff&#8221; body_link_text_color=&#8221;#000000&#8243; use_background_color=&#8221;off&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#2f3854&#8243; button_border_width=&#8221;10px&#8221; button_border_color=&#8221;rgba(47,56,84,0)&#8221; button_border_radius=&#8221;60px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Montserrat|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; button_alignment=&#8221;left&#8221; text_orientation=&#8221;left&#8221; max_width=&#8221;580px&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|desktop&#8221; module_alignment=&#8221;left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;40px|60px|2px|60px||&#8221; button_text_color_hover=&#8221;#2f3854&#8243; button_border_radius_hover=&#8221;66px&#8221; button_letter_spacing_hover=&#8221;1px&#8221; button_bg_color_hover=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;on&#8221; button_text_color__hover=&#8221;#2f3854&#8243; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;on&#8221; button_border_radius__hover=&#8221;66px&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;on&#8221; button_letter_spacing__hover=&#8221;1px&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;on&#8221; button_bg_color__hover=&#8221;#ffffff&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;]Com es va esmentar anteriorment, les opcions de tractament actuals per a la depressi\u00f3, que inclou l&#8217;\u00fas de f\u00e0rmacs antidepressius, poden ser problem\u00e0tiques. Aix\u00f2 \u00e9s principalment perqu\u00e8 els pacients sovint han de fer front a un retard associat amb els seus efectes. En aquest <strong>sentit, el CBD pot tenir el potencial de ser una alternativa eficient en la lluita contra la depressi\u00f3.<\/strong><\/p>\n<p>Les investigacions de 2019 van <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29869197\/\" target=\"_blank\" rel=\"noopener\">revelar que el cannabidiol (CBD) indueix efectes similars als antidepressius d&#8217;acci\u00f3 r\u00e0pida i sostinguts.<\/a> Tot aix\u00f2 mitjan\u00e7ant l&#8217;augment de la senyalitzaci\u00f3 i la sinptogenosi de BDNF en l&#8217;escor\u00e7a prefrontal del cervell. Investigadors de la Universitat de Sao Paulo al Brasil van <strong>analitzar els efectes antidepressius del CBD<\/strong> sobre rates i ratolins per determinar si aquest cannabidiol t\u00e9 un r\u00e0pid inici d&#8217;acci\u00f3.<\/p>\n<p>Durant la investigaci\u00f3 de CDB es va administrar com una sola dosi en una quantitat que podria ser 7, 10, o 30 mg per quilo de pes corporal. A continuaci\u00f3, els cient\u00edfics van sotmetre els rosegadors a una prova de nataci\u00f3 for\u00e7ada, despr\u00e9s de 30 minuts o fins a 7 dies despr\u00e9s de comen\u00e7ar el tractament.[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Subscribe&#8221; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_stops=&#8221;#f3f3f1 0%|rgba(255,255,255,0) 30%&#8221; background_color_gradient_overlays_image=&#8221;on&#8221; background_color_gradient_start=&#8221;#f3f3f1&#8243; background_color_gradient_end=&#8221;rgba(255,255,255,0)&#8221; background_color_gradient_end_position=&#8221;30%&#8221; background_image=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/aceite-de-cannabis-cbd.jpg&#8221; custom_padding=&#8221;100px|0px|30vw|0px&#8221; animation_direction=&#8221;bottom&#8221; saved_tabs=&#8221;all&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; 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font_icon=&#8221;&#x56;||divi||400&#8243; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#ffffff&#8221; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; body_font=&#8221;|700||on|||||&#8221; body_text_color=&#8221;#FFFFFF&#8221; body_font_size=&#8221;16px&#8221; body_letter_spacing=&#8221;2px&#8221; body_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;14px&#8221; body_font_size_phone=&#8221;12px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"https:\/\/higeacbd.com\/it\/tienda\/olis\/olio-cbd-10\" title=\"Aceite CBD 10%\">CDB al 10%<\/a>[\/et_pb_blurb][et_pb_blurb use_icon=&#8221;on&#8221; 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title_text=&#8221;botiga d&#039;esp\u00e8cies-07&#8243; _builder_version=&#8221;4.16&#8243; custom_margin_tablet=&#8221;0px||||false|false&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_blurb title=&#8221;Bloc&#8221; url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6Ijc3NyJ9fQ==@&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#ffffff&#8221; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; _dynamic_attributes=&#8221;url&#8221; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#ffffff&#8221; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; 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url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE5OTkifX0=@&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#ffffff&#8221; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; _dynamic_attributes=&#8221;url&#8221; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#ffffff&#8221; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][et_pb_blurb title=&#8221;Terpens&#8221; url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI3NDEifX0=@&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#ffffff&#8221; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; _dynamic_attributes=&#8221;url&#8221; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#ffffff&#8221; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][et_pb_blurb title=&#8221;Extracci\u00f3 de CBD&#8221; url=&#8221;https:\/\/higeacbd.com\/ca\/olis\/metodes-dextraccio-de-cbd&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#ffffff&#8221; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#ffffff&#8221; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][et_pb_blurb title=&#8221;Olis portadors&#8221; url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIzNzcifX0=@&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#ffffff&#8221; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; _dynamic_attributes=&#8221;url&#8221; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#ffffff&#8221; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; 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text_font_size_phone=&#8221;16px&#8221; text_font_size_last_edited=&#8221;on|desktop&#8221; header_3_font_size_tablet=&#8221;14px&#8221; header_3_font_size_phone=&#8221;12px&#8221; header_3_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Av\u00eds legal i pol\u00edtica de privacitat<\/h4>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/higeacbd.com\/wp-content\/uploads\/2020\/07\/spice-shop-32-1-1.png&#8221; alt=&#8221;Simbolo higea (A prop de Simbolo higea)&#8221; title_text=&#8221;Simbolo higea (A prop de Simbolo higea)&#8221; _builder_version=&#8221;4.16&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_blurb url_new_window=&#8221;on&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#000000&#8243; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; body_font=&#8221;|700||on|||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_letter_spacing=&#8221;2px&#8221; body_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; link_option_url_new_window=&#8221;on&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; body_font_size_tablet=&#8221;14px&#8221; body_font_size_phone=&#8221;12px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/higeacbd.com\/ca\/avis-legal-i-condicions-generals\" target=\"_blank\" rel=\"noopener nofollow\">AV\u00cdS LEGAL<\/a><\/p>\n<p>[\/et_pb_blurb][et_pb_blurb url_new_window=&#8221;on&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x56;||divi||400&#8243; icon_color=&#8221;#000000&#8243; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;|700||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;16px&#8221; header_letter_spacing=&#8221;2px&#8221; header_line_height=&#8221;1.8em&#8221; body_font=&#8221;|700||on|||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_letter_spacing=&#8221;2px&#8221; body_line_height=&#8221;1.8em&#8221; custom_margin=&#8221;||0px||false|false&#8221; animation=&#8221;off&#8221; link_option_url_new_window=&#8221;on&#8221; header_font_size_tablet=&#8221;14px&#8221; header_font_size_phone=&#8221;12px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; body_font_size_tablet=&#8221;14px&#8221; body_font_size_phone=&#8221;12px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"https:\/\/higeacbd.com\/ca\/politica-de-privacitat-i-avis-sobre-les-cookies\" target=\"_blank\" rel=\"noopener nofollow\">PRIVACITAT I COOKIES<\/a>[\/et_pb_blurb][et_pb_blurb url_new_window=&#8221;on&#8221; 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